What Is Tribenzor? Uses, Dosage, and What You Need to Know in 2026

Tribenzor is a combination prescription medication used to treat high blood pressure (hypertension) in adults. It contains three drugs in a single tablet — olmesartan medoxomil, amlodipine, and hydrochlorothiazide — each working through a different mechanism to lower blood pressure. This guide explains what Tribenzor is, who it's for, how to take it, and what you need to know before starting.

What Is Tribenzor?

Tribenzor is a brand-name oral tablet first approved by the FDA in 2010. It is currently marketed by Cosette Pharmaceuticals, Inc. Generic versions (olmesartan/amlodipine/hydrochlorothiazide) are available from manufacturers including Teva and Par Health USA.

The three active ingredients are:

Olmesartan medoxomil — an angiotensin II receptor blocker (ARB) that blocks a hormone causing blood vessels to tighten

Amlodipine — a dihydropyridine calcium channel blocker (CCB) that relaxes artery walls to reduce resistance

Hydrochlorothiazide (HCTZ) — a thiazide diuretic (water pill) that helps kidneys remove excess salt and water to reduce blood volume

What Is Tribenzor Used For?

Tribenzor is FDA-approved for the treatment of hypertension (high blood pressure) in adults. It is specifically indicated as a substitution or add-on therapy for patients who are not adequately controlled on any two of the following classes: ARBs, calcium channel blockers, or thiazide diuretics.

Important: Tribenzor is not for first-time blood pressure treatment. It is meant for patients who have already tried simpler regimens and still need better control. Lowering blood pressure with Tribenzor reduces the risk of stroke, heart attack, and kidney damage.

What Are the Available Strengths of Tribenzor?

Tribenzor is available in five strength combinations (olmesartan / amlodipine / HCTZ):

20 mg / 5 mg / 12.5 mg (starting dose for most patients)

40 mg / 5 mg / 12.5 mg

40 mg / 5 mg / 25 mg

40 mg / 10 mg / 12.5 mg

40 mg / 10 mg / 25 mg (maximum dose)

How Do You Take Tribenzor?

Tribenzor is taken once daily, by mouth. Your dose will be individualized by your prescriber based on your prior treatment. Key points:

Take it at the same time every day, with or without food (food does not affect absorption)

Take it in the morning or early afternoon to avoid HCTZ-induced nighttime urination

The dose may be increased at 2-week intervals if blood pressure isn't adequately controlled

Maximum antihypertensive effects are usually seen within 2 weeks of a dose change

Never stop Tribenzor suddenly without medical guidance — blood pressure can spike dangerously

Who Should NOT Take Tribenzor?

Tribenzor is not appropriate for everyone. Do not take Tribenzor if you:

Are pregnant or planning to become pregnant (carries a boxed warning for fetal toxicity)

Have anuria (inability to produce urine)

Have a hypersensitivity to sulfonamide-derived drugs (the HCTZ component is a sulfonamide)

Have severe renal impairment (CrCl ≤30 mL/min)

Take aliskiren and have diabetes or kidney disease (contraindicated combination)

Are 75 years or older (amlodipine should start at 2.5 mg, a dose not available in this combination)

Are breastfeeding

Is Tribenzor a Controlled Substance?

No. Tribenzor is not a controlled substance and has no DEA schedule. Any licensed prescriber with prescription-writing authority can prescribe it.

How Does Tribenzor Compare to Other Blood Pressure Medications?

Tribenzor is unique in combining three complementary classes of antihypertensives into one pill. Most blood pressure medications are single-ingredient (like lisinopril, amlodipine, or HCTZ alone). Dual-combination pills like Azor (olmesartan/amlodipine) or Benicar HCT (olmesartan/HCTZ) include two classes. Tribenzor is one of the few triple-combination pills available, alongside Exforge HCT (amlodipine/valsartan/HCTZ).

Also read: How Does Tribenzor Work? Mechanism of Action Explained in Plain English

Having trouble filling your Tribenzor prescription? medfinder calls local pharmacies on your behalf to find which ones have your exact strength in stock.