Enpresse 28 Day: A Complete Overview

Enpresse 28 Day is a triphasic combination oral contraceptive that contains Levonorgestrel (a progestin) and Ethinyl Estradiol (an estrogen), used to prevent pregnancy.

Whether your doctor just prescribed it, you're researching your options, or you're trying to understand what's in your pill pack, this guide covers everything you need to know about Enpresse 28 Day in 2026 — from how it works to how much it costs.

What Is Enpresse 28 Day?

Enpresse 28 Day is a brand-name prescription birth control pill manufactured by Teva Pharmaceuticals USA. It belongs to the drug class of combination oral contraceptives, meaning it contains both an estrogen and a progestin.

What makes Enpresse different from many birth control pills is that it's triphasic — the hormone doses change three times during each 28-day cycle:

• Phase 1 (Days 1–6): 6 pink tablets — 0.050 mg Levonorgestrel / 0.030 mg Ethinyl Estradiol
• Phase 2 (Days 7–11): 5 white tablets — 0.075 mg Levonorgestrel / 0.040 mg Ethinyl Estradiol
• Phase 3 (Days 12–21): 10 orange tablets — 0.125 mg Levonorgestrel / 0.030 mg Ethinyl Estradiol
• Days 22–28: 7 light-green inert (inactive) tablets — no hormones

The generic name is Levonorgestrel and Ethinyl Estradiol (triphasic regimen). Other brand names for the same formulation include Triphasil, Trivora, and Tri-Levlen. Enpresse is not a controlled substance and does not require a DEA schedule.

Important note: The Enpresse brand has been largely discontinued by Teva Pharmaceuticals. Generic equivalents are widely available and contain the identical active ingredients.

What Is Enpresse 28 Day Used For?

Enpresse 28 Day is FDA-approved for one indication:

• Prevention of pregnancy (oral contraception)

However, doctors also prescribe it off-label for several other purposes:

• Regulation of irregular menstrual cycles
• Treatment of acne
• Reduction of menstrual cramps (dysmenorrhea)
• Management of endometriosis symptoms
• Treatment of abnormal uterine bleeding

For a detailed explanation of how the drug prevents pregnancy, see our article on how Enpresse 28 Day works.

How Is Enpresse 28 Day Taken?

Take one tablet daily at the same time each day for 28 consecutive days. Here's how to use it:

1. Start on Day 1 of your menstrual period, or on the first Sunday after your period begins (as directed by your doctor).
2. Take the tablets in order as marked on the dispenser — pink tablets first, then white, then orange, then light-green.
3. Take it at the same time every day to maximize effectiveness and reduce spotting.
4. Start a new pack the next day after finishing the 28-day pack. There is no gap between packs.

The light-green tablets in the last week contain no active ingredients. They're included to help you stay in the habit of taking a pill every day. Your period should arrive during this week.

If you miss a pill, refer to the patient information that comes with your pack or call your doctor. Missing pills can reduce effectiveness and increase the risk of breakthrough bleeding.

Who Should Not Take Enpresse 28 Day?

Enpresse 28 Day is not safe for everyone. You should not take it if you have any of the following:

• Known or suspected pregnancy
• History of blood clots (deep vein thrombosis or pulmonary embolism)
• History of stroke or heart attack
• Known or suspected breast cancer or estrogen-dependent tumors
• Liver tumors or active liver disease
• Undiagnosed abnormal vaginal bleeding
• Uncontrolled high blood pressure
• Diabetes with vascular complications
• Migraines with aura (focal neurological symptoms)
• Major surgery with prolonged immobilization
• Smoking and age over 35 — this combination significantly increases cardiovascular risk

For a full list of potential side effects, read our Enpresse 28 Day side effects guide. For information about medications that may interact with it, see our drug interactions guide.

How Much Does Enpresse 28 Day Cost?

Here's what you can expect to pay:

• Brand-name Enpresse: $29 to $75 per 28-tablet pack without insurance (when available)
• Generic versions: $11 to $30 per pack with a discount card
• With insurance: Most plans cover oral contraceptives with no copay under the ACA contraceptive mandate. Generic versions are typically Tier 1 on formulary.

Since the Enpresse brand is largely discontinued, most patients will receive a generic, which is more affordable. Prior authorization is generally not required for generic oral contraceptives.

If you're paying out of pocket, discount cards from GoodRx, SingleCare, or RxSaver can significantly reduce costs. For uninsured patients, Planned Parenthood clinics and Title X health centers provide contraceptives at low or no cost. See our full savings guide for Enpresse 28 Day.

Final Thoughts

Enpresse 28 Day is a well-established triphasic oral contraceptive that has been used safely for decades. While the brand name has been discontinued, the same formulation lives on in widely available generics like Trivora-28. It's effective, affordable (especially with insurance or discount cards), and prescribed by a wide range of healthcare providers.

If you're looking for a pharmacy that has it in stock, Medfinder can help you find it near you without the hassle of calling around.