Comprehensive medication guide to Fluvoxamine XR including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
Most insurance plans cover generic Fluvoxamine XR at Tier 2 or Tier 3, with typical copays of $20–$75.
Estimated Cash Pricing
Generic Fluvoxamine XR costs $170–$440 retail for 30 capsules; with coupons as low as $75–$107.
Medfinder Findability Score
35/100
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Fluvoxamine XR (extended-release) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. Its generic name is Fluvoxamine Maleate Extended-Release, and it was previously sold under the brand name Luvox CR, which has since been discontinued.
Fluvoxamine XR is FDA-approved to treat:
It is also prescribed off-label for major depressive disorder, generalized anxiety disorder, PTSD, panic disorder, and other conditions. The extended-release formulation allows for once-daily dosing at bedtime, which can improve adherence and reduce daytime side effects like nausea.
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Fluvoxamine XR works by selectively blocking the reuptake of serotonin (5-HT) at the presynaptic neuron. This increases the amount of serotonin available in the brain's synaptic cleft, which helps regulate mood, anxiety, and obsessive-compulsive behaviors.
Fluvoxamine also has sigma-1 receptor agonist activity, which may contribute to its anxiolytic (anti-anxiety) effects and distinguishes it from other SSRIs. The extended-release capsule provides a steady release of medication over 24 hours, allowing once-daily dosing at bedtime.
100 mg extended-release capsules
150 mg extended-release capsules
Fluvoxamine XR has a findability score of 35 out of 100, meaning it is significantly difficult to find in stock at most pharmacies. An active shortage has been ongoing since February 2024, with both generic manufacturers — Par Pharmaceuticals and Teva Pharmaceuticals — reporting supply chain issues. Many pharmacies have limited or no stock, and patients frequently report being turned away or placed on waitlists.
If you're struggling to find Fluvoxamine XR, try using Medfinder to locate pharmacies with current stock near you, or ask your doctor about switching to Fluvoxamine immediate-release tablets, which are more widely available.
Fluvoxamine XR can be prescribed by any licensed physician or authorized prescriber. The most common prescribing specialties include:
Telehealth prescribing is also available for Fluvoxamine XR since it is not a controlled substance.
No. Fluvoxamine XR is not a controlled substance and has no DEA schedule. It does not have abuse potential and does not require special prescribing restrictions like stimulants or benzodiazepines. Prescriptions can be called in, sent electronically, and refilled without the limitations that apply to scheduled medications.
Serious side effects to watch for include suicidal thoughts (especially in young adults under 25), serotonin syndrome, seizures, abnormal bleeding, and hyponatremia. Fluvoxamine XR carries a boxed warning about increased risk of suicidal thinking and behavior in children, adolescents, and young adults. Contact your doctor immediately if you experience worsening depression or unusual changes in behavior.
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Fluvoxamine IR (immediate-release tablets)
the same active ingredient in a twice-daily formulation; much more widely available at $16–$22 with coupons
Sertraline (Zoloft)
another SSRI, FDA-approved for OCD, also treats depression and anxiety; widely available generic
Paroxetine (Paxil/Paxil CR)
SSRI approved for OCD, social anxiety, GAD, panic disorder, and PTSD; available in IR and CR formulations
Fluoxetine (Prozac)
SSRI approved for OCD and depression; long half-life, widely available, very affordable generic
Clomipramine (Anafranil)
tricyclic antidepressant FDA-approved for OCD; more side effects but effective for treatment-resistant cases
Prefer Fluvoxamine XR? We can find it.
MAOIs
moderatecontraindicated; risk of serotonin syndrome
Tizanidine
moderatecontraindicated; causes severe hypotension and sedation
Thioridazine and Pimozide
moderatecontraindicated; risk of QTc prolongation
Theophylline
moderatemarkedly increased levels due to CYP1A2 inhibition
Warfarin
moderateincreased levels and bleeding risk
Benzodiazepines (alprazolam, triazolam, midazolam)
moderatesignificantly increased levels
Clozapine
moderatesignificantly increased levels
Caffeine
moderateFluvoxamine can increase caffeine levels up to 5-fold; reduce caffeine intake
Triptans
moderaterisk of serotonin syndrome
Fluvoxamine XR is an effective SSRI for treating OCD and social anxiety disorder, but the ongoing shortage since February 2024 has made it challenging to find. With only two generic manufacturers (Par Pharmaceuticals and Teva) and both experiencing supply issues, patients may face delays filling prescriptions.
If you're having trouble finding Fluvoxamine XR, use Medfinder to check pharmacy stock near you — or talk to your doctor about temporarily switching to Fluvoxamine immediate-release tablets or an alternative SSRI while supply recovers.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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