Comprehensive medication guide to Integra F including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0–$20 copay if covered; most commercial plans and Medicare do not cover Integra F because its active ingredients are available OTC. Use a discount card for most reliable savings.
Estimated Cash Pricing
$29–$30 retail for a 30-day supply; as low as $14.05 with GoodRx Gold or $19.16 with SingleCare at participating pharmacies. No generic version is available.
Medfinder Findability Score
60/100
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Integra F is a brand-name prescription supplement manufactured by U.S. Pharmaceutical Corporation. Each capsule contains 125 mg of elemental iron (from Ferrous Fumarate and Polysaccharide Iron Complex), 1 mg of folic acid, 40 mg of Vitamin C, and 3 mg of Vitamin B3 (niacin). It is dispensed as maroon Vcaps capsules and is available by prescription only.
Integra F is indicated for the treatment of iron deficiency anemia and folate deficiency anemia. It is also specifically indicated in pregnancy for the prevention and treatment of iron deficiency and to maintain therapeutic folic acid levels. Integra F is not a controlled substance and has no DEA scheduling.
Integra F is classified as a prescription supplement (also sometimes called a marketed unapproved drug), meaning it requires a prescription but its labeling has not been formally approved by the FDA as a drug. This regulatory status affects its insurance coverage and pharmacy stocking — it is not listed in the FDA shortage database and many insurers decline to cover it.
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Integra F uses a patented dual-iron formula to deliver 125 mg of elemental iron through two different mechanisms. Ferrous Fumarate provides 62.5 mg of ferrous (Fe2+) iron — highly bioavailable and well-absorbed in the duodenum. Polysaccharide Iron Complex provides the other 62.5 mg as ferric iron complexed to a polysaccharide, absorbed through a gentler, acid-independent pathway.
By distributing iron delivery across two pathways, the formula reduces localized GI iron irritation — which is the main reason ferrous sulfate causes constipation and nausea. Research cited in the prescribing literature found the combination was better tolerated than ferrous fumarate alone.
Folic acid (1 mg) supports red blood cell production by enabling DNA synthesis in developing blood cells. Vitamin C (40 mg) enhances iron bioavailability by reducing ferric iron to the more absorbable ferrous form in the GI tract. Once absorbed, iron is transported to the bone marrow where it is incorporated into hemoglobin in new red blood cells.
125 mg iron / 1 mg folic acid — capsule
One capsule daily between meals. Contains 125 mg elemental iron from dual sources plus 1 mg folic acid, 40 mg Vitamin C, 3 mg Niacin.
Integra F is not on the FDA official drug shortage list, but finding it at a pharmacy can take real effort. As a brand-name-only prescription supplement with no generic, limited insurance coverage, and a single manufacturer, many retail pharmacies simply don't stock it regularly. Patients may need to check multiple pharmacies before finding it in stock.
Independent pharmacies and specialty pharmacies are sometimes better stocked than chain pharmacies. Mail-order pharmacies can be a reliable source for a 90-day supply. Most pharmacies can special-order Integra F with 1–3 business days lead time if it's not on their shelf.
The fastest way to find a pharmacy with Integra F in stock is to use medfinder — a service that calls pharmacies near you to check stock and texts you results, so you don't spend your time on hold.
Integra F is not a controlled substance and has no DEA scheduling requirements. Any licensed prescriber with prescribing authority can write a prescription. No special DEA registration or REMS program enrollment is required.
Integra F can also be prescribed via telehealth in states that allow telehealth prescribing for non-controlled medications. Telehealth services like Teladoc and MDLive can evaluate iron deficiency based on recent lab results and issue an Integra F prescription without an in-person visit.
No. Integra F is not a DEA-scheduled controlled substance. It does not appear on any DEA schedule (I through V). While it is labeled as "Rx only" and requires a valid prescription, it has none of the special prescribing, dispensing, or refill restrictions that apply to controlled substances.
Any licensed prescriber with prescribing authority — including nurse practitioners and physician assistants in most states — can prescribe Integra F without special DEA registration. It can also be prescribed via telehealth in states that allow non-controlled prescriptions via telehealth. Pharmacies can refill it without the limitations that apply to Schedule II through V medications.
Integra F is generally well-tolerated compared to standard ferrous sulfate due to its dual-iron formula. Common side effects include:
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Ferrous Sulfate + Folic Acid (generic)
Most affordable alternative (~$2–$8/month). Provides ~65 mg elemental iron with 1 mg folic acid. Higher incidence of GI side effects than Integra F.
Ferralet 90
Prescription supplement with 90 mg carbonyl iron, 1 mg folic acid, B12, and docusate sodium stool softener. Often prescribed for obstetric patients. Well-tolerated.
Integra Plus
Same dual-iron formula as Integra F (125 mg elemental iron) plus comprehensive B-vitamin complex. Made by same manufacturer. Best choice when B-vitamins are also needed.
Niferex (Polysaccharide Iron Complex)
Provides iron as polysaccharide complex only — one of the two iron forms in Integra F. Very low GI side effect profile. Some versions include folic acid.
Prefer Integra F? We can find it.
Tetracycline antibiotics (doxycycline, minocycline)
majorIron significantly reduces tetracycline absorption by 40–90%. Separate doses by at least 2 hours.
Fluoroquinolones (ciprofloxacin, levofloxacin)
majorIron chelates fluoroquinolones in the gut, reducing their bioavailability. Separate doses by at least 2 hours.
Levothyroxine (Synthroid)
majorIron significantly reduces levothyroxine absorption. Separate by at least 4 hours. Take thyroid medication in the morning and Integra F later in the day.
Antacids / Proton Pump Inhibitors
moderateReduce stomach acid and iron absorption. Separate by at least 2 hours.
Calcium supplements / dairy
moderateCalcium competes with iron for intestinal absorption. Take 2+ hours apart.
Levodopa / carbidopa (Sinemet)
moderateIron reduces levodopa absorption, potentially affecting Parkinson's treatment efficacy.
Alcohol
minorCombined with the niacin component, alcohol may cause facial flushing. Excessive use should be avoided.
Integra F is a well-designed prescription iron supplement for patients who need high-dose iron with folic acid and who may have had difficulty tolerating standard ferrous sulfate. Its patented dual-iron formula (Ferrous Fumarate + Polysaccharide Iron Complex) provides 125 mg elemental iron per capsule with lower GI irritation than single-source iron products — a genuine clinical advantage for many patients.
The main practical challenges are availability and cost. Because Integra F is brand-only with no generic, and most insurance plans decline to cover it, patients often pay out of pocket at $15–$30 per month with a discount card. Finding it at a pharmacy requires more effort than filling a standard generic — but it is available if you know where to look.
If you've been prescribed Integra F, start your search with medfinder to find a pharmacy near you that has it in stock. And always use a discount card — GoodRx Gold can reduce the cost to as little as $14 per month.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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