Is Amoxicillin/Clarithromycin/Lansoprazole Still in Shortage?

If you've been prescribed Amoxicillin/Clarithromycin/Lansoprazole (sold as Prevpac) for an H. pylori infection and struggled to find it at the pharmacy, you may be wondering: is there a shortage?

The answer is nuanced. As of 2026, the pre-packaged Prevpac combination kit is not formally listed on the FDA's drug shortage database. However, many patients still report difficulty finding it at their local pharmacy. Here's why — and what you can do about it.

Why Is It Still Hard to Find?

Even without an official shortage, several factors make this medication harder to locate than most prescriptions:

The Combination Kit Has Low Demand

Most pharmacies have shifted away from stocking the pre-packaged Prevpac kit. Doctors increasingly prescribe the three components separately — Lansoprazole, Amoxicillin, and Clarithromycin — which are cheaper and easier for pharmacies to manage. As a result, many pharmacies simply don't order the combination pack anymore.

Amoxicillin Supply Disruptions

Amoxicillin, one of the three components, experienced significant supply disruptions beginning in late 2022 and continuing through 2023. A surge in respiratory illnesses drove up demand for this widely used antibiotic, and manufacturers struggled to keep pace. While supply has largely stabilized by 2026, some regions — particularly rural areas — still experience occasional gaps.

Fewer Manufacturers

The number of companies producing the pre-packaged triple therapy kit has declined. When fewer manufacturers are making a product, any production delay or quality issue can quickly create regional shortages.

Clarithromycin Prescribing Has Declined

Growing awareness of Clarithromycin resistance among H. pylori strains has led many gastroenterologists to recommend alternative first-line treatments. This reduced demand means pharmacies stock less Clarithromycin, which can create a catch-22 for patients who are prescribed the traditional triple therapy.

What Does It Cost in 2026?

Cost remains a significant barrier for patients without insurance coverage:

• Brand-name Prevpac kit: $800–$900 retail price
• Generic combination kit: $400–$600 retail, or as low as $241 with a GoodRx coupon
• Individual generic components purchased separately: $30–$50 total with discount coupons
• With most insurance plans: $10–$75 co-pay

The cost difference between the pre-packaged kit and individual components is dramatic. If your pharmacy doesn't have the combination kit, getting separate prescriptions can save you hundreds of dollars. For a complete breakdown of savings options, see our guide to saving money on this medication.

Are There New Options for H. Pylori Treatment?

Yes. The H. pylori treatment landscape has expanded significantly in recent years:

• Voquezna Dual Pak (Vonoprazan/Amoxicillin): FDA-approved in 2022, this newer regimen uses a more potent acid blocker and requires just two medications instead of three. It offers a simpler dosing schedule.
• Talicia (Omeprazole/Amoxicillin/Rifabutin): FDA-approved for H. pylori, this combination is effective against Clarithromycin-resistant strains.
• Bismuth Quadruple Therapy: Now recommended as a first-line option by the American College of Gastroenterology, this regimen uses a PPI, Bismuth Subsalicylate, Metronidazole, and Tetracycline.

Learn more about all your options in our guide to alternatives.

How to Find It in Stock Right Now

If your doctor specifically prescribed the Amoxicillin/Clarithromycin/Lansoprazole combination, here's how to find it:

Step 1: Search on Medfinder

Use Medfinder to check real-time pharmacy availability near your zip code. It's the fastest way to see which pharmacies have the medication without making a dozen phone calls.

Step 2: Check Independent Pharmacies

Independent pharmacies are more likely to have the combination kit or to order it quickly from their wholesaler. Call a few in your area — they're often more helpful with specialty medications.

Step 3: Ask About Separate Prescriptions

If the combination kit is unavailable, contact your doctor's office and ask them to send three separate prescriptions to your pharmacy:

• Lansoprazole 30 mg (take 1 capsule twice daily before meals)
• Amoxicillin 500 mg (take 2 capsules twice daily)
• Clarithromycin 500 mg (take 1 tablet twice daily)

This is medically equivalent to the combination kit and is almost always available.

Step 4: Use Discount Coupons

If you're paying out of pocket, check GoodRx, SingleCare, or RxSaver for coupons. The individual generics with coupons are dramatically cheaper than the combination pack.

Final Thoughts

While there's no official FDA shortage of Amoxicillin/Clarithromycin/Lansoprazole in 2026, the practical reality is that many patients still struggle to find the pre-packaged combination kit at their pharmacy. The good news is that the individual components are widely available and much more affordable.

Don't delay your H. pylori treatment. Use Medfinder to find it in stock, ask about separate prescriptions, and explore discount options to keep costs down. And if you want to understand more about the drug itself, check out our articles on what this medication is and what side effects to expect.