Comprehensive medication guide to Amoxicillin/Vonoprazan including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$25–$150 copay depending on plan tier (typically Tier 3–4); prior authorization is often required. Commercially insured patients eligible for the Voquezna Savings Card may pay as little as $25 per fill.
Estimated Cash Pricing
$835–$1,014 retail for the 14-day branded course (Voquezna Dual Pak); GoodRx coupons bring the price to approximately $859. No generic is available. Phathom Pharmaceuticals' Savings Card reduces cost to as little as $25 for eligible commercially insured patients.
Medfinder Findability Score
52/100
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Amoxicillin/Vonoprazan is a prescription combination medication sold under the brand name Voquezna Dual Pak, manufactured by Phathom Pharmaceuticals. It co-packages two distinct drugs in dosing cards: vonoprazan (a first-in-class potassium-competitive acid blocker, or PCAB) and amoxicillin (a penicillin-class antibiotic).
The FDA approved Voquezna Dual Pak on May 3, 2022, for the treatment of Helicobacter pylori (H. pylori) infection in adults. The drug became commercially available in U.S. pharmacies in December 2023 following resolution of a nitrosamine impurity issue. It is not a controlled substance and requires no DEA scheduling.
The standard treatment course is 14 days: vonoprazan 20 mg twice daily (morning and evening) plus amoxicillin 1,000 mg (two 500 mg capsules) three times daily. Both can be taken with or without food.
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Vonoprazan blocks the proton pump (H+/K+-ATPase) in stomach parietal cells through potassium-competitive ionic binding. Unlike traditional proton pump inhibitors (PPIs), vonoprazan works on both active and inactive pumps, doesn't require acid activation, and achieves maximum acid suppression from the first dose. This creates a less acidic stomach environment in which antibiotics work more effectively.
Amoxicillin is a bactericidal penicillin antibiotic that disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). Without a functional cell wall, H. pylori bacteria cannot survive. Amoxicillin resistance among H. pylori strains in the U.S. remains below 3%, making it a highly reliable component.
Together, the combination works synergistically: vonoprazan's superior acid suppression activates and stabilizes amoxicillin's antibacterial activity while keeping H. pylori metabolically active and vulnerable. This dual mechanism achieved eradication rates of 78–93% in the PHALCON-HP phase 3 clinical trial, outperforming PPI-based triple therapy in clarithromycin-resistant strains.
Vonoprazan 20 mg + Amoxicillin 500 mg — co-packaged tablet/capsule kit
Vonoprazan 20 mg tablet twice daily + amoxicillin 1,000 mg (2 x 500 mg capsules) three times daily for 14 days
Vonoprazan 20 mg — tablet
One tablet taken morning and evening (12 hours apart), with or without food
Amoxicillin 500 mg — capsule
Two capsules (1,000 mg total) taken morning, midday, and evening
Amoxicillin/Vonoprazan is not in an FDA-listed shortage as of 2026, but it is inconsistently available at pharmacies. As a newer brand-only drug that entered the U.S. market in December 2023, many pharmacies — particularly independent locations — do not routinely stock it. Large chain pharmacies (CVS, Walgreens, Walmart Pharmacy) and hospital outpatient pharmacies are the most reliable sources.
The retail price of $835–$1,014 per course also discourages pharmacies from holding large inventory. Pharmacies can usually special-order Voquezna Dual Pak in 1–3 business days if it's not on the shelf. Availability via mail-order pharmacies and Amazon Pharmacy is generally more reliable.
To find a pharmacy near you with Amoxicillin/Vonoprazan in stock, use medfinder. medfinder calls pharmacies near your location to check real-time availability and delivers results by text, saving you the hassle of calling pharmacy after pharmacy.
Amoxicillin/Vonoprazan (Voquezna Dual Pak) is not a controlled substance and has no DEA scheduling requirements. Any licensed prescriber with standard prescribing authority can write a prescription for it in all 50 states. The following types of providers commonly prescribe it:
Telehealth providers can also prescribe Amoxicillin/Vonoprazan in all 50 states, as it is not a controlled substance. Patients typically need a positive H. pylori test result on file before a telehealth provider will prescribe treatment. Platforms such as Teladoc, MDLive, and Amazon Clinic can facilitate evaluation, testing coordination, and prescribing.
No. Amoxicillin/Vonoprazan (Voquezna Dual Pak) is not a controlled substance and has no DEA scheduling. There are no special prescribing restrictions, no limits on refill quantities, and no requirement for a DEA registration to prescribe it beyond standard prescribing authority.
Any licensed prescriber — including primary care physicians, gastroenterologists, nurse practitioners, and physician assistants — can write a prescription for Voquezna Dual Pak. It can also be prescribed via telehealth in all 50 states. The only requirement is a valid prescription from a licensed healthcare provider, along with confirmation of H. pylori infection.
The following side effects are common and typically mild:
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Bismuth Quadruple Therapy
PPI + bismuth subsalicylate + metronidazole + tetracycline for 14 days. ACG preferred first-line; 85–90% eradication; all generic components cost ~$30–$80 total.
Voquezna Triple Pak
Vonoprazan + amoxicillin + clarithromycin for 14 days. FDA-approved; use when clarithromycin susceptibility is confirmed. Similar cost to Dual Pak at ~$835–$1,000.
Rifabutin Triple Therapy (Talicia)
Omeprazole + amoxicillin + rifabutin TID for 14 days. FDA-approved; very low rifabutin resistance rates (<3%); useful for multidrug-resistant infections. Brand cost $500–$800.
Levofloxacin Triple Therapy
PPI + amoxicillin + levofloxacin for 14 days. Generic salvage therapy (~$20–$60); limited by rising fluoroquinolone resistance (~38% in U.S.).
Prefer Amoxicillin/Vonoprazan? We can find it.
Rilpivirine
majorVonoprazan's acid suppression reduces rilpivirine absorption, risking HIV treatment failure. Contraindicated combination.
St. John's Wort
majorCYP3A4 inducer that significantly decreases vonoprazan exposure, reducing treatment effectiveness. Avoid during treatment.
Rifampin
majorStrong CYP3A4 inducer that reduces vonoprazan levels. Avoid concomitant use.
Clopidogrel (Plavix)
moderateVonoprazan (CYP2C19 inhibitor) may reduce clopidogrel's antiplatelet effect by decreasing active metabolite levels.
Warfarin
moderateAntibiotic-related gut flora changes can alter warfarin anticoagulation. Monitor INR.
Probenecid
moderateBlocks renal tubular secretion of amoxicillin, increasing amoxicillin exposure and potential toxicity.
Iron salts / oral iron
moderateVonoprazan raises gastric pH, potentially reducing iron absorption. Separate timing may be needed.
Ketoconazole / Itraconazole
moderateAntifungals requiring acidic pH for absorption may have reduced bioavailability with vonoprazan.
Mycophenolate mofetil
moderateAltered absorption possible due to vonoprazan's acid suppression.
Amoxicillin/Vonoprazan (Voquezna Dual Pak) represents a meaningful step forward in H. pylori treatment. As a PCAB-based dual therapy, it offers superior acid suppression compared to PPI-based regimens, works from day one, and remains effective against the growing proportion of clarithromycin-resistant H. pylori strains. Its 2024 ACG guideline endorsement as a first-line empiric alternative reflects the strength of its clinical evidence.
The main challenges are cost and availability. At $835–$1,014 retail, it's expensive without insurance help. And as a newer branded medication only available since December 2023, not all pharmacies routinely stock it. For patients who can access it — especially commercially insured patients using the Savings Card — it's an excellent choice for H. pylori eradication therapy. For patients who can't, bismuth quadruple therapy remains a highly effective and affordable alternative.
If you've been prescribed Amoxicillin/Vonoprazan and need help finding it at a pharmacy near you, use medfinder to locate pharmacies with it in stock. Simply enter your medication name and location, and medfinder will call nearby pharmacies and text you the results.
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