Comprehensive medication guide to Dutasteride/Tamsulosin including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$15–$80 copay per month for generic dutasteride/tamsulosin on most commercial plans; typically Tier 2–3 on formulary. Some plans require step therapy (prior use of the individual components). Medicare Part D coverage varies by plan; out-of-pocket cap is $2,100 in 2026.
Estimated Cash Pricing
$451 retail for a 90-capsule supply of generic dutasteride/tamsulosin 0.5 mg/0.4 mg; as low as $99–$109 with GoodRx or SingleCare coupons for a 90-day supply. Brand-name Jalyn costs over $1,900 for 30 capsules — use the generic.
Medfinder Findability Score
72/100
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Dutasteride/tamsulosin, sold under the brand name Jalyn, is an FDA-approved combination capsule for treating benign prostatic hyperplasia (BPH) — the medical term for an enlarged prostate. It was approved by the FDA on June 14, 2010, and is manufactured by GlaxoSmithKline (GSK). The medication brings together two proven BPH treatments in a single once-daily capsule: dutasteride 0.5 mg and tamsulosin hydrochloride 0.4 mg.
BPH is an extremely common condition in aging men — affecting roughly 50% of men over age 50 and more than 90% of men over age 80. An enlarged prostate can squeeze the urethra (the tube that carries urine from the bladder), causing urinary symptoms including weak stream, frequency, urgency, nocturia, and difficulty starting or completely emptying the bladder. Left untreated, severe BPH can lead to acute urinary retention (sudden inability to urinate) or require surgical intervention.
Dutasteride/tamsulosin is not a controlled substance. It is available as a generic (dutasteride/tamsulosin 0.5 mg/0.4 mg capsules) from multiple manufacturers. Generic versions are therapeutically equivalent to brand-name Jalyn and significantly less expensive.
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Dutasteride/tamsulosin works through two distinct and complementary mechanisms, one for each active ingredient. Dutasteride is a 5-alpha reductase inhibitor (5-ARI). It inhibits both type 1 and type 2 isoforms of the enzyme 5-alpha reductase, which converts testosterone into dihydrotestosterone (DHT). DHT is the primary hormone that drives prostate growth. By blocking DHT production, dutasteride removes the growth signal from prostate cells, causing the prostate to gradually shrink in size over several months. This directly addresses the structural cause of urinary obstruction in BPH.
Tamsulosin is a selective alpha-1A adrenergic receptor blocker. The smooth muscle tissue around the prostate, prostate capsule, and bladder neck contains alpha-1A receptors. When tamsulosin blocks these receptors, the surrounding muscle relaxes — widening the urinary passage and reducing resistance to urine flow. This provides faster symptom relief, often noticeable within days to weeks. The two components together address both the structural bulk of the enlarged prostate and the functional muscle tension — which is why the combination consistently outperforms either drug alone in clinical trials.
The landmark CombAT clinical trial (4,844 patients, 4 years) demonstrated that combination therapy reduced the risk of acute urinary retention or BPH-related surgery by 66% compared to tamsulosin alone, and reduced BPH disease progression by 44% versus tamsulosin and 31% versus dutasteride alone. Dutasteride also reduces serum PSA by approximately 50% within 3–6 months — this is expected and must be accounted for in prostate cancer monitoring.
0.5 mg / 0.4 mg — capsule
Dutasteride 0.5 mg + Tamsulosin HCl 0.4 mg; once daily 30 minutes after the same meal; swallow whole, do not chew or crush
As of 2026, dutasteride/tamsulosin is not listed on the FDA's official drug shortage database. Generic versions are produced by multiple manufacturers, providing a broad national supply base. The individual components — generic dutasteride and generic tamsulosin — are among the most widely available medications in the United States. However, the fixed-dose combination capsule is a lower-volume product compared to the individual generics, and not every pharmacy stocks it routinely. Patients often report difficulty at specific pharmacies even when there is no systemic shortage.
If your pharmacy is out of stock, the fastest solution is to use medfinder to find pharmacies near you that have it available. medfinder calls pharmacies on your behalf and texts you results. Alternatively, ask your pharmacist to special-order it (typically a 1–2 business day wait), or ask your prescriber to prescribe dutasteride 0.5 mg and tamsulosin 0.4 mg as separate generics — which are universally stocked and often less expensive when discount coupons are applied separately.
Dutasteride/tamsulosin is not a controlled substance and has no DEA scheduling restrictions. Any licensed prescriber with prescribing authority can prescribe this medication, including via telehealth. Before initiating treatment, prescribers should evaluate urinary symptoms, obtain baseline PSA, assess for prostate cancer, and review current medications for interactions.
Urologists — primary specialists for BPH; recommended for complex cases
Primary Care Physicians (PCPs) — family medicine and internal medicine doctors routinely manage BPH
Internists and Geriatricians — especially relevant for older men with multiple comorbidities
Nurse Practitioners (NPs) and Physician Assistants (PAs) — licensed to prescribe BPH medications in all 50 states
Telehealth prescribing is widely available for dutasteride/tamsulosin. General telehealth platforms (Teladoc, MDLive, AmWell) and men's health platforms (Ro Health, Hims) can evaluate BPH and prescribe this medication after reviewing symptom history and relevant labs including PSA.
No. Dutasteride/tamsulosin (Jalyn) is not a controlled substance. Neither dutasteride nor tamsulosin is scheduled under the DEA Controlled Substances Act. There are no special prescribing restrictions, no limits on refills beyond standard prescription law, and no restrictions on telehealth prescribing. Any licensed prescriber with prescribing authority can prescribe this medication, including nurse practitioners, physician assistants, and telehealth providers.
However, patients taking dutasteride-containing products (including dutasteride/tamsulosin) must not donate blood until at least 6 months after their last dose. Dutasteride can be absorbed through the skin and could harm male fetal development if a pregnant woman received a transfusion containing dutasteride. This is a donor safety requirement, not a controlled substance restriction.
The most commonly reported side effects of dutasteride/tamsulosin (Jalyn) in clinical trials include:
Ejaculation disorders (delayed ejaculation, retrograde ejaculation, or reduced ejaculate volume) — most common, especially early in treatment
Impotence / erectile dysfunction
Decreased libido (reduced sex drive)
Breast enlargement (gynecomastia) and tenderness
Dizziness (especially when standing up quickly)
Runny or stuffy nose (rhinitis)
Orthostatic hypotension — sudden drop in blood pressure when standing; risk of fainting or falls
Priapism — rare (<1 in 50,000): persistent, painful erection requiring emergency care
Intraoperative Floppy Iris Syndrome (IFIS) — during cataract/glaucoma surgery; inform ophthalmologist before any eye surgery
Slight increased risk of high-grade prostate cancer — overall prostate cancer risk is reduced; regular PSA monitoring required
Serious allergic reactions — rare; seek emergency care for hives, facial swelling, difficulty breathing
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Dutasteride (Avodart)
The 5-ARI component of Jalyn taken alone. Shrinks the prostate over time but lacks the alpha-blocker effect of tamsulosin for faster urinary symptom relief.
Tamsulosin (Flomax)
The alpha-blocker component of Jalyn taken alone. Provides fast relief of BPH urinary symptoms but does not shrink the prostate or reduce long-term disease progression risk.
Finasteride (Proscar)
An alternative 5-ARI that inhibits only type 2 5-alpha reductase. Similar BPH efficacy to dutasteride in clinical trials; available as very inexpensive generic ($4–$10/month). Can be combined with any alpha-blocker.
Silodosin (Rapaflo)
A highly selective alpha-1A blocker; an alternative to tamsulosin for BPH urinary symptom relief. Higher rate of retrograde ejaculation than tamsulosin. Requires new prescription.
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PDE5 inhibitors (sildenafil, tadalafil, vardenafil)
majorBoth PDE5 inhibitors and tamsulosin lower blood pressure. Combined use can cause significant hypotension, dizziness, and fainting. Use with caution under medical supervision only.
Other alpha-blockers (alfuzosin, silodosin, doxazosin)
majorCombining two alpha-blockers causes additive hypotension. Do not use with other alpha-adrenergic blockers.
Strong CYP3A4 inhibitors (ketoconazole, ritonavir, itraconazole)
majorIncrease blood levels of both dutasteride and tamsulosin, potentially increasing side effects. Use with caution; dose adjustment may be needed.
CYP2D6 inhibitors (paroxetine, fluoxetine, bupropion)
moderateIncrease tamsulosin blood levels. Paroxetine increases tamsulosin AUC by 1.6x. Monitor for increased blood pressure side effects.
Warfarin (Coumadin)
moderateLimited data; exercise caution. Monitor INR closely when starting or stopping dutasteride/tamsulosin in patients on warfarin.
Grapefruit juice
minorCYP3A4 inhibition via grapefruit can increase dutasteride and tamsulosin levels. Limit or avoid grapefruit during treatment.
Dutasteride/tamsulosin (Jalyn) represents one of the most evidence-backed combination approaches to BPH management, supported by the landmark 4,844-patient CombAT clinical trial. It simultaneously addresses both the structural enlargement of the prostate (via dutasteride's 5-ARI mechanism) and the functional muscle tension (via tamsulosin's alpha-blockade), producing better outcomes than either drug alone over 4 years. For men with moderate-to-severe BPH, prostate volume ≥30 mL, and elevated PSA, this combination can meaningfully reduce the risk of acute urinary retention, BPH disease progression, and the need for prostate surgery.
The drug is not in shortage as of 2026, though the combination product can be harder to find at some local pharmacies than the individual generics. Patients and providers should be aware that prescribing dutasteride 0.5 mg and tamsulosin 0.4 mg as separate generics is therapeutically equivalent and often more accessible and affordable. With discount coupons, the combined cost of the individual generics can be as low as $19–$50 per month.
If you're having trouble finding dutasteride/tamsulosin at your pharmacy, use medfinder to quickly locate which pharmacies near you have it in stock — saving you hours of phone calls. medfinder calls pharmacies on your behalf and texts you the results, so you can focus on your health rather than your pharmacy hunt.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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Medfinder is actively checking pharmacy inventory for Dutasteride/Tamsulosin. We don't publish a number until we have enough verified pharmacy checks to be accurate — start a search and our team confirms current availability near you, usually within 24 hours.
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