Rezdiffra costs about $47,400/year without insurance. Learn how to save with copay cards, patient assistance programs, and discount strategies in 2026.
Let's be upfront: Rezdiffra (Resmetirom) is not a cheap medication. At a list price of approximately $47,400 per year — or about $3,950 per month — it's one of the more expensive specialty drugs on the market. For patients with MASH (metabolic dysfunction-associated steatohepatitis) who need this first-in-class treatment, the cost can feel overwhelming.
But here's the good news: most patients don't pay the full list price. Between manufacturer savings programs, insurance coverage, and patient assistance, many people can significantly reduce their out-of-pocket costs — and some pay nothing at all.
In this guide, we'll break down exactly what Rezdiffra costs in 2026 and every way you can save.
Without any insurance or discount programs, here's what you're looking at:
The price is the same regardless of dose strength. Both the 80 mg and 100 mg tablets cost roughly the same per month.
This is the cash price — what you'd pay at a specialty pharmacy without any insurance or discount applied. Retail pharmacies do not stock Rezdiffra, so this price reflects specialty pharmacy pricing.
With insurance, your cost depends on your plan's formulary, tier placement, and whether you've met your deductible:
Almost all insurance plans require prior authorization before covering Rezdiffra. This means your doctor needs to submit paperwork documenting your diagnosis and fibrosis staging before your insurer will approve the prescription.
The most significant savings tool for commercially insured patients is the Madrigal Copay Savings Card. Here are the key details:
If you have commercial insurance, this should be your first step. The copay card can eliminate your out-of-pocket cost entirely for each fill.
If you're uninsured, underinsured, or on a government insurance plan that doesn't cover Rezdiffra adequately, patient assistance programs may help:
Madrigal Pharmaceuticals offers a comprehensive support program that goes beyond the copay card:
Several independent organizations may offer additional support:
While Rezdiffra is a specialty medication not typically found on mainstream coupon platforms, some discount resources may offer savings:
Important note: Discount cards typically cannot be combined with insurance copays. They work best for uninsured patients paying cash. For a specialty drug like Rezdiffra at ~$3,950/month, the manufacturer copay card or patient assistance programs will almost always provide better savings than third-party discount cards.
Some insurance plans and specialty pharmacies offer cost savings when you fill a 90-day supply instead of monthly. This can lower your per-fill copay and reduce the number of shipments. Ask your specialty pharmacy about this option.
If your insurance denies coverage for Rezdiffra, don't give up. Work with your doctor to file an appeal. Include:
Many initial denials are overturned on appeal. Your doctor can also request a peer-to-peer review with the insurer's medical director.
Some states offer pharmaceutical assistance programs for residents who meet income criteria. Check with your state's health department or insurance commissioner for available programs.
Medfinder can help you identify specialty pharmacies that carry Rezdiffra and may offer different pricing structures. Comparing options can sometimes reveal savings opportunities.
As of 2026, there is no generic version of Rezdiffra available. Resmetirom is still under patent protection from Madrigal Pharmaceuticals, and no generic is expected in the near term. This means the brand-name pricing of ~$47,400/year will remain the standard for the foreseeable future.
The best strategy for managing costs right now is to take full advantage of the savings programs described above.
Rezdiffra's price tag is steep, but it doesn't have to be a barrier to treatment. If you have commercial insurance, the copay savings card can bring your cost down to $0. If you're uninsured or on Medicare/Medicaid, Madrigal Patient Support and independent assistance programs may be able to help.
The key is to be proactive. Enroll in the copay program before your first fill, work with your doctor on prior authorization, and don't hesitate to appeal if your insurance says no.
For help finding Rezdiffra in stock, visit Medfinder or read our guide on how to find Rezdiffra in stock near you. To learn more about the drug itself, check out what Rezdiffra is, its uses, and dosage.
You focus on staying healthy. We'll handle the rest.
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