Finding a Doctor Who Can Prescribe Rezdiffra

If you've been diagnosed with nonalcoholic steatohepatitis (NASH) — now called metabolic dysfunction-associated steatohepatitis (MASH) — and your liver fibrosis has progressed to stage F2 or F3, you may be a candidate for Rezdiffra (Resmetirom). But getting a prescription isn't as simple as visiting your primary care doctor. Rezdiffra is a specialty medication, and not every provider is familiar with it yet.

This guide walks you through how to find the right doctor, what to expect at your first appointment, and how to move forward once you have a prescription in hand.

What Type of Doctor Prescribes Rezdiffra?

Rezdiffra was approved by the FDA in March 2024 for noncirrhotic NASH/MASH with moderate to advanced liver fibrosis. Because of its specialized indication, the doctors most likely to prescribe it include:

• Hepatologists — Liver specialists who diagnose and treat conditions like NASH, cirrhosis, and fatty liver disease. They are the most likely to be familiar with Rezdiffra.
• Gastroenterologists (GI doctors) — Many GI doctors manage liver disease as part of their practice, especially those with a focus on hepatology.
• Endocrinologists — Since NASH/MASH is closely linked to metabolic syndrome, diabetes, and obesity, some endocrinologists may prescribe Rezdiffra as part of a comprehensive metabolic treatment plan.
• Internal medicine physicians — In some cases, internists who manage complex chronic conditions may prescribe Rezdiffra, particularly if they have experience with liver disease.

In most cases, you'll need a confirmed diagnosis of NASH/MASH with F2 or F3 fibrosis before a doctor will consider prescribing Rezdiffra. This typically requires imaging, blood work, or a liver biopsy.

How to Find a Provider Who Prescribes Rezdiffra

Not every specialist is prescribing Rezdiffra yet. Here are the most effective ways to find one near you:

1. Use Your Insurance Directory

Start by logging into your health insurance portal or calling the number on the back of your insurance card. Search for in-network hepatologists or gastroenterologists in your area. When you call to schedule, ask specifically: "Does the doctor have experience prescribing Rezdiffra for NASH?"

2. Search on Zocdoc or Healthgrades

Online platforms like Zocdoc, Healthgrades, and Vitals let you search for specialists by condition and location. Search for "hepatologist" or "fatty liver disease" near your zip code. Check reviews and look for providers who mention NASH or MASH in their profiles.

3. Ask for a Referral from Your Primary Care Doctor

Your primary care provider (PCP) can refer you to a hepatologist or GI doctor. If your PCP isn't familiar with Rezdiffra, that's okay — the specialist they refer you to likely will be. A referral also helps with insurance, since many plans require one before covering a specialist visit.

4. Contact Madrigal Patient Support

Madrigal Pharmaceuticals, the maker of Rezdiffra, offers a patient support program that can help connect you with prescribers in your area. Call 1-877-219-7770 (Monday–Friday, 8 AM–8 PM ET) or visit madrigalpatientsupport.com to learn more.

5. Check Academic Medical Centers

Large academic hospitals and university health systems are often the first to adopt new treatments. If you live near a medical center with a liver disease or hepatology department, that's a strong starting point.

6. Consider Telehealth (With Limitations)

Because Rezdiffra requires confirmed fibrosis staging and ongoing liver monitoring, fully remote prescribing is uncommon. However, some hepatologists offer telehealth consultations for initial evaluations, follow-ups, or second opinions. You may still need in-person labs and imaging.

What to Expect at Your Appointment

Once you've found a specialist, here's what to prepare for:

• Medical history review — Your doctor will want to know your history of liver disease, metabolic conditions (diabetes, obesity, high cholesterol), and any prior imaging or biopsy results.
• Fibrosis staging — If you haven't already had fibrosis assessed, your doctor may order a FibroScan (transient elastography), blood-based fibrosis panels (like FIB-4 or ELF), or in some cases a liver biopsy.
• Medication review — Rezdiffra has important drug interactions, especially with statins and CYP2C8 inhibitors like Gemfibrozil. Bring a list of all your current medications.
• Weight check — Your dose of Rezdiffra depends on your body weight: 80 mg daily for patients under 220 lbs (100 kg), or 100 mg daily for patients 220 lbs or more.
• Lab work — Expect baseline liver function tests and possibly lipid panels before starting treatment.

The appointment may feel thorough, but this is a good thing. Rezdiffra is a powerful medication, and your doctor needs to make sure it's the right fit for you.

After You Get Your Prescription

Getting the prescription is just the first step. Here's what comes next:

Prior Authorization

Most insurance plans require prior authorization (PA) before covering Rezdiffra. Your doctor's office will typically handle the PA paperwork, but it can take several days to a few weeks. Be patient, and don't hesitate to follow up with both your doctor's office and your insurer.

Specialty Pharmacy

Rezdiffra is distributed through specialty pharmacies, not your local CVS or Walgreens. Your doctor or the Madrigal support team will help connect you with an approved specialty pharmacy. For tips on locating availability, see our guide on how to find Rezdiffra in stock near you.

Cost and Savings

Rezdiffra costs approximately $3,950–$4,116 per month without insurance. If you have commercial insurance, the Madrigal Copay Savings Card may reduce your out-of-pocket cost to as little as $0. For more details on savings options, check out our post on how to save money on Rezdiffra.

Ongoing Monitoring

Once you start Rezdiffra, your doctor will want to monitor your liver function regularly. Expect follow-up labs and appointments every few months, especially in the first year of treatment.

Final Thoughts

Finding a doctor who can prescribe Rezdiffra takes a bit more effort than filling a typical prescription, but it's absolutely doable. Start with a hepatologist or gastroenterologist, use your insurance directory and online tools, and don't hesitate to reach out to Madrigal's patient support line for help.

If you're ready to take the next step, use Medfinder to check pharmacy availability and get connected with the resources you need.