Comprehensive medication guide to Vilazodone including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$10–$50 copay for generic; brand Viibryd may require prior authorization or step therapy.
Estimated Cash Pricing
$175–$383 retail for generic; as low as $28–$60 with GoodRx or SingleCare coupons.
Medfinder Findability Score
65/100
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Vilazodone (sold under the brand name Viibryd) is a prescription antidepressant approved by the FDA for the treatment of Major Depressive Disorder (MDD) in adults. It belongs to a unique drug class called Serotonin Partial Agonist-Reuptake Inhibitors (SPARIs), making it distinct from traditional SSRIs and SNRIs.
Originally developed by Forest Laboratories and now marketed by AbbVie (Allergan), Vilazodone is also sometimes used off-label for Generalized Anxiety Disorder, Social Anxiety Disorder, OCD, and Premenstrual Dysphoric Disorder. It must be taken with food to ensure proper absorption.
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Vilazodone works through a dual mechanism of action that sets it apart from other antidepressants:
This combined SPARI mechanism may lead to a faster onset of action and fewer sexual side effects compared to traditional SSRIs, though individual responses vary. Vilazodone is taken once daily with food, starting at 10 mg and titrating up to the target dose of 40 mg over two weeks.
10 mg oral tablet (starting dose) — tablet
20 mg oral tablet (intermediate dose) — tablet
40 mg oral tablet (target/maintenance dose) — tablet
Vilazodone (brand name Viibryd) is not currently on the FDA or ASHP drug shortage lists as of March 2026. However, because it is a less commonly prescribed antidepressant compared to mainstream SSRIs like Sertraline or Fluoxetine, many pharmacies — especially smaller or rural locations — may not keep it in regular stock and may need to special order it. Generic Vilazodone is available, which helps with both cost and availability, but you may still need to call ahead to confirm your pharmacy has it on hand.
If your local pharmacy doesn't carry Vilazodone, try larger chain pharmacies (CVS, Walgreens, Walmart) or use Medfinder to locate pharmacies near you that have it in stock.
Vilazodone can be prescribed by a range of healthcare providers, including:
Vilazodone is also available through telehealth platforms, making it accessible for patients who prefer virtual visits. Use Medfinder to find providers who can prescribe Vilazodone near you.
No, Vilazodone is not a controlled substance. It is not scheduled by the DEA and does not carry abuse potential restrictions. You can receive standard prescriptions with refills, and it can be prescribed via telehealth without the restrictions that apply to controlled substances.
However, Vilazodone should not be stopped abruptly — your doctor will recommend a gradual taper to avoid discontinuation symptoms such as irritability, dizziness, and nausea.
The most frequently reported side effects of Vilazodone include:
Important: Vilazodone carries an FDA boxed warning about increased risk of suicidal thoughts and behaviors in young adults under 25. Contact your healthcare provider immediately if you experience worsening depression or suicidal thoughts. Serious but rare side effects include serotonin syndrome, seizures, abnormal bleeding, and hyponatremia (low sodium).
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Vortioxetine (Trintellix)
A multimodal serotonin modulator for MDD with cognitive benefits. Also a newer-generation antidepressant with a unique mechanism.
Sertraline (Zoloft)
A widely used, affordable generic SSRI and common first-line treatment for depression and anxiety disorders.
Fluoxetine (Prozac)
An SSRI used for depression, OCD, panic disorder, and bulimia. Very affordable generic with a long half-life.
Duloxetine (Cymbalta)
An SNRI used for depression, generalized anxiety, and chronic pain. Available as a generic with dual serotonin-norepinephrine activity.
Prefer Vilazodone? We can find it.
MAO Inhibitors
moderate(Isocarboxazid, Phenelzine, Tranylcypromine, Selegiline) — Do not combine. Must wait 14 days between stopping one and starting the other. Risk of life-threatening serotonin syndrome.
Strong CYP3A4 Inhibitors
moderate(Ketoconazole, Itraconazole, Clarithromycin) — Vilazodone dose should be reduced to 20 mg/day.
Strong CYP3A4 Inducers
moderate(Carbamazepine, Rifampin, Phenytoin) — Vilazodone dose may need to increase up to 80 mg/day.
Other Serotonergic Drugs
moderate(Triptans, Tramadol, St. John's Wort, other antidepressants) — Increased risk of serotonin syndrome.
Linezolid and IV Methylene Blue
moderateRisk of serotonin syndrome; contraindicated.
Anticoagulants (Warfarin), NSAIDs, and Aspirin
moderateIncreased bleeding risk.
Diuretics
moderateIncreased risk of hyponatremia.
Vilazodone (Viibryd) is a unique antidepressant that offers a dual mechanism of action — combining SSRI-like serotonin reuptake inhibition with 5-HT1A partial agonism. This makes it a valuable option for patients with Major Depressive Disorder, particularly those who have experienced sexual side effects or inadequate response with traditional SSRIs.
While Vilazodone is not on any active shortage lists, it is less commonly stocked than mainstream antidepressants. Generic Vilazodone is available and significantly more affordable than brand Viibryd, especially with discount coupons from GoodRx or SingleCare that can bring the price as low as $28–$60 per month. If you're having trouble finding Vilazodone at your local pharmacy, use Medfinder to locate pharmacies with it in stock near you.
Always take Vilazodone with food, follow your doctor's titration schedule, and never stop the medication abruptly without medical guidance.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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