Comprehensive medication guide to K-Phos Neutral including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$10–$50 copay on most commercial plans (Tier 2–3); Medicare Part D coverage is inconsistent and many plans do not include it on formulary.
Estimated Cash Pricing
$60–$90 retail for brand K-Phos Neutral; as low as $22–$27 for generic Phospha 250 Neutral with GoodRx or SingleCare coupons for a 30-day supply.
Medfinder Findability Score
55/100
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K-Phos Neutral is a prescription phosphate supplement manufactured by Beach Products, Inc. (Tampa, FL). Each film-coated tablet contains 852 mg dibasic sodium phosphate, 155 mg monobasic potassium phosphate, and 130 mg monobasic sodium phosphate — yielding 250 mg of elemental phosphorus (8 mmol), 298 mg of sodium (13.0 mEq), and 45 mg of potassium (1.1 mEq) per tablet.
K-Phos Neutral is used to treat hypophosphatemia (low phosphate levels in the blood) and to prevent calcium kidney stones through urinary acidification. It has been prescribed clinically for more than 30 years. Generic equivalents include Phospha 250 Neutral (Rising Pharmaceuticals) and Phospho-Trin 250 Neutral (Patrin Pharma).
Common conditions for which K-Phos Neutral is prescribed include hypophosphatemia due to malnutrition, alcoholism, refeeding syndrome, or inherited disorders like X-linked hypophosphatemia (XLH); recurrent calcium kidney stones; and urinary acidification to enhance antibiotic effectiveness for urinary tract infections.
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K-Phos Neutral has a dual mechanism of action. First, it directly supplements phosphorus by delivering elemental phosphate that is absorbed in the small intestine (approximately two-thirds of ingested phosphate is absorbed in healthy adults), raising serum phosphate levels. Phosphorus is essential for bone formation, ATP energy production, DNA structure, and cellular signaling.
Second, phosphate that is excreted in the urine increases urinary phosphate and pyrophosphate levels, acidifies the urine, and lowers urinary calcium. These changes create an environment where calcium oxalate and calcium phosphate crystals are less likely to form, reducing the risk of recurrent calcium kidney stones.
Absorption is significantly reduced when K-Phos Neutral is taken with antacids containing calcium, aluminum, or magnesium, or with dairy products, iron, or zinc supplements. The medication should be taken 2-3 hours apart from these products. Each tablet must be taken with a full 8 oz glass of water, with meals and at bedtime.
250 mg phosphorus per tablet — tablet
Film-coated oral tablet providing 250 mg elemental phosphorus, 298 mg sodium, and 45 mg potassium per tablet
1-2 tablets, 4x daily (adults) — tablet
Adult dose: 1-2 tablets four times daily with meals and at bedtime with full glass of water
1 tablet, 4x daily (pediatric >4 years) — tablet
Pediatric dose (over 4 years): 1 tablet four times daily with meals and at bedtime
K-Phos Neutral is not in an active FDA-declared shortage as of 2026. However, it is a low-volume specialty medication that many large chain pharmacies do not routinely stock. Patients frequently need to call multiple pharmacies or ask specifically for generic equivalents (Phospha 250 Neutral, Phospho-Trin 250 Neutral) to fill their prescription. Independent pharmacies and mail-order pharmacies are generally more likely to carry it.
K-Phos Neutral receives a findability score of 55/100 — reflecting intermittent local stocking gaps rather than a national supply crisis. The medication is available from distributors and can typically be ordered by any pharmacy within 1-3 business days. Patients should plan refills 7-10 days in advance to avoid gaps in therapy.
To find which pharmacy near you has K-Phos Neutral in stock, use medfinder — a service that calls pharmacies in your area and texts you the results, saving you the time and frustration of calling pharmacies yourself.
K-Phos Neutral is not a controlled substance and can be prescribed by any licensed prescriber in the United States. It does not require DEA scheduling, special certification, or Risk Evaluation and Mitigation Strategy (REMS) enrollment. However, the conditions it treats — hypophosphatemia and recurrent calcium kidney stones — often benefit from specialist evaluation.
Providers who most commonly prescribe K-Phos Neutral include:
Nephrologists — for hypophosphatemia in CKD, renal tubular disorders, and recurrent kidney stones
Urologists — for calcium kidney stone prevention and urinary acidification
Endocrinologists — for metabolic bone disease, hyperparathyroidism, X-linked hypophosphatemia (XLH)
Primary care physicians (PCPs), internists, nurse practitioners, and physician assistants — for follow-up management
Pediatricians and pediatric specialists — for children over 4 years with hypophosphatemia
Telehealth prescribing is generally permitted for K-Phos Neutral, though most telehealth providers will require supporting lab work (serum phosphate or 24-hour urine) before prescribing. Follow-up management for established patients may be done via telehealth, depending on the platform and clinical situation.
No. K-Phos Neutral is not a controlled substance and has no DEA schedule. It is a prescription medication (not OTC), but it has none of the restrictions associated with controlled substances. Any licensed prescriber — including physicians, nurse practitioners, and physician assistants — can prescribe it. There are no limits on the number of refills, and it can be called in, faxed, or sent electronically.
Patients do not need to physically present a written prescription at the pharmacy — a called-in or electronic prescription is fully acceptable. This makes it easier for patients to receive refills without an in-person office visit, provided their prescriber is comfortable with telephone or portal-based renewals.
The most frequently reported side effects are gastrointestinal and usually improve over time:
Diarrhea (most common; mild laxative effect especially in first days)
Nausea
Stomach pain and abdominal cramps
Vomiting
Dizziness and headache
Muscle cramps
Fast or irregular heartbeat (may indicate hyperkalemia or hyperphosphatemia)
Shortness of breath or difficulty breathing
Swelling of feet or lower legs (sodium-related fluid retention)
Unusual weight gain in a short period
Seizures
Numbness or tingling around the lips (may indicate hypocalcemia)
Bone and joint pain (phosphate-induced osteomalacia with long-term use)
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Phospha 250 Neutral
Generic equivalent by Rising Pharmaceuticals; identical composition to K-Phos Neutral (250 mg phosphorus, 298 mg sodium, 45 mg potassium per tablet). Drop-in substitution.
Phos-NaK
Powder packet alternative providing same 250 mg phosphorus per dose but with more potassium (7.1 mEq) and less sodium (6.9 mEq) than K-Phos Neutral. Mixed in 75 mL water or juice.
Phospho-Trin 250 Neutral
Another brand equivalent with same composition as K-Phos Neutral. May be available at pharmacies that don't carry K-Phos Neutral brand.
K-Phos No. 2
Same manufacturer (Beach Products); higher potassium content (2.3 mEq) than K-Phos Neutral. Primarily for urinary acidification. Requires new prescription.
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Antacids (aluminum, calcium, or magnesium-containing)
majorBind phosphate in the GI tract, preventing absorption and making K-Phos Neutral ineffective. Separate by at least 2-3 hours.
Potassium-sparing diuretics (amiloride, spironolactone, triamterene)
majorConcurrent use increases risk of hyperkalemia. Serum potassium must be monitored closely.
Digoxin
moderateElectrolyte changes from K-Phos Neutral can affect digoxin efficacy and toxicity risk. Regular electrolyte monitoring required.
Calcium / Vitamin D supplements
moderateMay antagonize K-Phos Neutral effects in hypercalcemia treatment; calcium binds phosphate and reduces absorption.
Antihypertensives (guanethidine, hydralazine, methyldopa)
moderateCombined use with sodium phosphate may increase risk of hypernatremia.
Corticosteroids / mineralocorticoids
moderatePromote sodium retention; combined with K-Phos Neutral may increase risk of fluid retention and hypernatremia.
Iron and zinc supplements
minorBind phosphate in the gut, reducing absorption. Separate by 2-3 hours.
Quinapril (ACE inhibitor)
minorMagnesium-containing excipient in quinapril tablets may reduce phosphate absorption. Separate by 2 hours.
K-Phos Neutral is an important but niche medication with a 30-year clinical track record for treating hypophosphatemia and preventing calcium kidney stones. It is safe and effective when taken as directed, but it requires attention to proper administration (always with food and water, always separated from antacids), regular electrolyte monitoring, and awareness of drug interactions — especially with potassium-sparing diuretics.
The biggest practical challenge patients face is finding it at their local pharmacy. K-Phos Neutral is not in a national shortage, but its low dispensing volume means many pharmacies simply don't stock it proactively. Patients can address this by asking for generic equivalents (Phospha 250 Neutral), requesting advance orders at their pharmacy, or using mail-order. With GoodRx, the cost can be as low as $22-$27 for a 30-day supply at standard dosing.
If you're struggling to find K-Phos Neutral at a pharmacy near you, medfinder can help. The service calls pharmacies near you to find which ones can fill your prescription and texts you the results — no hold music, no repeated phone calls.
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Real-time availability
Verified 50m ago
Based on 31 real pharmacy checks · 1 patients helped
K-Phos Neutral is in a shortage right now — Medfinder calls pharmacies near you to track down the ones that have it.
As of July 23, 2026, 2:01 PM ET, K-phos Neutral is currently experiencing a shortage. Across 31 pharmacy checks Medfinder placed in the last 30 days, K-phos Neutral was confirmed in stock 3% of the time.
K-phos Neutral is not on the FDA's active shortage list. Medfinder's own pharmacy calls put real-time availability at 3% across 31 checks in the last 30 days. Availability varies by metro, with the most pharmacy activity recorded around Seattle, WA. These numbers are recomputed continuously from live pharmacy calls, so this page reflects current conditions rather than a static estimate.
Is K-phos Neutral in stock right now?
As of July 23, 2026, 2:01 PM ET, K-phos Neutral was confirmed in stock at 3% of 31 pharmacies Medfinder checked in the last 30 days. Availability changes daily, so we re-check in real time when you search.
How does Medfinder help me find K-phos Neutral?
Medfinder calls pharmacies in your area to verify whether K-phos Neutral and your specific dose are in stock, then sends you the pharmacy name, address, and phone number.
Need K-Phos Neutral? We'll find the pharmacy that has it.
Sources: FDA Drug Shortages + Medfinder pharmacy data · Methodology · Full K-Phos Neutral data
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