Comprehensive medication guide to Anafranil including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$10–$50/month
Estimated Cash Pricing
$15–$600/month
Medfinder Findability Score
55/100
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Anafranil (Clomipramine Hydrochloride) is a tricyclic antidepressant (TCA) that is FDA-approved for the treatment of Obsessive-Compulsive Disorder (OCD) in patients aged 10 and older. It is widely considered the most effective medication for OCD, particularly when SSRIs have not provided adequate relief. Clomipramine is also used off-label for major depressive disorder, anxiety disorders, panic disorder, chronic pain, and premature ejaculation.
25 mg oral capsule — capsule
used for initial dosing and titration
50 mg oral capsule — capsule
common maintenance dose
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75 mg oral capsule — capsule
used for higher maintenance dosing
Serious side effects to watch for include seizures (risk increases at higher doses), serotonin syndrome, QT prolongation, and orthostatic hypotension. Contact your doctor immediately if you experience any concerning symptoms.
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Fluvoxamine (Luvox)
SSRI, FDA-approved for OCD with fewer side effects than Clomipramine
Fluoxetine (Prozac)
SSRI, FDA-approved for OCD, well-studied and widely available
Sertraline (Zoloft)
SSRI, FDA-approved for OCD, generally well-tolerated
Paroxetine (Paxil)
SSRI, FDA-approved for OCD, also treats anxiety and panic disorder
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MAOIs
moderateContraindicated. Must wait at least 14 days between stopping an MAOI and starting Anafranil (risk of seizures, coma, death)
SSRIs and serotonergic drugs
moderateIncreased risk of serotonin syndrome
CYP2D6 inhibitors
moderate(Fluoxetine, Paroxetine, Quinidine) — Can significantly increase Clomipramine blood levels
CYP1A2 inhibitors
moderate(Fluvoxamine, Ciprofloxacin) — Can increase Clomipramine levels
Alcohol and CNS depressants
moderateEnhanced sedation
Linezolid and IV Methylene Blue
moderateSerotonin syndrome risk
QT-prolonging medications
moderateIncreased risk of cardiac arrhythmias
Anticholinergic drugs
moderateAdditive side effects (dry mouth, constipation, urinary retention)
Tramadol, Triptans, St. John's Wort, Lithium
moderateSerotonin syndrome risk
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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