Medications

Enpresse 28 Day

Enpresse 28 Day

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Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.

Estimated Insurance Pricing
Most insurance plans cover Enpresse 28 Day generics with $0 copay under the ACA contraceptive mandate.
Estimated Cash Pricing
Enpresse 28 Day typically costs $29 to $75 per pack without insurance, or as low as $11 to $30 with a discount card.
Medfinder Findability Score
65
/100
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Post Author

Peter Daggett

Last Updated

February 14, 2026

Enpresse 28 Day 2026 Availability, Prices, and Tips to Find

What Is Enpresse 28 Day?

Enpresse 28 Day is a triphasic combination oral contraceptive containing levonorgestrel (a progestin) and ethinyl estradiol (an estrogen). It is FDA-approved for the prevention of pregnancy. The triphasic design means the hormone levels change across three phases during each 28-day cycle, more closely mimicking the body's natural hormonal fluctuations.

In addition to contraception, Enpresse 28 Day is sometimes prescribed off-label for regulating menstrual cycles, reducing menstrual cramps, managing endometriosis symptoms, treating acne, and controlling abnormal uterine bleeding.

How does Enpresse 28 Day work?

Enpresse 28 Day works through three primary mechanisms to prevent pregnancy:

  • Suppresses ovulation: The combination of levonorgestrel and ethinyl estradiol inhibits the release of gonadotropins (FSH and LH) from the pituitary gland, preventing the ovaries from releasing an egg.
  • Thickens cervical mucus: The progestin component makes cervical mucus thicker, creating a barrier that impedes sperm penetration.
  • Alters the endometrial lining: Changes to the uterine lining reduce the likelihood of implantation in the unlikely event that fertilization occurs.

What doses are available for Enpresse 28 Day?

Enpresse 28 Day comes in a single 28-day triphasic pack containing three phases of active tablets plus inert tablets:

  • Phase 1 (6 pink tablets): 0.050 mg levonorgestrel / 0.030 mg ethinyl estradiol
  • Phase 2 (5 white tablets): 0.075 mg levonorgestrel / 0.040 mg ethinyl estradiol
  • Phase 3 (10 orange tablets): 0.125 mg levonorgestrel / 0.030 mg ethinyl estradiol
  • 7 light-green inert (placebo) tablets

How hard is it to find Enpresse 28 Day in stock?

Enpresse 28 Day has a findability score of 65 out of 100, meaning it can be intermittently difficult to locate. The Enpresse brand name has been largely discontinued by Teva Pharmaceuticals after closing its Irvine, California manufacturing plant in 2022. However, generic triphasic levonorgestrel/ethinyl estradiol tablets remain available from multiple manufacturers. If your pharmacy doesn't have Enpresse specifically, ask about generic equivalents like Trivora-28 or other triphasic levonorgestrel/ethinyl estradiol products. Use Medfinder to check real-time availability near you.

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Who Can Prescribe Enpresse 28 Day?

Enpresse 28 Day can be prescribed by a wide range of healthcare providers, including:

  • OB/GYN specialists — most commonly prescribe oral contraceptives
  • Family Medicine physicians
  • Internal Medicine doctors
  • Adolescent Medicine specialists
  • Primary Care providers (including nurse practitioners and physician assistants)

Telehealth services also prescribe Enpresse 28 Day and its generic equivalents, making it convenient to get a prescription without an in-person visit.

Is Enpresse 28 Day a controlled substance?

No, Enpresse 28 Day is not a controlled substance. It has no DEA scheduling and does not carry any restrictions related to controlled substance regulations. It requires a prescription but can be obtained at any pharmacy without special dispensing requirements.

Common Side Effects of Enpresse 28 Day

Like all combination oral contraceptives, Enpresse 28 Day may cause side effects. Common side effects include:

  • Nausea
  • Vomiting
  • Breakthrough bleeding or spotting
  • Weight gain
  • Breast tenderness
  • Headache
  • Mood changes
  • Bloating
  • Changes in appetite
  • Difficulty wearing contact lenses

Serious side effects are rare but include blood clots, stroke, heart attack, liver tumors, and gallbladder disease. Seek immediate medical attention if you experience sudden severe headache, chest pain, leg swelling, or vision changes.

Boxed Warning: Cigarette smoking increases the risk of serious cardiovascular side effects, especially in women over 35 who smoke 15 or more cigarettes per day.

Alternative Medications to Enpresse 28 Day

If you cannot find Enpresse 28 Day in stock, several alternatives contain the same or similar active ingredients:

  • Trivora-28: Same triphasic levonorgestrel/ethinyl estradiol formulation from a different manufacturer
  • Levlen 28: Monophasic levonorgestrel/ethinyl estradiol combination oral contraceptive
  • Tri-Sprintec: Triphasic oral contraceptive with norgestimate/ethinyl estradiol
  • Ortho Tri-Cyclen: Triphasic oral contraceptive with norgestimate/ethinyl estradiol, also FDA-approved for acne

Talk to your prescriber about switching if Enpresse 28 Day is unavailable. Use Medfinder to compare availability of these alternatives near you.

Drug Interactions with Enpresse 28 Day

Several medications can reduce the effectiveness of Enpresse 28 Day or cause dangerous interactions:

  • Rifampin: Significantly reduces contraceptive effectiveness
  • Anticonvulsants: Phenytoin, carbamazepine, phenobarbital, topiramate, felbamate, oxcarbazepine
  • HIV medications: Ritonavir, nelfinavir, efavirenz
  • St. John's Wort: Herbal supplement that reduces contraceptive effectiveness
  • Bosentan: Used for pulmonary arterial hypertension
  • Lamotrigine: Oral contraceptives may reduce lamotrigine levels, affecting seizure control
  • Certain antibiotics: Ampicillin, tetracycline (use backup contraception as a precaution)

Always inform your doctor and pharmacist about all medications and supplements you are taking.

Final Thoughts on Enpresse 28 Day

Enpresse 28 Day is an effective triphasic oral contraceptive, but the brand name has been largely discontinued. Generic equivalents containing the same triphasic levonorgestrel/ethinyl estradiol formulation are widely available and typically covered at no cost under insurance. If you're having trouble finding Enpresse 28 Day specifically, ask your pharmacist about Trivora-28 or other generic triphasic levonorgestrel/ethinyl estradiol products. Use Medfinder to check real-time stock at pharmacies near you and save time.

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