Eprontia Is a Liquid Form of Topiramate Used to Treat Epilepsy and Prevent Migraines

Eprontia (Topiramate oral solution, 25 mg/mL) is a brand-name prescription medication made by Azurity Pharmaceuticals. It is the first and only FDA-approved, ready-to-use liquid form of Topiramate — a well-established anticonvulsant that has been used for decades in tablet form under brand names like Topamax.

If you've been prescribed Eprontia or are researching it for yourself or a family member, this guide covers everything you need to know: what it's used for, how to take it, who should avoid it, and what it costs.

What Is Eprontia?

Here are the key facts:

• Brand name: Eprontia
• Generic name: Topiramate
• Drug class: Anticonvulsant (sulfamate-substituted monosaccharide)
• Manufacturer: Azurity Pharmaceuticals, Inc.
• Formulation: Ready-to-use oral solution, 25 mg/mL, sweet mixed-berry flavor
• Controlled substance: No — Eprontia is not a controlled substance
• Generic available: No generic Eprontia (oral solution) exists yet. Generic Topiramate is available only in tablet form.

Eprontia was developed specifically for patients who need Topiramate but cannot swallow tablets — including young children, elderly patients, and people with swallowing disorders. The liquid formulation makes it easier to measure precise doses, which is especially important for pediatric patients.

What Is Eprontia Used For?

Eprontia is FDA-approved for three main uses:

1. Epilepsy — Initial Monotherapy

For patients age 2 and older with partial-onset seizures or primary generalized tonic-clonic seizures. This means Eprontia can be used as the first and only seizure medication.

2. Epilepsy — Adjunctive (Add-On) Therapy

For patients age 2 and older as an add-on treatment for partial-onset seizures, primary generalized tonic-clonic seizures, or seizures associated with Lennox-Gastaut syndrome.

3. Migraine Prevention

For patients age 12 and older to reduce the frequency of migraine headaches. Note that Eprontia is for prevention, not for treating a migraine that's already happening.

Off-Label Uses

Topiramate (the active ingredient in Eprontia) is also used off-label for weight management (it's a component of Qsymia), bipolar disorder, alcohol use disorder, binge eating disorder, essential tremor, and neuropathic pain. These uses are not FDA-approved for Eprontia specifically.

How Is Eprontia Taken?

Eprontia is taken by mouth twice daily, with or without food. Important details:

• Measure carefully — Use the oral syringe or dosing cup provided. Do not estimate.
• Do not mix or dilute — Eprontia is ready to use as-is
• Start low, go slow — Your doctor will start you on a low dose and gradually increase it over several weeks
• Don't stop suddenly — Stopping Topiramate abruptly can trigger seizures. Always taper off under medical supervision.

Typical Doses

• Epilepsy monotherapy (adults): Up to 400 mg/day in two divided doses
• Epilepsy adjunctive therapy (adults): 200–400 mg/day in two divided doses
• Migraine prevention: 100 mg/day in two divided doses
• Pediatric epilepsy (adjunctive): 5–9 mg/kg/day in two divided doses

To learn more about how the medication works in your body, see how Eprontia works.

Who Should Not Take Eprontia?

Eprontia is not right for everyone. Do not take it if you:

• Are allergic to Topiramate or any ingredient in Eprontia
• Are pregnant or planning to become pregnant — Topiramate increases the risk of cleft lip/palate and small-for-gestational-age babies. Women of childbearing potential must use effective contraception.

Use Eprontia with caution if you have:

• Kidney problems (dose adjustment may be needed if CrCl is below 70 mL/min)
• A history of kidney stones
• Metabolic acidosis
• Liver disease

Always tell your doctor about all medications you're taking, as Topiramate has several important drug interactions.

How Much Does Eprontia Cost?

Eprontia is a brand-name medication without a generic equivalent, so it's significantly more expensive than generic Topiramate tablets:

• Retail price (no insurance): $252–$334 for 120 mL
• With discount coupons: As low as $85–$116 for 120 mL
• Generic Topiramate tablets: As low as $1.80 for a 30-day supply with a coupon

Ways to Save

• Azurity co-pay savings program — Reduces out-of-pocket costs for commercially insured patients through eVoucherRx and Voucher on Demand
• Azurity Bridge Program — Provides medication if insurance approval takes more than 48 hours
• Patient assistance programs — NeedyMeds, RxAssist, and RxHope may help uninsured patients
• Discount coupons — GoodRx, SingleCare, and others can significantly reduce the cash price

For a detailed breakdown, see our guide on saving money on Eprontia.

Insurance Coverage

Coverage varies by plan. Many insurers require prior authorization for brand-name Eprontia, and some may require step therapy — meaning you need to try generic Topiramate tablets first. Medicare Part D may cover it with restrictions.

Final Thoughts

Eprontia fills an important role as the only ready-to-use liquid Topiramate on the market. It's a good option for patients who can't swallow pills or who need precise liquid dosing. The trade-off is a higher price tag compared to generic tablets and sometimes limited pharmacy availability.

If you're looking for Eprontia, Medfinder can help you find it in stock near you. And if cost or availability is a barrier, talk to your doctor about whether alternative Topiramate formulations might work for you.