Lexette (Halobetasol Propionate foam 0.05%) is a prescription super high potency topical corticosteroid used to treat plaque psoriasis in patients 12 years and older.

What Is Lexette?

Lexette is a brand-name topical foam made by Mayne Pharma. It contains Halobetasol Propionate 0.05%, which is classified as a Class I (super high potency) topical corticosteroid — the strongest class of topical steroid available.

The active ingredient, Halobetasol Propionate, is also available under other brand names including Ultravate (cream and ointment) and Bryhali (a lower-concentration lotion). However, Lexette is the only foam formulation at the 0.05% strength.

Lexette is not a controlled substance. It requires a prescription but does not have DEA scheduling restrictions.

Generic Halobetasol Propionate is available in cream and ointment forms, and an authorized generic of Lexette foam has also become available, making it potentially more accessible and affordable than the brand-name product.

What Is Lexette Used For?

Lexette is FDA-approved for the topical treatment of plaque psoriasis in patients 12 years of age and older. Plaque psoriasis is the most common form of psoriasis, characterized by raised, red patches of skin covered with silvery-white scales. These patches (called plaques) can appear anywhere on the body but most commonly affect the scalp, elbows, knees, and lower back.

Doctors sometimes prescribe Halobetasol Propionate off-label for other inflammatory skin conditions, including:

• Atopic dermatitis (eczema)
• Contact dermatitis
• Seborrheic dermatitis
• Lichen planus

However, because of its super-high potency, Lexette is generally reserved for cases where lower-potency steroids haven't worked. For more about how the medication works, see How Does Lexette Work? Mechanism of Action Explained.

How Is Lexette Taken?

Lexette comes as a topical foam in 50g cans (also available as a 100g package of two 50g cans). Here's how to use it:

1. Shake the can before each use.
2. Dispense a small amount of foam into the palm of your hand.
3. Apply a thin layer to the affected skin areas.
4. Rub in gently and completely.
5. Wash your hands before and after application (unless treating the hands).

Dosage Details

• Frequency: Twice daily (morning and evening)
• Duration: Up to 2 weeks maximum
• Weekly limit: Do not exceed 50 grams per week

Important Application Rules

• Do NOT apply to the face, groin, or underarms
• Do NOT cover with bandages or dressings unless directed by your doctor
• The foam is flammable — avoid heat, flame, or smoking during and immediately after application
• Do NOT use on broken or infected skin unless directed by your doctor

Who Should Not Take Lexette?

While there are no absolute contraindications listed in the prescribing information, Lexette should be used with caution in certain situations:

• Children under 12: Lexette is not approved for use in children under 12 years old.
• Pregnant or breastfeeding women: Use of potent topical steroids exceeding 300g during pregnancy has been associated with low birth weight. Do not apply to breasts while nursing.
• Patients already using other corticosteroids: Using Lexette alongside other topical or oral steroids can increase the risk of HPA axis suppression and other side effects.
• Skin folds or exuding lesions: Lexette should not be applied to these areas.

Always tell your doctor about all medications you're taking. See Lexette Drug Interactions for details.

How Much Does Lexette Cost?

Lexette is an expensive medication:

• Brand-name Lexette: $928 to $1,000 for a 50g can without insurance
• Generic Halobetasol Propionate (cream/ointment): As low as $25 with a coupon through GoodRx
• Authorized generic Lexette foam: May be available at a lower cost than brand-name

Ways to Save

• Mayne Pharma Patient Savings Card: Eligible commercially insured patients may pay $0 copay. Enroll at lexette.com/savings or call 347-442-7919. Not valid for government insurance (Medicare, Medicaid, Tricare).
• Discount coupons: GoodRx, SingleCare, and other coupon platforms can reduce the cost significantly, especially for generic Halobetasol Propionate.
• Patient assistance programs: If you're uninsured or underinsured, organizations like NeedyMeds and RxAssist may be able to help.
• Insurance: Many plans cover generic Halobetasol Propionate. Brand Lexette may require prior authorization and is often on higher formulary tiers.

For a detailed guide on reducing your Lexette costs, see How to Save Money on Lexette.

Final Thoughts

Lexette is a powerful treatment option for plaque psoriasis when lower-potency steroids haven't done the job. It's effective, but it requires careful use — no more than 2 weeks at a time, and no more than 50 grams per week. Its foam formulation makes it easy to apply and absorbs quickly into the skin.

The biggest challenges with Lexette are cost and availability. At nearly $1,000 per can for the brand name, it's out of reach for many patients without insurance or savings programs. But with manufacturer savings cards, generic alternatives, and discount coupons, most patients can find a way to afford their treatment.

If you need help finding Lexette at a pharmacy near you, Medfinder can help you check stock and find it faster.