Bijuva Shortage Update: What Patients Need to Know in 2026

Bijuva in 2026: Is There a Shortage?

If you've been told your pharmacy can't fill your Bijuva prescription, you're probably wondering: is Bijuva in shortage? The short answer is complicated. Bijuva is not on the FDA's official drug shortage list, but many patients across the country report difficulty finding it at their local pharmacies.

This article breaks down the current state of Bijuva availability in 2026, explains why you might be having trouble, and gives you concrete steps to get your medication.

Is Bijuva Still in Shortage?

As of early 2026, Bijuva (Estradiol 1 mg or 0.5 mg / Progesterone 100 mg) is not listed on the FDA's official drug shortage database. However, that doesn't mean it's easy to find. The FDA shortage list tracks issues reported directly by manufacturers, and the availability challenges with Bijuva are driven more by distribution and stocking patterns than by a true manufacturing shortage.

What patients are experiencing is a practical shortage — the drug exists in the supply chain, but many retail pharmacies don't keep it on their shelves. This distinction is important because it means Bijuva can usually be obtained if you know where to look.

Why Is Bijuva Hard to Find?

Several factors contribute to the ongoing difficulty in finding Bijuva. For a complete breakdown, see our detailed guide on why Bijuva is so hard to find in 2026.

No Generic Available

Bijuva remains a brand-name-only medication. No generic version has been approved by the FDA, and with 24 active patents, a generic may not be available for several years. This means only one company — Mayne Pharma — manufactures the product, making the supply chain vulnerable to any disruption.

Pharmacy Stocking Decisions

With a cash price of $257 to $351 per month, Bijuva is expensive for pharmacies to keep in inventory. Retail chains make stocking decisions based on demand volume, and a niche brand-name hormone therapy doesn't always justify shelf space at every location.

Manufacturer Transition

The commercial rights for Bijuva transferred from TherapeuticsMD to Mayne Pharma in late 2022. While this transition is now largely complete, it caused some distribution disruptions that took time to fully resolve in all markets.

Increased Demand

Growing awareness of bioidentical hormone therapy — and Bijuva's unique position as the only FDA-approved bioidentical estradiol-plus-progesterone combination — has driven up demand. More prescriptions are being written, but pharmacy stocking hasn't always kept pace.

What Does Bijuva Cost in 2026?

Understanding the cost landscape helps explain some of the availability challenges:

• Cash price (no insurance): $257 to $351 for 30 capsules
• With manufacturer copay card + commercial insurance: As low as $35 per month
• With manufacturer copay card (cash-paying patients): As low as $75 per month
• With discount coupons (GoodRx, SingleCare): Varies, typically $240 to $320

For a full guide on savings options, see how to save money on Bijuva in 2026.

Are There New Options in 2026?

While no generic Bijuva has been approved, there are other developments worth knowing about:

• Separate bioidentical prescriptions: Your doctor can prescribe generic Estradiol tablets plus generic Progesterone (Prometrium) capsules separately. This provides the same two hormones for as little as $25 to $70 per month combined.
• Other combination HRT products: Prempro and Activella are combination estrogen-progestogen tablets with generic versions available, costing $15 to $60 per month.
• Compounded bioidentical hormones: While not FDA-approved, compounded bioidentical estradiol and progesterone preparations remain available through compounding pharmacies for patients who prefer that route.

Read more about these in our guide to alternatives to Bijuva.

How to Find Bijuva in Stock

If you want to stay on Bijuva, here are the most effective strategies for finding it:

1. Use Medfinder

Medfinder can show you which pharmacies near your zip code currently have Bijuva available. This is the fastest way to avoid wasted phone calls and trips. Check out our step-by-step guide on how to check pharmacy stock for Bijuva.

2. Try Independent Pharmacies

Independent pharmacies are more likely to carry or order niche brand-name medications like Bijuva. They may also provide more personalized service in helping you track down your medication.

3. Set Up Auto-Refills

Once you find a pharmacy that carries Bijuva, set up automatic refills. This signals to the pharmacy that there's ongoing demand, making them more likely to keep it in stock.

4. Explore Mail-Order Options

Mail-order pharmacies affiliated with your insurance plan may carry Bijuva more reliably than local retail pharmacies.

5. Contact Mayne Pharma

The manufacturer's patient support line (1-844-825-8500) can sometimes help locate pharmacies with available stock in your area.

Final Thoughts

Bijuva isn't in a formal FDA shortage, but finding it at your pharmacy in 2026 can feel like a scavenger hunt. The core issue is that it's a brand-only specialty product in a market that favors generics and high-volume medications. With tools like Medfinder, independent pharmacies, and the manufacturer copay card, most patients can still get their hands on Bijuva.

If you're running out of options, talk to your doctor about alternative hormone therapy medications. And for more on Bijuva, explore our guides on what Bijuva is, side effects to watch for, and drug interactions to avoid.