Comprehensive medication guide to Isibloom 28 Day including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0 copay for most patients with ACA-compliant insurance under the contraceptive mandate; Tier 1 on most formularies when Isibloom or an equivalent desogestrel/EE generic is covered; prior authorization generally not required for standard contraceptive use.
Estimated Cash Pricing
Average retail price is approximately $56.98 for a 28-tablet pack without insurance; with GoodRx, prices start around $19–$24 per pack, and SingleCare can bring the cost as low as $11.99 per pack at participating pharmacies.
Medfinder Findability Score
65/100
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Isibloom 28 Day is a prescription monophasic combination oral contraceptive (COC) containing desogestrel (0.15 mg) and ethinyl estradiol (0.03 mg) per active tablet. It is a generic medication manufactured by Xiromed and is the therapeutic equivalent of the discontinued brand-name drug Desogen (originally Ortho-Cept).
Each 28-day pack contains 21 active orange tablets and 7 inert green tablets. The active tablets contain the contraceptive hormones; the green tablets are placebo pills taken during the period week to maintain the daily pill-taking habit. Isibloom is not a controlled substance and does not require DEA scheduling.
FDA-approved for the prevention of pregnancy, Isibloom is also prescribed off-label for acne management, PMS/PMDD, menstrual cycle regulation, endometriosis symptom management, and PCOS hormone management.
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Isibloom prevents pregnancy through three complementary mechanisms. The primary mechanism is ovulation suppression: the synthetic hormones (desogestrel and ethinyl estradiol) signal the hypothalamus and pituitary gland to suppress the LH surge that triggers egg release. Without ovulation, there is no egg to fertilize.
Desogestrel (converted to its active form etonogestrel in the body) also thickens cervical mucus, creating a physical barrier that prevents sperm from reaching the uterus. Simultaneously, both hormones thin the uterine lining (endometrium), making it less receptive to implantation. The combined effect of these three mechanisms provides highly effective contraception — greater than 99% with perfect use.
Because Isibloom is monophasic — meaning every active tablet delivers the same hormone dose — blood levels of desogestrel and ethinyl estradiol remain consistent throughout the 21-day active period. Consistent daily dosing at the same time each day is critical for maintaining adequate hormone levels to suppress ovulation.
0.15 mg desogestrel / 0.03 mg ethinyl estradiol — tablet (oral)
21 active orange tablets + 7 inert green tablets per 28-day pack. Take 1 tablet daily for 28 days continuously, then immediately start a new pack.
As of 2026, Isibloom 28 Day is not listed on the FDA's Drug Shortage Database — there is no national supply crisis for this medication. However, patients regularly encounter localized stock gaps at individual pharmacies. Isibloom competes in a crowded branded generic space with more than a dozen products containing the same desogestrel/ethinyl estradiol formula. Not every pharmacy stocks every version.
Stock gaps are driven by formulary changes (when insurance plans shift their preferred generic, demand spikes for the newly-preferred product), distributor allocation, and the general unpredictability of the generic drug supply chain. When Isibloom is unavailable at one pharmacy, it is almost always available nearby — the challenge is finding which pharmacy.
That's exactly what medfinder solves. medfinder contacts pharmacies near you to identify which ones can fill your Isibloom prescription, then texts you the results — so you don't waste time calling around.
Isibloom 28 Day is not a controlled substance, so it can be prescribed by a wide range of licensed healthcare providers without special DEA registration. Prescribers do not need any special certification to write a prescription for Isibloom — any licensed provider authorized to prescribe non-controlled medications can do so.
The following types of providers commonly prescribe Isibloom:
Telehealth providers also prescribe Isibloom widely. Services such as Nurx, Pandia Health, SimpleHealth, and The Pill Club offer online consultations and can prescribe Isibloom or an equivalent, delivering directly to the patient's home. In several states, pharmacists are now also authorized to prescribe hormonal contraceptives directly — check your state's pharmacy board for current rules.
No. Isibloom 28 Day (desogestrel/ethinyl estradiol) is not a controlled substance and is not scheduled by the DEA. It does not require special DEA registration for prescribers, has no restrictions on the number of refills, and can be phoned in or electronically transmitted by office staff.
Prescriptions for Isibloom can be freely transferred between pharmacies. Most prescribers write a 12-month supply (12 packs) at a time. Patients can request 90-day fills at mail-order pharmacies. Because Isibloom is not a controlled substance, many states also allow pharmacists to prescribe it directly — check your state's pharmacy board for current rules.
Most side effects are mild and resolve within 2–3 months as the body adjusts to the hormones:
Serious side effects — seek emergency care immediately:
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Apri 28 Day
Direct equivalent — same desogestrel/EE formula (0.15 mg/0.03 mg); AB-rated; widely stocked at major chains.
Enskyce 28 Day
Direct equivalent — same formula as Isibloom; another branded generic option when Isibloom is unavailable.
Sprintec (norgestimate/EE)
Same drug class (combination OCP) with norgestimate progestin instead of desogestrel; widely available and stocked.
Junel Fe (norethindrone/EE)
Combination OCP with norethindrone progestin and iron supplement in placebo pills; good for patients tolerating lower estrogen dose.
Prefer Isibloom 28 Day? We can find it.
Carbamazepine (Tegretol)
majorCYP3A4 inducer that significantly reduces desogestrel and ethinyl estradiol plasma levels, potentially reducing contraceptive effectiveness. Use backup contraception during use and for 28 days after stopping.
Rifampin
majorPotent CYP3A4 inducer; dramatically reduces COC hormone levels. Do not rely on Isibloom alone for contraception during rifampin therapy.
Viekira Pak (dasabuvir/ombitasvir/paritaprevir/ritonavir)
majorContraindicated with ethinyl estradiol-containing COCs — can cause significant ALT elevations. Must stop Isibloom before starting Viekira Pak and not restart until 2 weeks after completing treatment.
Lamotrigine (Lamictal)
majorIsibloom significantly reduces lamotrigine plasma levels (by ~40-50%) through glucuronidation induction. May require lamotrigine dose adjustment. Starting or stopping Isibloom can destabilize seizure or mood control.
St. John's Wort
majorHerbal CYP3A4 inducer that can reduce contraceptive hormone levels and increase risk of contraceptive failure. Use backup contraception if taking St. John's Wort.
Phenytoin (Dilantin)
majorCYP3A4 inducer; reduces contraceptive efficacy. Use backup contraception during use and for 28 days after stopping.
Topiramate (Topamax)
moderateAt doses ≥200 mg/day, may reduce EE exposure by up to 30%; consider backup contraception or alternative method.
Thyroid hormone replacement (levothyroxine)
moderateIsibloom increases thyroid-binding globulin; may require increased thyroid hormone dose. Monitor TSH after starting or stopping Isibloom.
Isibloom 28 Day is a safe, effective, and affordable combination oral contraceptive with a well-established track record. As a generic medication, it is accessible through insurance coverage, discount programs, and community health resources — most patients with ACA-compliant insurance pay $0 out of pocket. For those without insurance, SingleCare and GoodRx bring the cost to as little as $12 per pack.
The main challenge Isibloom users face is localized pharmacy stock gaps — not a national shortage, but the frustrating reality that not every pharmacy carries every branded generic. Planning ahead, using 90-day supplies, and knowing your equivalent substitutes (Apri, Enskyce, Reclipsen) makes it much easier to stay on schedule.
If you ever find your pharmacy is out of Isibloom, medfinder can quickly identify which pharmacies near you have it in stock — so you never have to miss a dose.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
Real-time availability
Medfinder is actively checking pharmacy inventory for Isibloom 28 Day. We don't publish a number until we have enough verified pharmacy checks to be accurate — start a search and our team confirms current availability near you, usually within 24 hours.
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