A Full Course of H. Pylori Treatment Could Cost You $900 — Or Under $50

If you've been prescribed Amoxicillin/Clarithromycin/Lansoprazole (also known as Prevpac) for an H. pylori infection, you may have experienced sticker shock at the pharmacy. The retail cash price for a full 14-day treatment course can reach $800 to $900 without insurance.

But here's what most people don't know: with the right approach, you can get the same treatment for under $50. This guide walks you through every savings option available in 2026 — from free coupon cards to patient assistance programs.

How Much Does Amoxicillin/Clarithromycin/Lansoprazole Cost Without Insurance?

The cost depends on whether you're filling the pre-packaged combination kit or the three individual medications:

• Brand-name Prevpac combination kit: $800–$900 retail
• Generic combination kit (cash price): $400–$600 retail
• Generic combination kit with coupon: As low as $241 (GoodRx)
• Individual generic components at retail: Lansoprazole ~$20, Amoxicillin ~$8, Clarithromycin ~$30 = ~$58 total
• Individual generic components with coupons: Lansoprazole ~$10, Amoxicillin ~$4, Clarithromycin ~$15 = ~$29 total

The takeaway is clear: buying the three medications separately with discount coupons is the most affordable option, often costing less than $50 for the entire treatment course.

Option 1: Prescription Discount Coupons and Cards

Prescription discount coupons are free to use and can be combined with paying cash (not insurance). Here are the best options for this medication:

GoodRx

GoodRx is one of the most popular discount platforms and offers significant savings on all three components:

• Generic Prevpac kit: As low as $241 (vs. $890 retail) — a savings of about 73%
• Lansoprazole 30 mg (28 capsules): As low as $8-$12
• Amoxicillin 500 mg (56 capsules): As low as $4-$8
• Clarithromycin 500 mg (28 tablets): As low as $12-$20

Visit goodrx.com, search for each medication, and show the coupon at your pharmacy. It's free — no sign-up or membership required.

SingleCare

SingleCare offers comparable discounts and is accepted at most major pharmacies, including CVS, Walgreens, Walmart, and Kroger. Check singlecare.com for prices on each of the three medications.

RxSaver

RxSaver compares prices across multiple discount programs and pharmacies. It can help you find the absolute lowest price in your area by searching rxsaver.com.

Other Discount Cards Worth Checking

For potentially lower prices at specific pharmacies, also check:

• BuzzRx (buzzrx.com)
• Optum Perks (perks.optum.com)
• ScriptSave WellRx (wellrx.com)
• America's Pharmacy (americaspharmacy.com)

Prices vary by pharmacy and location, so comparing across 2-3 coupon platforms can save you an extra $5-$15.

Option 2: Walmart, Costco, and $4 Generic Programs

Several retail pharmacies offer flat-rate generic drug programs that can make individual components extremely affordable:

• Walmart $4 Generics: Amoxicillin is typically included in Walmart's $4 generic program. Lansoprazole may also qualify. Check walmart.com or ask at the pharmacy counter.
• Costco Pharmacy: Costco consistently offers some of the lowest prescription prices, and you don't need a Costco membership to use the pharmacy. Prices for the three components are often competitive with or lower than coupon-card prices.
• Kroger, Publix, and other grocery chains: Many offer generic discount programs. Amoxicillin is frequently included in free or $4 antibiotic programs.

Option 3: Patient Assistance Programs

If you're uninsured or underinsured and struggling to afford the medication, patient assistance programs (PAPs) may help:

Takeda Help at Hand

Takeda, the manufacturer of the brand-name Prevpac, offers the Help at Hand Patient Assistance Program for eligible patients who lack insurance or adequate coverage. Eligibility is typically based on income level. Learn more at helpathandpap.com or call Takeda Patient Support.

NeedyMeds

NeedyMeds (needymeds.org) maintains a database of patient assistance programs, discount drug cards, and other resources. Search for each individual component to find manufacturer and foundation programs.

RxAssist

RxAssist (rxassist.org) is a comprehensive database of patient assistance programs maintained by Volunteers in Health Care. It includes programs for many generic medications.

RxHope

RxHope (rxhope.com) connects patients with manufacturer patient assistance programs and can help with the application process.

Option 4: Other Ways to Save

Ask Your Doctor for Separate Prescriptions

This is the single most impactful step you can take. If your doctor writes one prescription for the Prevpac combination kit, ask them to instead write three separate prescriptions for Lansoprazole, Amoxicillin, and Clarithromycin. The individual generics cost $29-$50 total with coupons compared to $241-$900 for the combination kit. The medication is identical — just packaged differently.

Compare Prices Across Pharmacies

Drug prices vary dramatically from pharmacy to pharmacy. A medication that costs $40 at CVS might cost $15 at Costco. Use tools like Medfinder and GoodRx to compare prices at pharmacies near you before filling.

Use Your Insurance's Mail-Order Option

Many insurance plans offer lower co-pays for mail-order prescriptions. If your treatment timeline allows for shipping (typically 3-5 business days), this can be a cost-effective option.

Ask About Therapeutic Alternatives

If cost is a primary concern, ask your doctor about alternative H. pylori treatments. Bismuth Quadruple Therapy uses generic medications that can total $30-$80 for a full course. Levofloxacin Triple Therapy can cost as little as $20-$60 with coupons.

Final Thoughts

No one should skip H. pylori treatment because of cost. With discount coupons, separate prescriptions, and patient assistance programs, you can get a full 14-day treatment course for under $50 — or even free if you qualify for a patient assistance program.

Here's your action plan:

1. Ask your doctor for three separate prescriptions (not the combination kit)
2. Compare prices on GoodRx, SingleCare, and RxSaver
3. Check Costco and Walmart for their generic pricing programs
4. If you're uninsured, look into NeedyMeds and Takeda Help at Hand

For help finding this medication in stock near you, visit Medfinder. For more information about the drug itself, read What Is Amoxicillin/Clarithromycin/Lansoprazole? or learn about side effects and what to expect.