Comprehensive medication guide to Zilxi including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
With insurance, eligible patients using the Zilxi Savings Card may pay as little as $25, though many plans require prior authorization.
Estimated Cash Pricing
Zilxi costs approximately $400–$600 per 60g canister without insurance.
Medfinder Findability Score
45/100
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Zilxi (Minocycline Topical Foam 1.5%) is a prescription topical antibiotic approved for the treatment of inflammatory lesions — specifically papules and pustules — associated with rosacea in adults. It is manufactured by Journey Medical Corporation and was the first topical minocycline foam approved by the FDA. Unlike oral minocycline, Zilxi is applied directly to the skin, which helps reduce systemic side effects while targeting facial inflammation.
Zilxi contains minocycline, a tetracycline-class antibiotic that works by reducing inflammation and inhibiting bacterial growth on the skin. When applied topically as a foam, it directly targets the inflammatory lesions of rosacea without the systemic exposure associated with oral tetracyclines. Patients apply a thin layer of foam once daily to the affected areas of the face.
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![How to Find a Doctor Who Can Prescribe Zilxi Near You [2026 Guide]](/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2Fvur4atr4%2Fproduction%2F013b542b7f417f4555a9c83c93af77168e437391-1024x1024.png%3Frect%3D0%2C256%2C1024%2C512%26w%3D400%26h%3D200%26auto%3Dformat&w=828&q=75)
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Zilxi 1.5% Topical Foam — topical
30g pressurized canister
Zilxi 1.5% Topical Foam — topical
60g pressurized canister
Zilxi scores a 45 out of 100 on our findability scale, meaning it can be difficult to locate in stock. As a branded specialty topical foam with no generic equivalent, many pharmacies do not routinely stock it. While there is no active FDA shortage, patients frequently encounter localized availability issues and may need to call multiple pharmacies or use a specialty pharmacy to obtain it.
Zilxi is most commonly prescribed by dermatologists, as rosacea is a skin condition that typically falls within their specialty. However, primary care physicians and internal medicine doctors can also prescribe it. Telehealth consultations are available for patients who may have difficulty seeing a dermatologist in person.
No, Zilxi is not a controlled substance. It is a topical antibiotic and does not have any potential for abuse or dependence. It does not require a DEA number to prescribe and can be called in or electronically sent to any pharmacy.
Serious but rare side effects may include C. difficile-associated diarrhea, hepatotoxicity, autoimmune syndromes, intracranial hypertension, serious skin reactions, photosensitivity, and tissue hyperpigmentation. Contact your healthcare provider immediately if you experience any severe or unusual symptoms.
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Metronidazole (MetroGel, MetroCream)
A topical antibiotic and first-line treatment for rosacea, available as a generic gel and cream at a lower cost.
Ivermectin (Soolantra)
A topical anti-parasitic cream approved for rosacea that targets Demodex mites contributing to inflammation.
Azelaic Acid (Finacea)
A topical gel or foam that reduces inflammation and kills bacteria, approved for rosacea.
Doxycycline (Oracea)
A low-dose oral tetracycline antibiotic often used for moderate-to-severe rosacea.
Prefer Zilxi? We can find it.
Isotretinoin (Accutane)
moderateConcomitant use increases the risk of intracranial hypertension (pseudotumor cerebri). Do not use together.
Anticoagulants (e.g., Warfarin)
moderateTetracyclines may increase the anticoagulant effect, requiring closer monitoring of INR levels.
Penicillin
moderateTetracyclines may interfere with the bactericidal action of penicillin antibiotics.
Oral Retinoids
moderateIncreased risk of intracranial hypertension when combined with tetracyclines.
Zilxi is a unique treatment option for adults with inflammatory rosacea, offering the benefits of minocycline in a targeted topical foam. However, its high cash price of $400–$600 per canister and limited pharmacy stocking can make it challenging to obtain. Patients should check with specialty pharmacies, use the manufacturer's savings card (eligible commercially insured patients may pay as little as $25), and consider alternatives like Metronidazole or Azelaic Acid if cost or availability is a barrier. Using Medfinder can help you quickly locate pharmacies that have Zilxi in stock near you.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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