Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Lexette is a brand-name prescription topical foam containing Halobetasol Propionate 0.05%, a super high potency (Class I) topical corticosteroid manufactured by Mayne Pharma. It is FDA-approved for the treatment of plaque psoriasis in patients 12 years of age and older. Lexette works by reducing inflammation, redness, itching, and scaling on the skin. It is applied as a thin layer to affected areas twice daily for up to 2 weeks, with a maximum of 50 grams per week.
Halobetasol Propionate, the active ingredient in Lexette, is a super high potency topical corticosteroid. It works by binding to intracellular glucocorticoid receptors in skin cells, which suppresses the inflammatory and immune responses. This reduces the production of inflammatory mediators such as prostaglandins and leukotrienes, leading to decreased inflammation, redness, itching, and scaling associated with plaque psoriasis. The foam formulation allows for easy application and absorption into affected skin areas.
Generic Halobetasol Propionate is also available in other formulations:
Lexette (Halobetasol Propionate 0.05% foam) has a moderate findability score of 55 out of 100. While there is no active FDA shortage, brand-name Lexette is an expensive specialty dermatological product that many pharmacies do not routinely stock. You may need to call ahead or have your pharmacy special-order it. Generic Halobetasol Propionate is more widely available in cream and ointment forms, but the foam formulation (which is what Lexette specifically is) may have limited generic availability. Insurance formulary restrictions and prior authorization requirements can also delay access.
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Lexette is most commonly prescribed by:
Telehealth consultations are also available for obtaining Lexette prescriptions, which can be convenient if you need a refill or initial evaluation.
No, Lexette is not a controlled substance. It does not have a DEA schedule classification and does not carry the same prescribing restrictions as controlled medications. However, its use is limited to 2 weeks maximum due to the risk of HPA (hypothalamic-pituitary-adrenal) axis suppression, and it requires a valid prescription from a licensed healthcare provider.
More serious but less common side effects include HPA axis suppression (seen in 24–26% of clinical study participants), skin atrophy, stretch marks, and secondary skin infections. Do not use for longer than 2 weeks or apply more than 50 grams per week. Contact your doctor if you experience worsening symptoms or signs of skin thinning.
If you cannot find Lexette or are looking for alternatives, consider discussing these options with your doctor:
There are no significant food interactions with Lexette. Always inform your doctor of all medications you are using, including over-the-counter products and other topical treatments.
Lexette is an effective super high potency topical treatment for plaque psoriasis, but finding it at an affordable price can be challenging. At nearly $1,000 retail for a single 50g can, it's important to explore savings options. The Mayne Pharma Patient Savings Card (available at lexette.com/savings) can reduce copays to $0 for eligible commercially insured patients. For those paying cash, generic Halobetasol Propionate in cream or ointment form can be found for as low as $25 with discount coupons. If your pharmacy doesn't stock Lexette, ask them to special-order it or consider an equivalent generic formulation. Use Medfinder to locate pharmacies near you that have Lexette or its generic equivalent in stock.
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