Endometrin Is Expensive — But You Have Options

If you've seen the cash price for Endometrin, you probably did a double take. At $327 to $393 for a box of 21 inserts, Endometrin isn't cheap — and since most patients need it for up to 10 weeks at two to three doses per day, the total cost can add up fast.

Fertility treatment is already one of the most expensive medical journeys a person can go through. The last thing you need is to overpay for a medication when there are ways to bring the cost down. In this guide, we'll walk through every major option for saving money on Endometrin in 2026.

What Does Endometrin Cost Without Insurance?

Let's start with the baseline numbers so you know what you're working with:

• Brand-name Endometrin: Approximately $327-$393 per box of 21 inserts (100 mg each) at retail cash price.
• A typical 10-week course at 3x daily: You'd need roughly 210 inserts, or about 10 boxes. At retail price, that's $3,270 to $3,930 for the full course.
• A typical 10-week course at 2x daily: Roughly 140 inserts, or about 7 boxes. That's $2,289 to $2,751 at retail.

These numbers are why finding savings matters. Even modest per-box discounts make a meaningful difference over a full treatment course.

Coupon and Discount Cards

Prescription coupon cards are one of the easiest ways to reduce your Endometrin cost immediately. Here are the most useful options:

GoodRx

GoodRx shows prices as low as $91 for 21 inserts at participating pharmacies. That's a savings of over 70% compared to retail price. Simply search for Endometrin on goodrx.com, select your pharmacy, and show the coupon at pickup. No insurance required.

SingleCare

SingleCare offers Endometrin coupons bringing the price down to approximately $112 for 21 inserts. Available at most major pharmacies including CVS, Walgreens, and Walmart.

Other Coupon Services

Additional coupon options to check include:

• RxSaver — compare prices at pharmacies near you
• Optum Perks — digital coupons accepted at most chains
• BuzzRx — free savings card with pharmacy price comparison
• America's Pharmacy — discount card accepted at many locations

Pro tip: Prices vary by pharmacy, so always compare across multiple locations using your coupon card. A specialty pharmacy might have a different price than a retail chain for the same coupon.

Consider the Generic

Since Xiromed launched the first generic Progesterone vaginal insert in September 2025, you may be able to get the generic version at an even lower price than brand-name Endometrin with a coupon. Ask your pharmacist about the generic and check coupon prices for "Progesterone vaginal insert" specifically.

Ferring Manufacturer Savings Programs

Ferring Pharmaceuticals, the maker of Endometrin, offers several programs to help patients afford their medication:

h.e.a.r.t.+ Savings Card

The Ferring h.e.a.r.t.+ Savings Card provides up to $30 in savings every 2 weeks on Endometrin. It's available for both insured and cash-paying patients.

How to get it:

• Visit ferringfertility.com or ask your fertility clinic
• Enroll and receive your savings card
• Present the card at the pharmacy with your Endometrin prescription

While $30 every two weeks may not sound like a huge amount, over a 10-week treatment course, that's up to $150 in total savings.

OneHeart Program

Ferring's OneHeart program offers additional support for eligible patients. Contact OneHeart@envisionrx.com or call during business hours (Monday-Friday, 9am-5pm EST) for information about eligibility and enrollment.

HeartTomorrow Program

The Ferring HeartTomorrow program provides discounted pricing on select Ferring fertility products for eligible cash-paying patients undergoing fertility preservation (such as egg freezing). If you're in this category, ask your clinic about enrollment.

Patient Assistance Programs

If you're experiencing financial hardship, additional assistance may be available:

Ferring Patient Assistance

Ferring offers patient assistance programs for qualifying patients who cannot afford their medications. Visit ferringusa.com for details and eligibility requirements.

Nonprofit Assistance Programs

Several nonprofit organizations help patients access affordable medications:

• NeedyMeds (needymeds.org) — searchable database of patient assistance programs, coupons, and discount options
• RxAssist (rxassist.org) — comprehensive resource for patient assistance programs
• RxHope (rxhope.com) — helps connect patients with manufacturer assistance programs

Fertility-Specific Financial Assistance

Several organizations provide grants and financial assistance specifically for fertility treatment costs:

• Baby Quest Foundation — fertility treatment grants
• The Cade Foundation — family-building grants
• Pay It Forward Fertility Foundation — financial assistance for IVF

While these grants typically cover broader treatment costs rather than specific medications, they can free up budget that helps cover medication expenses.

Other Ways to Save

Ask About Insurance Coverage

If you have health insurance, check whether Endometrin is covered under your plan's pharmacy benefit. Coverage varies widely:

• Some commercial plans cover fertility medications including Endometrin, sometimes with prior authorization
• Plans in states with fertility insurance mandates may be more likely to cover it
• Even plans that don't cover IVF procedures may cover the medications separately under the pharmacy benefit
• Your clinic's financial coordinator can often help navigate insurance coverage

Compare Pharmacy Prices

Prices for the same medication can vary dramatically between pharmacies — sometimes by hundreds of dollars. Always check prices at multiple pharmacies before filling. Tools like GoodRx and Medfinder make comparison easy.

Consider Prometrium as a Lower-Cost Alternative

If cost is a major barrier, discuss with your doctor whether generic Progesterone capsules (the generic equivalent of Prometrium) could work for your treatment plan. Used vaginally off-label, generic Progesterone capsules cost as little as $35 for a 90-day supply with a coupon — a fraction of Endometrin's cost. This isn't appropriate for everyone, but it's worth discussing with your reproductive endocrinologist. See our guide to Endometrin alternatives for more details.

Buy in Bulk When Possible

If your pharmacy offers a better per-unit price when you buy a larger quantity, and your insurance or coupon allows it, consider filling a larger supply at once. Some specialty pharmacies offer better pricing for a full treatment course compared to weekly refills.

Final Thoughts

No one should have to choose between their fertility treatment and their finances. While Endometrin's retail price is steep, the combination of coupon cards, manufacturer savings programs, patient assistance, and lower-cost alternatives means most patients can find a way to make it work.

Here's your action plan:

1. Check GoodRx and SingleCare for the best coupon price at pharmacies near you
2. Ask about the generic Progesterone vaginal insert
3. Enroll in Ferring's h.e.a.r.t.+ Savings Card
4. Check your insurance coverage
5. Explore patient assistance programs if you qualify
6. Talk to your doctor about lower-cost alternatives like Prometrium

Need help finding Endometrin in stock? Use Medfinder to search pharmacy availability near you. And for more information about the drug itself, check out our posts on what Endometrin is and what side effects to expect.