What to Know About Eprontia Side Effects

Starting a new medication can be stressful, especially when you're not sure what side effects to expect. Eprontia (Topiramate oral solution) is an effective treatment for epilepsy and migraine prevention, but like all medications, it can cause side effects.

This guide covers the most common side effects, the serious ones to watch for, and when you should contact your doctor right away.

What Is Eprontia?

Eprontia is the brand name for Topiramate oral solution (25 mg/mL), made by Azurity Pharmaceuticals. It's a ready-to-use liquid with a mixed-berry flavor, designed for patients who have difficulty swallowing tablets. For a full overview, see our guide on what Eprontia is and how it works.

Eprontia is FDA-approved for:

• Epilepsy (partial-onset and primary generalized tonic-clonic seizures) in patients age 2 and older
• Migraine prevention in patients age 12 and older

Common Side Effects

Most people who take Eprontia experience some side effects, especially during the first few weeks as your body adjusts. These are generally mild and often improve over time:

• Numbness and tingling (paresthesia) — This is the most commonly reported side effect. You may feel tingling in your hands, feet, or face. It's usually not dangerous.
• Loss of appetite — Many patients notice a decreased desire to eat
• Weight loss — Related to appetite suppression; this is why Topiramate is sometimes used off-label for weight management
• Speech problems — Difficulty finding the right words or speaking fluently
• Fatigue and drowsiness — Feeling more tired than usual, especially when starting the medication
• Dizziness — May occur when standing up quickly or during the first weeks of treatment
• Nervousness — Some patients feel anxious or jittery
• Difficulty with memory and concentration — Sometimes called "brain fog" or "Topiramate fog"
• Changes in taste — Foods and drinks may taste different, especially carbonated beverages
• Diarrhea
• Nausea
• Upper respiratory tract infection

Many of these side effects are dose-related — they happen more often at higher doses. This is why doctors typically start Eprontia at a low dose and increase it slowly over several weeks.

Serious Side Effects

While uncommon, some side effects of Eprontia require immediate medical attention. Call your doctor or seek emergency care if you experience:

• Eye pain or sudden vision changes — Topiramate can cause acute myopia (sudden nearsightedness) and secondary angle-closure glaucoma. This is a medical emergency that usually happens within the first month of treatment.
• Metabolic acidosis — Symptoms include rapid breathing, fatigue, loss of appetite, and irregular heartbeat. Your doctor may check your blood bicarbonate levels periodically.
• Suicidal thoughts or behavior — Like all anti-seizure medications, Topiramate carries a small increased risk of suicidal ideation. Contact your doctor immediately if you notice changes in mood or behavior.
• Severe cognitive problems — Confusion, difficulty speaking, or significant memory problems beyond mild "brain fog"
• Kidney stones — Symptoms include severe pain in the side or back, blood in urine, and pain when urinating. Stay well-hydrated to reduce this risk.
• Decreased sweating and overheating — Especially dangerous in children. Watch for reduced sweating during hot weather or exercise and signs of heat stroke.
• High ammonia levels (hyperammonemia) — Especially when taken with Valproic Acid. Symptoms include confusion, vomiting, and extreme tiredness.
• Severe skin reactions — Stevens-Johnson syndrome or toxic epidermal necrolysis are rare but serious. Seek immediate care for widespread rash with blistering.

Specific Populations

Pregnancy

Eprontia carries a strong FDA warning about fetal harm. Topiramate increases the risk of oral clefts (cleft lip and/or palate) and babies being born small for their gestational age. Women of childbearing potential should use effective contraception while taking Eprontia. Note that Topiramate can reduce the effectiveness of hormonal birth control, so discuss backup methods with your doctor.

Breastfeeding

Topiramate passes into breast milk and may cause drowsiness and diarrhea in nursing infants. Talk to your doctor about the risks and benefits.

Children

Eprontia is approved for children age 2 and older for epilepsy. Parents should watch for decreased sweating and overheating, which is more common in pediatric patients. Make sure children stay hydrated, especially during physical activity and hot weather.

Elderly Patients

Older adults may be more sensitive to side effects like dizziness, confusion, and memory problems. Lower starting doses may be appropriate.

Kidney Impairment

Patients with reduced kidney function (CrCl below 70 mL/min) may need a lower dose, as Topiramate is primarily cleared by the kidneys.

How to Manage Common Side Effects

Here are some practical tips for dealing with Eprontia side effects:

• Tingling — Usually mild and temporary. If bothersome, your doctor may adjust the dose.
• Drowsiness — Take your evening dose closer to bedtime. Avoid driving until you know how Eprontia affects you.
• Cognitive issues — A slower dose titration may help. Keep notes and use reminders if memory is affected.
• Kidney stones — Drink plenty of water throughout the day (at least 6–8 glasses). Avoid high-oxalate foods.
• Weight loss — Eat regular, balanced meals even if your appetite is reduced. Talk to your doctor if you lose weight rapidly.
• Overheating (children) — Limit exposure to hot environments. Ensure adequate fluid intake during exercise and warm weather.

Never stop Eprontia suddenly. Stopping abruptly can trigger seizures, even in patients taking it for migraines. Always work with your doctor to taper off gradually if you need to stop.

Final Thoughts

Most people tolerate Eprontia well, especially when the dose is increased slowly. The most common side effects — tingling, appetite loss, and drowsiness — usually improve within the first few weeks. Serious side effects are rare but important to recognize early.

If you're experiencing side effects that are difficult to manage, talk to your doctor before making any changes. They may adjust your dose or discuss alternative options. And if you're having trouble finding Eprontia at your pharmacy, Medfinder can help you locate it in stock.