Envarsus XR in 2026: What's the Current Situation?

If you depend on Envarsus XR to protect your transplanted kidney, you know the anxiety that comes with hearing your pharmacy can't fill your prescription. Shortages and supply disruptions for specialty medications are an ongoing reality in the United States, and transplant patients are among the most vulnerable.

Here's what you need to know about Envarsus XR availability, pricing, and your options in 2026.

Is Envarsus XR Still in Shortage?

As of February 2026, Envarsus XR is not listed on the FDA's official Drug Shortage database. That's the good news. However, "not in shortage" on paper doesn't always mean it's easy to find at your local pharmacy.

Envarsus XR is a single-source brand-name medication made exclusively by Veloxis Pharmaceuticals. With no generic equivalent and only one manufacturer, even minor production or distribution disruptions can create localized shortages. Many patients report difficulty finding it at chain pharmacies, even when there's no official national shortage.

The practical reality: your pharmacy may need to special-order Envarsus XR, which can take several days. That's why planning ahead is critical.

Why Is Envarsus XR Hard to Find?

Several factors contribute to ongoing availability challenges:

• Single manufacturer: Veloxis Pharmaceuticals is the only company that makes Envarsus XR. There are no generic alternatives for this specific extended-release tablet formulation.
• Low pharmacy stocking: Because Envarsus XR is prescribed primarily by transplant specialists, most retail pharmacies don't keep it in regular inventory. It's simply not a high-volume medication at any individual pharmacy.
• Specialty distribution: Envarsus XR often moves through specialty pharmacy channels rather than standard wholesale distribution, which means it may not be available through the same supply chains your pharmacy typically uses.
• Insurance barriers: Prior authorization requirements and specialty tier placement can delay pharmacy orders, since pharmacies may wait for insurance approval before ordering.

For a deeper dive into these issues, see our post on why Envarsus XR is so hard to find.

What Does Envarsus XR Cost in 2026?

Envarsus XR is an expensive medication. Here's what you can expect:

• Cash price (without insurance): Approximately $271 to $1,500+ per month, depending on your dose and the pharmacy.
• With a discount card: Services like SingleCare can bring the cost down to around $211 per month.
• With insurance: Most commercial plans and Medicare cover Envarsus XR, but copays vary widely. Specialty tier placement can mean copays of $50 to $200+ per month even with coverage.
• Generic Tacrolimus IR (for comparison): Generic immediate-release Tacrolimus capsules cost $15 to $50 per month — but they are not interchangeable with Envarsus XR.

For detailed savings strategies, check out our guide on how to save money on Envarsus XR.

Are There New Options for Transplant Patients?

The transplant immunosuppression landscape continues to evolve, though slowly. As of 2026:

• No generic Envarsus XR has been approved. The MeltDose® extended-release technology is still under patent protection.
• Prograf (Tacrolimus IR) remains the most widely available Tacrolimus formulation, with multiple generic manufacturers keeping supply stable and prices low.
• Astagraf XL is another once-daily option but is not interchangeable with Envarsus XR.
• Research into new immunosuppressant approaches (including belatacept-based regimens) continues, but Tacrolimus-based therapy remains the standard of care for most kidney transplant patients.

If you're interested in alternatives, read our post on alternatives to Envarsus XR.

How to Find Envarsus XR in Stock

Here's your action plan:

1. Search Medfinder — check real-time pharmacy availability by medication name and zip code.
2. Contact specialty pharmacies — ask your transplant center which specialty pharmacy they partner with. Many offer home delivery.
3. Refill early — request refills 7 to 10 days before you run out to allow time for ordering and insurance processing.
4. Call Veloxis at 1-844-835-6947 — the manufacturer can help you locate stock and connect you with their patient support program.
5. Talk to your transplant team — if you're at risk of running out, they can arrange temporary alternatives while you secure your Envarsus XR supply.

For step-by-step guidance, see how to find Envarsus XR in stock near you.

Final Thoughts

The Envarsus XR supply situation in 2026 is manageable but requires proactive planning. There is no official shortage, but single-source manufacturing and limited pharmacy stocking mean you can't take availability for granted.

Your best defenses are early refills, a reliable specialty pharmacy, and tools like Medfinder to monitor availability. And as always, keep your transplant team informed — they're your most important partner in ensuring you never miss a dose.