Comprehensive medication guide to Apri 28 Day including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0–$0/month
Estimated Cash Pricing
$10–$99/month
Medfinder Findability Score
65/100
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Apri 28 Day is a combined oral contraceptive (birth control pill) that contains two synthetic hormones: desogestrel (a progestin) and ethinyl estradiol (an estrogen). It is FDA-approved for the prevention of pregnancy.
Apri is also commonly prescribed off-label for managing acne, regulating irregular menstrual cycles, reducing menstrual cramps (dysmenorrhea), and helping with symptoms of endometriosis and polycystic ovary syndrome (PCOS).
Each 28-day pack includes 21 active hormone tablets and 7 placebo tablets. You take one pill daily at the same time and start a new pack immediately after finishing the current one.
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Apri 28 Day Pack
21 active rose-colored tablets (desogestrel 0.15 mg / ethinyl estradiol 0.03 mg) plus 7 white inactive (placebo) tablets
Serious side effects are rare but may include blood clots (deep vein thrombosis, pulmonary embolism), stroke, heart attack, liver problems, and gallbladder disease. Seek immediate medical attention if you experience severe leg pain, chest pain, sudden shortness of breath, severe headache, or vision changes.
⚠️ Boxed Warning: Cigarette smoking increases the risk of serious cardiovascular side effects from oral contraceptive use. This risk increases with age and heavy smoking (15+ cigarettes/day) and is especially significant in women over 35. Women using Apri should not smoke.
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Reclipsen
Same active ingredients (desogestrel 0.15 mg / ethinyl estradiol 0.03 mg), different manufacturer. A direct equivalent to Apri.
Enskyce
Another branded generic with an identical formulation to Apri.
Emoquette, Solia, Isibloom, Juleber, Cyred
Additional branded generics with the same desogestrel/ethinyl estradiol formulation.
Desogen / Ortho-Cept
Brand-name versions of the same active ingredients.
Sprintec
Uses a different progestin (norgestimate 0.25 mg / ethinyl estradiol 0.035 mg); one of the most commonly prescribed oral contraceptives in the U.S.
Junel FE 1.5/30
Contains norethindrone acetate 1.5 mg / ethinyl estradiol 0.03 mg plus iron; another popular monophasic oral contraceptive.
Prefer Apri 28 Day? We can find it.
Anticonvulsants
moderatePhenytoin, carbamazepine, phenobarbital, topiramate, felbamate, and oxcarbazepine can decrease hormone levels.
Rifampin / Rifabutin
moderateSignificantly reduce contraceptive effectiveness; use an alternative or backup method.
St. John's Wort
moderateThis herbal supplement reduces oral contraceptive effectiveness and should be avoided.
HIV protease inhibitors and NNRTIs
moderateMay alter hormone levels; consult your prescriber.
Hepatitis C antivirals
moderate(ombitasvir/paritaprevir/ritonavir) — Risk of elevated liver enzymes (ALT); contraindicated with Apri.
Barbiturates and Griseofulvin
moderateMay reduce contraceptive effectiveness.
Lamotrigine
moderateOral contraceptives may decrease Lamotrigine levels, potentially affecting seizure control. Dose adjustments may be needed.
Grapefruit juice
moderateMay increase estrogen levels; consume in moderation.
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