How to Save Money on Amoxicillin/Vonoprazan in 2026: Coupons, Discounts, and Patient Assistance

Amoxicillin/Vonoprazan (Voquezna Dual Pak) is a highly effective H. pylori treatment — but at a retail price of $835–$1,014 for a 14-day course, it's also a significant financial burden. If you're uninsured, under-insured, or facing a high copay, here is a complete breakdown of every savings option available in 2026.

What Does Amoxicillin/Vonoprazan Cost Without Insurance?

The average retail cash price for Voquezna Dual Pak is approximately $835–$1,014 for the 14-day treatment course, depending on the pharmacy. There is currently no generic version of this medication — vonoprazan is only available under the Voquezna brand name in the U.S. — which keeps the price high.

The good news is that multiple savings programs exist. Below are all of them, ranked from most savings to least.

Option 1: Voquezna Savings Card (Best for Commercially Insured Patients)

The Voquezna Savings Card from Phathom Pharmaceuticals is the best available savings option for commercially insured patients. Here are the key terms:

• Cost: As little as $25 per fill (subject to a per-fill cap of $316)
• Eligible for: U.S. residents 18+ with commercial insurance that covers Voquezna Dual Pak
• Number of fills: Good for up to 2 fills
• Not available to: Medicare, Medicaid, TRICARE, VA, or other government program enrollees
• Card expiration: 12/31/2026

To activate the card, visit voquezna.com/hp/savings-card and answer the eligibility questions. The card can then be shared directly with your pharmacy.

Option 2: GoodRx Coupons

GoodRx offers a coupon for Voquezna Dual Pak that can bring the price to approximately $858.82 — about 15% off the average retail price of $1,013.69. While this is a more modest discount than some other drugs (GoodRx typically saves 50–80% on generics), it still represents real savings on an expensive brand-only medication.

GoodRx coupons work at most major pharmacy chains, require no registration (though creating a free account unlocks better prices), and have no insurance requirement. They cannot generally be combined with Medicare Part D coverage.

Option 3: Use Your Insurance (and Shop for Better Tiers)

Most commercial insurance plans list Voquezna Dual Pak at Tier 3 or Tier 4. Your out-of-pocket cost depends on your specific plan structure, but with insurance approval and the Savings Card, many commercially insured patients pay just $25.

Tips for reducing costs through insurance:

• Ask your doctor to submit a prior authorization as early as possible — some plans require this before they'll cover Voquezna Dual Pak.
• Ask your insurance plan if it's covered through their mail-order pharmacy at a lower copay.
• If denied coverage, ask your doctor to appeal or request a formulary exception citing the 2024 ACG guidelines.

Option 4: Medicare and Medicaid Patients

Medicare and Medicaid patients are not eligible for the manufacturer Savings Card. For Medicare Part D enrollees, coverage depends on your specific plan's formulary. As of 2025, the Part D annual out-of-pocket cap is $2,000, which limits catastrophic prescription costs.

If Voquezna Dual Pak is not on your Part D formulary or carries an unaffordable Tier 5 coinsurance, discuss the following with your doctor: bismuth quadruple therapy (generic, ~$30–$80) is an effective, accessible, and guideline-supported alternative for Medicare patients.

Option 5: Consider a Lower-Cost Alternative Regimen

If cost is the primary barrier, bismouth quadruple therapy — using generic omeprazole, bismuth subsalicylate (Pepto-Bismol), metronidazole, and tetracycline — achieves 85–90% H. pylori eradication and costs just $30–$80 total. This is the ACG preferred first-line regimen and is far more affordable. See: Alternatives to Amoxicillin/Vonoprazan.

Is There a Patient Assistance Program for Voquezna Dual Pak?

As of 2026, Phathom Pharmaceuticals has not announced a formal Patient Assistance Program (PAP) for free or reduced-cost Voquezna Dual Pak for uninsured or low-income patients. Contact Phathom Pharmaceuticals at 1-888-775-7428 to ask about any current assistance options.

The Bottom Line

For commercially insured patients, the Voquezna Savings Card (as little as $25 per fill) combined with insurance coverage is the best way to make Amoxicillin/Vonoprazan affordable. For uninsured patients, GoodRx brings the price to approximately $859 — still high, making a lower-cost alternative like bismuth quadruple therapy worth discussing with your doctor. If cost isn't the issue but availability is, use medfinder.com to find a pharmacy near you with Voquezna Dual Pak in stock.