What Is K-Phos Neutral? Uses, Dosage, and What You Need to Know in 2026

K-Phos Neutral is a prescription phosphate supplement containing potassium and sodium phosphate. It's been used clinically for more than 30 years to treat low phosphate levels in the blood (hypophosphatemia) and to help prevent certain types of kidney stones. If you've been prescribed K-Phos Neutral or are considering asking your doctor about it, this guide covers everything you need to know.

What Is K-Phos Neutral?

K-Phos Neutral is the brand name for a combination phosphate supplement manufactured by Beach Products, Inc. (Tampa, FL). Each white, film-coated tablet contains:

852 mg dibasic sodium phosphate, anhydrous

155 mg monobasic potassium phosphate

130 mg monobasic sodium phosphate monohydrate

Each tablet yields approximately

250 mg (8 mmol) of elemental phosphorus — providing 25% of the US recommended daily allowance (RDA) for adults

298 mg (13.0 mEq) of sodium

45 mg (1.1 mEq) of potassium

What Is K-Phos Neutral Used For?

K-Phos Neutral has two primary uses:

Phosphate supplementation: To treat hypophosphatemia (low blood phosphate levels). Phosphorus is essential for bone health, energy metabolism, and proper cell function. Low levels can result from poor nutrition, alcoholism, certain medications (antacids, some diuretics), hyperparathyroidism, refeeding syndrome, and inherited conditions like X-linked hypophosphatemia (XLH).

Urinary acidification and kidney stone prevention: K-Phos Neutral increases phosphate and pyrophosphate in urine, which acidifies the urine and lowers urinary calcium. This makes it harder for calcium oxalate and calcium phosphate kidney stones to form, and helps prevent recurrence.

Is K-Phos Neutral a Controlled Substance?

No. K-Phos Neutral is not a controlled substance and has no DEA schedule. It can be prescribed by any licensed prescriber and can be called in by phone, faxed, or sent electronically. There are no restrictions on the number of refills.

Dosage and How to Take K-Phos Neutral

Standard dosing per the prescribing information:

Adults: 1 to 2 tablets four times daily (with meals and at bedtime)

Children over 4 years: 1 tablet four times daily

Children under 4: Use only as directed by a physician

Always take with a full 8 oz (240 mL) glass of water. Take with meals and at bedtime to reduce gastrointestinal side effects. Do not take with antacids containing aluminum, calcium, or magnesium — separate them by at least 2-3 hours.

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Who Should NOT Take K-Phos Neutral?

K-Phos Neutral is contraindicated in:

Patients with infected phosphate stones

Patients with severe renal impairment (kidney function less than 30% of normal)

Patients with hyperphosphatemia (too much phosphorus in the blood)

Use with caution in patients with cardiac disease, edema, hypertension, renal disease, cirrhosis, hypoparathyroidism, or severe burns. The sodium content (298 mg per tablet) should be considered in patients on sodium-restricted diets.

Generic Names and Equivalent Products

K-Phos Neutral is available under several names:

Brand: K-Phos Neutral (Beach Products)

Generic equivalents: Phospha 250 Neutral (Rising Pharmaceuticals), Phospho-Trin 250 Neutral (Patrin Pharma)

Generic drug name: potassium phosphate / sodium phosphate

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How to Fill Your K-Phos Neutral Prescription

K-Phos Neutral can be tricky to find at some pharmacies. If you're having difficulty locating it near you, see our guide on how to find K-Phos Neutral in stock, or use medfinder to find a pharmacy near you that can fill your prescription.