Your Pharmacy Is Out of Endometrin — Now What?

You've got your prescription for Endometrin, your embryo transfer is coming up, and the pharmacy just told you they're out of stock. It's one of the most frustrating situations in fertility treatment — and unfortunately, it's not uncommon.

Endometrin (Progesterone vaginal insert, 100 mg) is a critical medication for luteal phase support during IVF and other assisted reproductive technology (ART) cycles. Because it's a specialty medication that isn't stocked everywhere, finding it can take some extra effort. But with the right approach, you can locate it faster than you might think.

Here are three proven strategies to help you find Endometrin in stock near you.

Tip #1: Use Medfinder to Search Real-Time Availability

Instead of calling pharmacy after pharmacy, use Medfinder to check which pharmacies near you have Endometrin in stock right now. Medfinder is specifically designed to help patients find hard-to-locate medications, and it can save you hours of phone calls during an already stressful time.

Simply search for Endometrin, enter your location, and see which pharmacies have it available. It's free to use and updated regularly.

This is especially helpful because Endometrin distribution is concentrated in specialty pharmacies — places you might not think to call on your own. Medfinder includes these in its results so you get the full picture.

Tip #2: Try Independent and Specialty Pharmacies

When the big chain pharmacies are out of stock, independent pharmacies and fertility specialty pharmacies are often your best bet. Here's why:

• Specialty fertility pharmacies like Freedom Fertility, Encompass Fertility, Village Fertility Pharmacy, and Alto Pharmacy have direct relationships with Ferring Pharmaceuticals and fertility drug distributors. They're more likely to have Endometrin in stock or be able to get it quickly.
• Independent pharmacies sometimes have access to different distributors than the major chains. A local independent pharmacy may have stock when CVS or Walgreens doesn't.
• Your fertility clinic's in-house pharmacy (if they have one) may dispense Endometrin directly. Ask your clinic about this option.

Don't be afraid to cast a wider net. A pharmacy 30 minutes away that has Endometrin in stock is better than one next door that doesn't.

Tip #3: Time Your Prescription Strategically

Timing matters when it comes to filling specialty prescriptions:

• Get your prescription sent early. If you know you'll need Endometrin for an upcoming cycle, ask your clinic to submit the prescription as soon as possible — ideally a week or more before you need it. This gives the pharmacy time to order it if they don't have it on hand.
• Call in the morning. Pharmacies receive deliveries early in the day. If you call first thing in the morning, you're more likely to catch them right after restocking.
• Ask about the generic. Since Xiromed launched the first generic Progesterone vaginal insert in late 2025, pharmacies may carry the generic even if they don't have brand-name Endometrin. The generic contains the same 100 mg of Progesterone in the same vaginal insert format.

What If You Still Can't Find Endometrin?

If you've tried everything and Endometrin is still nowhere to be found, here's what to do next:

Talk to Your Doctor About Alternatives

Your reproductive endocrinologist can prescribe an alternative form of Progesterone. Options include:

• Crinone — a Progesterone vaginal gel (8%) applied once or twice daily
• Prometrium — an oral Progesterone capsule that some clinics prescribe for vaginal use off-label
• Progesterone in Oil (PIO) — an intramuscular injection that's been used for decades as the traditional approach to luteal phase support

Each alternative has different pros and cons. For a detailed comparison, see our guide to Endometrin alternatives.

Ask Your Clinic to Help

Fertility clinics deal with medication availability issues regularly. Your nurse coordinator or pharmacy liaison may be able to locate Endometrin through their network, arrange a transfer from another pharmacy, or quickly switch your protocol to an available alternative. Don't hesitate to reach out to your care team.

Check Back Frequently

Pharmacy stock changes daily. If a pharmacy tells you they're out today, ask when they expect their next shipment. Set a reminder to call back. Or better yet, set up an alert on Medfinder to stay updated.

Final Thoughts

Finding Endometrin in 2026 is easier than it was during the peak of the 2023-2024 shortage, thanks in part to the arrival of a generic version. But it can still require some effort, especially if you're relying on retail chain pharmacies.

The key takeaways: use Medfinder to search availability, explore specialty and independent pharmacies, and plan ahead whenever possible. If you want to understand why Endometrin is hard to find, we've got a full explainer on that too.

You've got enough to worry about during fertility treatment. Let's take the pharmacy hunt off your plate.