Comprehensive medication guide to Prometrium including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
Generic Progesterone is typically covered on Tier 1 or Tier 2 formularies, costing most patients $0 to $30 per month with insurance.
Estimated Cash Pricing
Generic Progesterone capsules cost $12 to $50 with discount cards for a 30-count supply, while brand-name Prometrium runs $1,800 to $1,900 for 90 capsules.
Medfinder Findability Score
60/100
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Prometrium is a brand-name prescription medication containing micronized progesterone, a bioidentical form of the hormone progesterone that is chemically identical to what the body naturally produces. It is manufactured by Virtus Pharmaceuticals, LLC.
Prometrium is FDA-approved for two primary uses:
It is also widely used off-label for luteal phase support in IVF and fertility treatments, prevention of preterm birth, hormone replacement therapy (HRT), and management of premenstrual syndrome (PMS).
Important: Prometrium capsules contain peanut oil and are contraindicated in patients with peanut allergies.
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![How to Find a Doctor Who Can Prescribe Prometrium Near You [2026 Guide]](/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2Fvur4atr4%2Fproduction%2F7970c650d5849203c8a3d2b09455c0084b0f85c0-1024x1024.png%3Frect%3D0%2C256%2C1024%2C512%26w%3D400%26h%3D200%26auto%3Dformat&w=828&q=75)
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Prometrium contains micronized progesterone, which binds to progesterone receptors in the uterine lining (endometrium). This transforms a proliferative endometrium into a secretory one, which protects against endometrial hyperplasia caused by unopposed estrogen therapy.
Progesterone also plays a critical role in maintaining pregnancy and regulating the menstrual cycle. The micronized formulation improves oral bioavailability compared to non-micronized progesterone. Taking Prometrium with food further increases absorption.
Prometrium is typically taken at bedtime because it commonly causes drowsiness and dizziness.
100 mg oral capsule — capsule
available in both brand-name Prometrium and generic Progesterone
200 mg oral capsule — capsule
available in both brand-name Prometrium and generic Progesterone
Prometrium and its generic equivalent, Progesterone capsules, have been experiencing intermittent shortages since late 2023. As of October 2025, ASHP listed Progesterone capsules — including both brand-name Prometrium and generic versions from Amneal Pharmaceuticals — as being in shortage. The shortages are driven by increased demand from off-label fertility and hormone replacement therapy (HRT) use, manufacturing delays, and a limited number of generic manufacturers.
With a findability score of 60 out of 100, Prometrium can be difficult to locate at times, particularly the generic formulation. You may need to call multiple pharmacies or use tools like Medfinder to check stock availability near you. Brand-name Prometrium may be slightly easier to find but comes at a significantly higher price point.
Several types of healthcare providers commonly prescribe Prometrium:
Telehealth providers can also prescribe Prometrium, making it accessible even if you don't have a local specialist.
No, Prometrium is not a controlled substance. It is not scheduled by the DEA. This means it can be prescribed without the additional restrictions that apply to controlled medications, and refills are generally straightforward. Prometrium can also be prescribed via telehealth visits.
The most frequently reported side effects of Prometrium include:
Serious side effects are rare but can include blood clots, stroke, heart attack, and severe allergic reactions. Contact your doctor immediately if you experience chest pain, sudden severe headache, vision changes, or leg swelling.
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Medroxyprogesterone (Provera)
a synthetic progestin used for endometrial protection and amenorrhea. Less expensive than Prometrium but not bioidentical.
Norethindrone Acetate (Aygestin)
a synthetic progestin used for endometriosis, amenorrhea, and abnormal uterine bleeding.
Endometrin (vaginal Progesterone insert)
a vaginal Progesterone insert used primarily for luteal phase support in fertility treatments. Delivers Progesterone locally with fewer systemic side effects.
Compounded Progesterone
custom-compounded bioidentical Progesterone available from compounding pharmacies. Not FDA-approved but used when commercial products are unavailable.
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Ketoconazole and other strong CYP3A4 inhibitors
moderatecan increase Progesterone levels in your body
St. John's Wort
moderatea CYP3A4 inducer that may decrease Progesterone levels and reduce efficacy
Rifampin
moderatemay significantly reduce Prometrium's effectiveness
Carbamazepine, Phenytoin, Phenobarbital
moderateanticonvulsants that can decrease Progesterone levels
Grapefruit juice
moderatemay increase Progesterone levels through CYP3A4 inhibition
Prometrium is an important bioidentical Progesterone medication used by thousands of women for hormone replacement, menstrual disorders, and fertility support. While the ongoing shortage of Progesterone capsules — affecting both brand-name Prometrium and generic versions — can make finding this medication frustrating, it is still possible to locate with some persistence.
Generic Progesterone capsules are very affordable with discount cards ($12 to $50 for a 30-day supply), and most insurance plans cover them on lower formulary tiers. If you're having trouble finding Prometrium in stock, try using Medfinder to check pharmacy availability near you, ask your pharmacist about expected restock dates, or discuss alternative Progesterone formulations with your doctor.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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