The Creon Shortage in 2026: What's Really Going On?

If you or a loved one takes Creon (Pancrelipase) for exocrine pancreatic insufficiency (EPI), you've likely experienced the frustration of going to the pharmacy and being told it's out of stock. Creon supply issues have been a recurring problem for patients, and heading into 2026, many people are still wondering: is Creon in shortage, and when will things get better?

This article gives you the latest information on Creon's availability in 2026, explains why shortages keep happening, and provides practical steps you can take to make sure you don't go without your medication.

Is Creon Still in Shortage in 2026?

As of early 2026, Creon is not listed on the FDA's official drug shortage list, but that doesn't tell the whole story. Many patients continue to report difficulty finding certain strengths at their local pharmacies, particularly the 12,000 and 24,000 lipase unit capsules, which are the most commonly prescribed strengths for adults.

The situation varies by region. Some areas have consistent supply, while others — especially rural communities and areas served by a limited number of pharmacy chains — may experience spotty availability. This pattern of intermittent regional shortages has been ongoing since late 2022.

Why Does Creon Keep Running Short?

Several factors contribute to Creon's recurring supply issues. For a detailed breakdown, see our article on why Creon is so hard to find. Here's a summary:

• Porcine supply chain: Creon is derived from pig pancreas glands, creating a biological supply chain that's more vulnerable to disruption than synthetic drug manufacturing.
• Rising demand: More patients are being diagnosed with EPI as awareness grows, increasing prescription volume.
• Manufacturing complexity: Each batch requires extensive quality testing for potency and safety, which can slow production.
• No generics: There is no FDA-approved generic Creon. While other PERT brands exist, they have their own separate supply chains.

How Much Does Creon Cost in 2026?

Cost remains a significant concern for Creon patients. Here's what you can expect:

• Cash price (no insurance): $700–$1,500 per month, depending on your prescribed strength and dose
• With commercial insurance: Copays typically range from $30–$100 per month, depending on your plan's formulary tier
• With Medicare Part D: Creon is usually covered but may require prior authorization. Out-of-pocket costs vary by plan.
• With AbbVie Savings Card: Eligible commercially insured patients may pay as little as $0 per prescription

For a complete guide to reducing your Creon costs, read our article on how to save money on Creon in 2026.

Are There New Options for EPI Patients?

While no new pancreatic enzyme products have launched recently, the existing alternatives to Creon remain available:

• Zenpep — available in strengths up to 40,000 lipase units
• Pancreaze — available in several unique strength options
• Pertzye — contains added bicarbonate for pH buffering
• Viokace — non-enteric-coated tablets (requires a PPI, not for cystic fibrosis)

If you're having trouble finding Creon, one of these alternatives may be more readily available. See our full comparison in alternatives to Creon.

How to Find Creon in Stock Right Now

Here are the most effective strategies for locating Creon:

1. Use Medfinder

Medfinder lets you check Creon availability at pharmacies near you in real time. It's the fastest way to find stock without calling dozens of pharmacies. For a step-by-step walkthrough, see our guide on how to find Creon in stock near you.

2. Try Independent and Specialty Pharmacies

Chain pharmacies often run out first. Independent pharmacies and specialty pharmacies may have access to different distribution channels and could have the strength you need.

3. Consider Mail-Order Pharmacy

If your insurance offers mail-order pharmacy benefits, this can be a reliable way to get a 90-day supply of Creon delivered to your door. This option is especially good for patients on a stable dose.

4. Plan Ahead

Refill your prescription 5–7 days before you run out. Ask your pharmacy to set up automatic reorders. Keep a backup pharmacy identified through Medfinder's stock checker.

Final Thoughts

The Creon supply situation in 2026 is best described as "improved but not resolved." While large-scale shortages have eased, many patients still face regional and strength-specific availability gaps. The best thing you can do is stay proactive: use Medfinder to track availability, refill early, and have a conversation with your doctor about backup options.

You shouldn't have to worry about whether you'll be able to digest your next meal. With the right tools and planning, you can stay ahead of the supply issues and keep your EPI under control.