What Is Ozempic?

Ozempic (semaglutide) is a GLP-1 receptor agonist manufactured by Novo Nordisk. It is FDA-approved as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is also approved for the reduction of risk of major adverse cardiovascular events (cardiovascular death, nonfatal heart attack, nonfatal stroke) in adults with type 2 diabetes and established cardiovascular disease.

Ozempic is administered as a once-weekly subcutaneous injection in the abdomen, thigh, or upper arm. It is not approved for weight loss (that indication belongs to Wegovy, which contains the same active ingredient at a higher dose), though it is widely used off-label for that purpose.

How does Ozempic work?

Semaglutide mimics the naturally occurring hormone GLP-1 (glucagon-like peptide-1), which is released after eating. It works through several mechanisms:

• Stimulates insulin secretion from the pancreas in a glucose-dependent manner (only when blood sugar is elevated)
• Suppresses glucagon release, reducing the liver's glucose output
• Slows gastric emptying, which helps control post-meal blood sugar spikes
• Acts on the brain to reduce appetite and food intake

These combined effects lead to improved blood sugar control and, in many patients, significant weight loss.

What doses are available for Ozempic?

• 0.25 mg weekly — Starting dose for the first 4 weeks
• 0.5 mg weekly — First maintenance dose
• 1 mg weekly — Higher maintenance dose if additional glycemic control is needed
• 2 mg weekly — Maximum dose for patients needing further A1C reduction

Ozempic comes in pre-filled, disposable, single-patient-use subcutaneous injection pens.

How hard is it to find Ozempic in stock?

As of 2026, Ozempic is generally available at most pharmacies. The FDA officially removed semaglutide from the drug shortage list on February 21, 2025, after a nearly 3-year shortage driven by unprecedented demand for off-label weight loss use. While supply has stabilized, some patients may still encounter occasional stock issues at specific pharmacies due to continued high demand. Using a tool like Medfinder can help you quickly locate pharmacies with Ozempic in stock near you.

Who Can Prescribe Ozempic?

Ozempic can be prescribed by a variety of healthcare providers, including:

• Endocrinologists — Specialists in diabetes and hormonal conditions
• Primary Care / Family Medicine physicians
• Internal Medicine doctors
• Obesity Medicine specialists
• Cardiologists — Particularly for patients with cardiovascular risk

Ozempic is also available through telehealth platforms, making it easier to get a prescription without an in-person visit. Use Medfinder to find providers near you who prescribe Ozempic.

Is Ozempic a controlled substance?

No. Ozempic is not a controlled substance and has no DEA scheduling. It does not carry a risk of abuse or dependence. However, it does require a prescription from a licensed healthcare provider.

Common Side Effects of Ozempic

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Constipation
• Decreased appetite
• Headache
• Fatigue
• Dyspepsia (indigestion)
• Dizziness

Most GI side effects are most common during dose escalation and tend to improve over time. Serious but rare side effects include pancreatitis, gallbladder problems, and diabetic retinopathy complications. Ozempic carries a boxed warning about thyroid C-cell tumors observed in rodent studies.

Alternative Medications to Ozempic

• Mounjaro (tirzepatide) — A dual GIP/GLP-1 receptor agonist by Eli Lilly. FDA-approved for type 2 diabetes. Weekly injection with studies showing up to 2.4% A1C reduction and up to 22.5% body weight loss at the highest dose.
• Wegovy (semaglutide 2.4 mg) — Same active ingredient as Ozempic but FDA-approved specifically for chronic weight management at a higher dose. Also approved for cardiovascular risk reduction in adults with obesity.
• Trulicity (dulaglutide) — A GLP-1 receptor agonist by Eli Lilly. Weekly injection for type 2 diabetes. Generally considered less potent for weight loss but has proven cardiovascular benefits.
• Rybelsus (oral semaglutide) — Oral tablet form of semaglutide for type 2 diabetes. Taken daily on an empty stomach. Available in 3 mg, 7 mg, and 14 mg tablets.

Drug Interactions with Ozempic

• Insulin and sulfonylureas — Increased risk of hypoglycemia; dose reduction of insulin or sulfonylurea may be needed when starting Ozempic
• Oral contraceptives — Delayed gastric emptying may reduce absorption; consider non-oral contraceptive methods or barrier backup
• Warfarin and oral anticoagulants — Monitor INR more frequently when initiating or changing Ozempic dose
• Levothyroxine — Monitor thyroid function as absorption may be affected
• Oral medications in general — Ozempic delays gastric emptying and may impact absorption of concomitantly administered oral medications

Final Thoughts on Ozempic

Ozempic remains one of the most effective and widely prescribed GLP-1 receptor agonists for type 2 diabetes. After a nearly 3-year shortage that ended in early 2025, supply has largely normalized, though the medication's popularity means occasional stock issues may persist. With no generic available, cost remains a significant barrier — but manufacturer savings programs, insurance coverage, and patient assistance programs can dramatically reduce out-of-pocket expenses.

If you're having trouble finding Ozempic at your pharmacy, Medfinder can help you locate pharmacies with it in stock near you today.