Is Bupropion still in shortage in 2026? Get the latest update on Bupropion availability, pricing, and what you can do if your pharmacy is out of stock.
If you take Bupropion for depression, seasonal affective disorder, or smoking cessation, the past few years may have tested your patience. Since 2023, certain formulations of Bupropion — particularly the extended-release (XL) tablets — have been listed on the ASHP drug shortage list, leaving patients frustrated and sometimes without their medication.
So what's the situation now? In this 2026 update, we'll cover whether Bupropion is still in shortage, what's driving the supply issues, how much it costs today, and what you can do to make sure you don't run out.
The short answer: it depends on where you are and what formulation you need.
As of early 2026, the national supply of Bupropion has improved significantly compared to the worst periods in 2023 and 2024. Several generic manufacturers — including Teva, Par Pharmaceuticals, Lupin, Cipla, and Amneal — have ramped up production. The FDA has been working with manufacturers to address supply gaps.
However, spot shortages still happen. You may find that your local CVS or Walgreens is out of Bupropion XL 300 mg while a pharmacy across town has plenty. The shortage isn't gone — it's just become more localized and unpredictable.
The formulations most affected:
Bupropion SR and Aplenzin (bupropion hydrobromide) have generally been easier to find.
The factors that created the shortage haven't fully resolved:
Bupropion remains one of the most prescribed medications in the United States, with over 29 million prescriptions annually. It's popular because it treats depression without the weight gain and sexual side effects associated with SSRIs. This high demand puts constant pressure on the supply chain.
While manufacturers have increased production, extended-release tablet manufacturing is more complex than immediate-release formulations. Quality control requirements, raw material sourcing, and FDA compliance all create bottlenecks.
Generic Bupropion is inexpensive — great for patients, but challenging for manufacturers. Thin profit margins mean companies have limited incentive to invest heavily in expanding production capacity.
For a deeper explanation, see: Why Is Bupropion So Hard to Find? [Explained for 2026].
One silver lining: Bupropion remains one of the more affordable antidepressants when you can find it.
Most patients take generic Bupropion, which is therapeutically equivalent and dramatically cheaper. For more savings strategies, check out: How to Save Money on Bupropion in 2026: Coupons, Discounts, and Patient Assistance.
Several developments may help patients in 2026:
New generic manufacturers have entered or expanded production of Bupropion XL, which should help stabilize the supply over time.
Auvelity is a newer combination medication that contains Bupropion along with dextromethorphan. It was approved in 2022 as a rapid-acting antidepressant. While it's not a direct replacement for Bupropion alone, it's an option worth discussing with your doctor — especially if you've had difficulty with other treatments. Note: Auvelity is a brand-name medication and costs significantly more than generic Bupropion.
Telehealth platforms now widely prescribe Bupropion, making it easier to get a prescription or adjust your treatment without an in-person visit. Services like Cerebral, Done, Brightside, and others offer online consultations with psychiatrists and nurse practitioners who can prescribe Bupropion.
If your pharmacy is out, here's what to do:
For a complete guide, read: How to Find Bupropion in Stock Near You (Tools + Tips).
The Bupropion shortage of 2023-2024 was one of the most disruptive medication shortages in recent memory, affecting millions of patients who depend on this medication daily. While 2026 has brought meaningful improvement, the supply situation isn't perfect.
The best thing you can do is stay proactive: refill early, use tools like Medfinder, maintain relationships with multiple pharmacies, and stay in touch with your prescriber. If Bupropion continues to be unavailable in your area, explore alternatives with your doctor so you never have to go without treatment.
You focus on staying healthy. We'll handle the rest.
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