Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Fluvoxamine XR (extended-release) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. Its generic name is Fluvoxamine Maleate Extended-Release, and it was previously sold under the brand name Luvox CR, which has since been discontinued.
Fluvoxamine XR is FDA-approved to treat:
It is also prescribed off-label for major depressive disorder, generalized anxiety disorder, PTSD, panic disorder, and other conditions. The extended-release formulation allows for once-daily dosing at bedtime, which can improve adherence and reduce daytime side effects like nausea.
Fluvoxamine XR works by selectively blocking the reuptake of serotonin (5-HT) at the presynaptic neuron. This increases the amount of serotonin available in the brain's synaptic cleft, which helps regulate mood, anxiety, and obsessive-compulsive behaviors.
Fluvoxamine also has sigma-1 receptor agonist activity, which may contribute to its anxiolytic (anti-anxiety) effects and distinguishes it from other SSRIs. The extended-release capsule provides a steady release of medication over 24 hours, allowing once-daily dosing at bedtime.
The typical starting dose is 100 mg taken once daily at bedtime, with increases of 50 mg per week up to a maximum of 300 mg daily as tolerated. Note: Fluvoxamine immediate-release tablets are also available in 25 mg, 50 mg, and 100 mg strengths.
Fluvoxamine XR has a findability score of 35 out of 100, meaning it is significantly difficult to find in stock at most pharmacies. An active shortage has been ongoing since February 2024, with both generic manufacturers — Par Pharmaceuticals and Teva Pharmaceuticals — reporting supply chain issues. Many pharmacies have limited or no stock, and patients frequently report being turned away or placed on waitlists.
If you're struggling to find Fluvoxamine XR, try using Medfinder to locate pharmacies with current stock near you, or ask your doctor about switching to Fluvoxamine immediate-release tablets, which are more widely available.
Struggling to find {drug} in stock? We'll call the pharmacies, sit on hold, and find you one that can fill your prescription.
Fluvoxamine XR can be prescribed by any licensed physician or authorized prescriber. The most common prescribing specialties include:
Telehealth prescribing is also available for Fluvoxamine XR since it is not a controlled substance.
No. Fluvoxamine XR is not a controlled substance and has no DEA schedule. It does not have abuse potential and does not require special prescribing restrictions like stimulants or benzodiazepines. Prescriptions can be called in, sent electronically, and refilled without the limitations that apply to scheduled medications.
Serious side effects to watch for include suicidal thoughts (especially in young adults under 25), serotonin syndrome, seizures, abnormal bleeding, and hyponatremia. Fluvoxamine XR carries a boxed warning about increased risk of suicidal thinking and behavior in children, adolescents, and young adults. Contact your doctor immediately if you experience worsening depression or unusual changes in behavior.
If you cannot find Fluvoxamine XR in stock, your doctor may consider the following alternatives:
Always consult your prescriber before switching medications.
Fluvoxamine is a potent inhibitor of CYP1A2 and CYP2C19, which means it can significantly increase blood levels of many other medications. Key interactions include:
Always inform your doctor and pharmacist of all medications, supplements, and herbal products you take.
Fluvoxamine XR is an effective SSRI for treating OCD and social anxiety disorder, but the ongoing shortage since February 2024 has made it challenging to find. With only two generic manufacturers (Par Pharmaceuticals and Teva) and both experiencing supply issues, patients may face delays filling prescriptions.
If you're having trouble finding Fluvoxamine XR, use Medfinder to check pharmacy stock near you — or talk to your doctor about temporarily switching to Fluvoxamine immediate-release tablets or an alternative SSRI while supply recovers.
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