Is Nystatin/Triamcinolone in Shortage in 2026?

If you've been told by your pharmacy that Nystatin/Triamcinolone is unavailable, you're probably wondering: is there an actual shortage? The answer is nuanced.

As of early 2026, Nystatin/Triamcinolone is not listed as a formal nationwide shortage by the FDA. However, intermittent supply disruptions from individual generic manufacturers have created regional and local stock-outs that affect patients across the country. In other words, your pharmacy might not have it — but that doesn't mean no one does.

In this post, we'll break down what's happening with Nystatin/Triamcinolone availability, what it costs right now, and exactly what you can do to get your prescription filled.

What Is Nystatin/Triamcinolone?

Nystatin/Triamcinolone is a prescription topical cream or ointment used to treat fungal skin infections caused by Candida yeast. It combines:

• Nystatin — kills the yeast causing the infection
• Triamcinolone Acetonide — reduces redness, itching, and swelling

It's typically applied twice a day for about two weeks. It was previously sold under the brand name Mycolog-II, but today only generic versions are available from manufacturers like Taro Pharmaceuticals, Perrigo, and Glenmark.

For a complete overview, see What Is Nystatin/Triamcinolone?

Why Is Nystatin/Triamcinolone Hard to Find?

Several factors contribute to periodic availability issues:

Limited Manufacturers

Only a handful of generic companies produce Nystatin/Triamcinolone cream and ointment. When one manufacturer experiences a production delay — whether due to equipment maintenance, quality control issues, or raw material shortages — the remaining manufacturers may not be able to fully meet demand.

Distributor Inventory Gaps

Large pharmacy chains typically order from centralized distributors. If a distributor's warehouse runs low, every pharmacy it supplies may show the product as unavailable simultaneously. Independent pharmacies often use different distribution networks and may still have stock.

Seasonal Demand Fluctuations

Fungal skin infections are more common during warm, humid months. The resulting spike in prescriptions can temporarily strain the supply of Nystatin/Triamcinolone, especially in southern and coastal regions.

For a deeper dive into these factors, read our post on why Nystatin/Triamcinolone is hard to find.

How Much Does Nystatin/Triamcinolone Cost in 2026?

Since it's available only as a generic, Nystatin/Triamcinolone is generally affordable:

• 30g tube: $15–$45 cash price (without insurance)
• 60g tube: $25–$80 cash price
• With a discount card: As low as $10–$25 for a 30g tube through GoodRx, SingleCare, or RxSaver
• With insurance: Typically a Tier 1 or Tier 2 copay ($0–$15 at most plans)

Prices can vary significantly between pharmacies, so it's worth comparing. For detailed savings strategies, see our guide on how to save money on Nystatin/Triamcinolone.

Are There New Options or Alternatives?

While no new formulations of Nystatin/Triamcinolone have been introduced recently, patients who can't find it have several alternatives:

• Clotrimazole/Betamethasone (Lotrisone) — A similar antifungal/steroid combination with a broader-spectrum antifungal
• Nystatin cream alone — Treats the infection without the steroid
• Ketoconazole cream — A prescription antifungal without a steroid component
• Miconazole cream (OTC) — An over-the-counter antifungal available without a prescription

Your doctor can help you decide which alternative is best for your situation. Read our full comparison in Alternatives to Nystatin/Triamcinolone.

How to Find Nystatin/Triamcinolone in Stock Right Now

If your pharmacy doesn't have Nystatin/Triamcinolone, here's what to do:

1. Search on Medfinder — Check real-time pharmacy availability in your area
2. Try independent pharmacies — They often use different distributors and may have stock when chains don't
3. Ask for a special order — Your pharmacist may be able to get it in 1–2 business days
4. Consider mail order — Mail-order pharmacies often have larger inventories
5. Talk to your doctor — They can prescribe an alternative if needed

For step-by-step guidance, see our post on how to find Nystatin/Triamcinolone in stock near you.

Final Thoughts

While Nystatin/Triamcinolone isn't in a formal nationwide shortage in 2026, real-world availability can be spotty depending on where you live and which pharmacy you use. The best strategy is to be proactive: use tools like Medfinder to check stock before driving to the pharmacy, and don't hesitate to explore independent pharmacies or ask about alternatives.

Your fungal skin infection won't wait, and neither should your treatment. With the right tools and a little flexibility, you can get the medication you need.