Alternatives to Eprontia If You Can't Fill Your Prescription

If you've been prescribed Eprontia and can't find it at your pharmacy — or the cost is too high — you may be wondering what other options are available. The good news is that Topiramate, the active ingredient in Eprontia, comes in several other formulations that may work for you.

In this guide, we'll explain what Eprontia is, how it works, and walk through the best alternatives available in 2026.

What Is Eprontia?

Eprontia is the brand name for Topiramate oral solution, a ready-to-use liquid medication (25 mg/mL) with a mixed-berry flavor. It was approved by the FDA in November 2021 and is made by Azurity Pharmaceuticals.

Eprontia is prescribed for:

• Epilepsy: Treating partial-onset seizures, primary generalized tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome in patients 2 years and older
• Migraine prevention: Reducing the frequency of migraines in patients 12 years and older

The main advantage of Eprontia is that it's a liquid. This makes it ideal for patients who can't swallow pills — such as young children, elderly patients, or people with swallowing disorders (dysphagia).

How Does Eprontia Work?

Eprontia contains Topiramate, an anticonvulsant that works through several mechanisms:

• Blocks sodium channels — reduces the abnormal electrical activity that causes seizures
• Enhances GABA activity — GABA is a calming brain chemical; Topiramate boosts its effects
• Blocks glutamate receptors — glutamate is an excitatory brain chemical; blocking it helps prevent seizures and migraines
• Inhibits carbonic anhydrase — this enzyme-blocking action contributes to some of the drug's effects (and some of its side effects)

For a deeper explanation, see: How Does Eprontia Work? Mechanism of Action Explained.

Alternatives to Eprontia

All of the alternatives below contain the same active ingredient — Topiramate — so they work the same way in your body. The differences are in the formulation (tablet vs. capsule vs. liquid), dosing schedule, and cost.

1. Generic Topiramate Tablets

What it is: Immediate-release Topiramate tablets available in 25 mg, 50 mg, 100 mg, and 200 mg strengths.

Why consider it: Generic Topiramate tablets are by far the most affordable option. With a discount coupon, a 30-day supply can cost as little as $2 to $15. They are stocked at virtually every pharmacy in the country.

Who it's best for: Patients who can swallow tablets and don't specifically need a liquid formulation. If cost or availability is your main concern, generic tablets are the most practical alternative.

Drawback: Not suitable for patients who can't swallow pills. Tablets can be split but should not be crushed (they taste very bitter).

2. Qudexy XR (Topiramate Extended-Release Capsules)

What it is: Extended-release Topiramate capsules (25 mg, 50 mg, 100 mg, 150 mg, 200 mg) taken once daily.

Why consider it: Qudexy XR capsules can be opened and sprinkled on soft food (like applesauce), making them a good option for patients who have trouble swallowing. The once-daily dosing is also more convenient than Eprontia's twice-daily schedule.

Who it's best for: Patients who want once-daily dosing or need the sprinkle option but don't require a true liquid formulation.

Drawback: Brand-name Qudexy XR can be expensive. Generic extended-release Topiramate capsules are available and more affordable.

3. Trokendi XR (Topiramate Extended-Release Capsules)

What it is: Another extended-release Topiramate capsule (25 mg, 50 mg, 100 mg, 200 mg) taken once daily.

Why consider it: Like Qudexy XR, Trokendi XR offers once-daily dosing. It's approved for the same indications as Eprontia.

Who it's best for: Patients who prefer once-daily dosing and can swallow capsules whole. Note: Trokendi XR capsules should not be opened or sprinkled — they must be swallowed intact.

Drawback: Cannot be opened or sprinkled. Alcohol must be avoided within 6 hours before and after taking it. Brand-name pricing is high.

4. Topamax (Brand-Name Topiramate Tablets)

What it is: The original brand-name Topiramate, available as tablets and sprinkle capsules.

Why consider it: Topamax sprinkle capsules (15 mg and 25 mg) can be opened and sprinkled on food, similar to Qudexy XR. This provides a non-liquid alternative for patients who can't swallow tablets.

Who it's best for: Patients (especially children) who need a sprinkle option. However, generic Topiramate sprinkle capsules are also available and more affordable.

Drawback: Brand-name Topamax is expensive (over $400 for a 60-tablet supply). Generic versions are preferred for cost savings.

How to Talk to Your Doctor About Switching

If you're considering switching from Eprontia to an alternative, here are some tips:

• Explain your situation: Let your doctor know whether the issue is availability, cost, or both
• Ask about sprinkle capsules: If you need Eprontia because of swallowing difficulties, sprinkle capsules may be a suitable compromise
• Discuss dose equivalence: Your doctor will calculate the correct dose in the new formulation — Topiramate dosing is the same across all forms
• Don't switch on your own: Always consult your prescriber before changing medications, especially with seizure medications where consistency matters

Final Thoughts

Eprontia is a great medication for patients who need liquid Topiramate, but it's not the only option. Generic Topiramate tablets are widely available and extremely affordable. Sprinkle capsules like Qudexy XR and Topamax offer a middle ground for patients who can't swallow pills.

If you're struggling to find Eprontia, try Medfinder to check availability near you, or talk to your doctor about one of these alternatives. And if cost is the main barrier, our savings guide for Eprontia can help you find coupons and assistance programs.