How to Help Your Patients Save Money on Klisyri: A Provider's Guide to Savings Programs

Cost is one of the most significant barriers preventing patients from starting and completing Klisyri (tirbanibulin) treatment. With a retail price exceeding $1,900 per course, prescription abandonment is a real risk — particularly for Medicare patients and those without commercial insurance. This guide gives prescribers a comprehensive, up-to-date overview of every savings mechanism available, so your team can guide patients to the lowest possible cost and reduce treatment abandonment.

Understanding the Klisyri Cost Landscape

Klisyri (tirbanibulin 1% ointment) is a brand-name-only medication with no generic equivalent as of 2026. This creates a stark pricing gap between Klisyri and generic AK alternatives:

Klisyri retail price: Approximately $1,959–$1,967 per 5-packet course

Generic fluorouracil 5% cream: $30–$80 per course

Generic imiquimod 5% cream: $30–$80 per course

Generic diclofenac 3% gel: Widely covered by Medicare and commercial insurance

This price differential drives insurer step therapy requirements and patient cost concerns. However, with the right savings program, many patients can access Klisyri for $25–$150 — making the cost gap much more manageable.

Savings Program 1: Almirall Advantage Network (Commercially Insured Patients)

The Almirall Advantage program is the most powerful savings tool for your commercially insured patients. Prescribers should be familiar with all three tiers:

Tier 1 — Insurance covers Klisyri: Patient pays as low as $25 copay at an in-network pharmacy

Tier 2 — Commercial insurance does not cover Klisyri: Patient pays as low as $95 at an in-network pharmacy, $150 at retail

NOT eligible: Medicare Part A/B/C/D, Medicaid, TRICARE, or other federal programs

How to implement in your practice:

Enroll your practice at almiralladvantage.com or contact Almirall at 1-866-665-2782

Obtain the current list of in-network pharmacies in your region

Route Klisyri prescriptions to these pharmacies (e-prescribe directly)

Give the patient the Almirall Advantage savings card or coupon code at checkout

Home delivery is available through in-network pharmacies — offer this to patients with limited pharmacy access

Savings Program 2: GoodRx and Third-Party Discount Cards (All Patients)

GoodRx is available to all patients, including Medicare beneficiaries. At approximately $280.79 versus a retail price of $1,959, it offers roughly 86% savings — a significant benefit for patients who cannot use the Almirall copay card. Providers should consider:

Printing or texting GoodRx coupons directly to Medicare patients at prescription time

Advising patients to compare their Medicare Part D copay against the GoodRx cash price — GoodRx is sometimes lower than Part D, especially in the coverage gap (donut hole)

Note: using GoodRx does not count the purchase toward the patient's deductible — patients must choose between using GoodRx vs. insurance (not both)

Savings Program 3: Prior Authorization and Insurance Coverage

For patients with commercial insurance, pursuing prior authorization is worth the administrative effort when Klisyri is the preferred clinical choice. Upon approval, patient cost is limited to their standard specialty tier copay (typically $30–$100 per fill). Key PA documentation to include:

History of failure, contraindication, or intolerance to diclofenac 3% gel, topical 5-FU, and/or imiquimod 5%

Clinical rationale for Klisyri (adherence advantage of 5-day course, prior treatment failures, skin tolerance issues)

Documentation of AK severity and extent of field cancerization — larger areas (>25 cm²) particularly support the need for Klisyri's expanded 2024-approved treatment field

Appeal denied PAs with letter of medical necessity — denial reversal rates are meaningful with adequate documentation

Savings Program 4: Patient Assistance Programs (Uninsured/Underinsured)

For patients who are uninsured or underinsured and cannot afford Klisyri even with discount cards, Almirall may offer a patient assistance program (PAP) that provides the medication at no cost or reduced cost based on financial need. Have your office contact Almirall medical affairs directly at 1-866-665-2782 for current program availability, income eligibility criteria, and enrollment forms. PAP enrollment typically requires provider attestation, so your participation may be needed.

Practical Office Workflow: Klisyri Access Checklist

To systematize Klisyri prescribing in your practice, use this workflow at the point of prescribing:

Identify patient insurance type: Commercial? Medicare? Medicaid? Uninsured?

Commercial: Route to Almirall Advantage Network pharmacy + provide $25 copay card

Medicare: Submit PA + provide GoodRx coupon ($280.79 approximate) as backup

Uninsured: Check PAP eligibility + provide GoodRx and Almirall Advantage ($95 in-network) options

All patients: Share medfinder as a pharmacy locator resource

For pharmacy access support, share medfinder for providers with your patients. Also see: How to Help Your Patients Find Klisyri in Stock.