Konvomep Availability: What Providers and Prescribers Need to Know in 2026

Konvomep (omeprazole and sodium bicarbonate for oral suspension) offers a clinically important liquid PPI option, particularly for patients with dysphagia, those requiring tube feeding, or those transitioning from IV acid suppression. However, prescribers are increasingly encountering patient callbacks because local pharmacies don't stock it. This guide is designed to help you understand the real-world availability landscape and take proactive steps for your patients.

Clinical Overview of Konvomep

Konvomep was FDA-approved in August 2022 and became commercially available in Q1 2023. It provides omeprazole 2 mg/mL with sodium bicarbonate 84 mg/mL after reconstitution, in a strawberry-flavored oral suspension. It is the only FDA-approved kit-style oral suspension of omeprazole/sodium bicarbonate currently on the market.

FDA-approved indications in adults:

Short-term treatment (4–8 weeks) of active benign gastric ulcer (40 mg once daily)

Reduction of risk of upper GI bleeding in critically ill adult patients (40 mg loading dose, 40 mg at 6–8 hours, then 40 mg daily for 14 days)

Key pharmacokinetic note: Sodium bicarbonate raises gastric pH transiently, enabling rapid absorption of immediate-release omeprazole before acid degradation. The mean plasma half-life after oral dosing is approximately 1 hour, with CYP2C19 and CYP3A4 mediating metabolism.

Why Patients Call Back After Being Prescribed Konvomep

The most common reason patients contact your office after a Konvomep prescription is pharmacy unavailability. Here's the structural reason:

Refrigeration requirement. Konvomep must be stored at 2–8°C; reconstituted suspension expires 30 days post-preparation. Most retail pharmacies allocate cold storage space for high-volume products.

Pharmacist reconstitution. The product is a 2-bottle kit that requires preparation before dispensing. Pharmacies with lower volume may not keep prepared suspension on hand.

Single-source brand product. No generic is available. Formulary pressure and tier placement may reduce pharmacy motivation to stock Konvomep proactively.

Clinical Situations Where Konvomep Is Most Appropriate

Patients with dysphagia who need PPI therapy and cannot take capsules or ODTs

Patients on continuous or intermittent NG/OG tube feeding who require oral acid suppression

Post-ICU patients with active stress ulcer prophylaxis needs transitioning to outpatient care

Patients with active benign gastric ulcers who need liquid formulation

Note: Konvomep is not approved for pediatric patients. For tube-fed patients, suspend enteral feeding 3 hours before and 1 hour after administration.

How to Help Your Patients Access Konvomep

When prescribing Konvomep, consider proactively directing patients to the most likely sources:

Send to your hospital outpatient pharmacy. Hospital-affiliated pharmacies are the highest-probability source for Konvomep given their familiarity with specialty liquid medications.

Call a specialty pharmacy in advance. If your practice works with a specialty pharmacy partner, a quick call before prescribing can confirm availability and smooth the fill process.

Provide the manufacturer's savings program information. Eligible commercially insured patients may pay as little as $5 via Azurity's paperless co-pay program. This can be found at AzuritySolutions.com.

Recommend medfinder for pharmacy searching. medfinder.com/providers offers a resource to help your patients find which pharmacies near them have Konvomep in stock, reducing back-and-forth calls to your office.

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Key Drug Interactions and Contraindications to Document

Rilpivirine (contraindicated): PPIs including Konvomep significantly decrease rilpivirine levels; risk of virologic failure

Clopidogrel (avoid): Omeprazole inhibits CYP2C19 conversion of clopidogrel to active metabolite, reducing antiplatelet effect

Sodium content warning: Each 40 mg dose contains 526 mg sodium (22.8 mEq). Caution in CHF, CKD, hypertension, and patients on sodium-restricted diets. Avoid in Bartter's syndrome, hypokalemia, and hypocalcemia.

St. John's Wort and rifampin: Avoid concomitant use — CYP3A4 inducers significantly reduce omeprazole exposure

Appropriate Clinical Alternatives When Konvomep Is Unavailable

Zegerid (omeprazole/sodium bicarbonate) powder packets: Same active ingredients, can be mixed with water; also compatible with NG/OG tube administration

Esomeprazole sprinkle capsules: Granules can be mixed with applesauce or water, compatible with NG tube; available as generic

Lansoprazole ODT or suspension packets: Orally disintegrating tablets useful for dysphagia; suspension packets for tube feeding

Compounded omeprazole/sodium bicarbonate suspension: A compounding pharmacist can prepare an equivalent formulation when Konvomep is unavailable

Skip the calls, skip the stress.

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How medfinder Supports Your Patients

medfinder is a paid patient service that calls local pharmacies to confirm which ones have a specific medication in stock. If your patients are calling back because they can't fill their Konvomep prescription, referring them to medfinder.com/providers can reduce those callbacks and help your patients get their medication faster.