What Is Quillichew ER?

Quillichew ER is a prescription medication used to treat Attention Deficit Hyperactivity Disorder (ADHD) in patients aged 6 years and older. It contains methylphenidate hydrochloride, the same active ingredient found in well-known ADHD medications like Concerta and Ritalin.

What makes Quillichew ER unique is its form: it's an extended-release chewable tablet with a cherry flavor. This makes it especially helpful for children and adults who have trouble swallowing pills — a common barrier to ADHD treatment.

Quillichew ER is manufactured by Tris Pharma and marketed by Pfizer. It is classified as a Schedule II controlled substance by the DEA due to its potential for abuse and dependence.

What Is Quillichew ER Used For?

Quillichew ER is FDA-approved for one indication:

• ADHD in patients aged 6 and older

ADHD is a neurodevelopmental condition characterized by inattention, hyperactivity, and impulsivity. Quillichew ER helps manage these symptoms by increasing the levels of certain brain chemicals (dopamine and norepinephrine) that play a role in attention and behavior. For a detailed explanation, see our article on how Quillichew ER works.

While other forms of methylphenidate are sometimes used off-label for narcolepsy or treatment-resistant depression, Quillichew ER is specifically designed and approved for ADHD.

Available Dosages

Quillichew ER comes in three strengths:

• 20 mg — Can be split into two 10 mg halves
• 30 mg — Can be split into two 15 mg halves
• 40 mg

The typical dose range is 20 mg to 60 mg once daily. Your doctor will usually start at a lower dose and adjust based on how you respond and any side effects you experience.

The ability to split tablets is a major advantage. It allows for more precise dosing — for example, a child might start at 10 mg (half of a 20 mg tablet) before moving to 20 mg.

How to Take Quillichew ER

Here are the key instructions for taking Quillichew ER correctly:

• Take once daily in the morning
• Chew the tablet completely before swallowing — do not swallow it whole
• Can be taken with or without food
• If splitting a tablet, store the unused half in the original bottle and use it within a few days
• Do not crush and dissolve the tablets, as this could affect the extended-release mechanism

Why the Morning?

Quillichew ER is designed to release medication throughout the day — about 30% releases immediately and 70% releases gradually over several hours. Taking it in the morning ensures coverage during school or work hours while minimizing sleep-related side effects.

How Quillichew ER Is Different from Other ADHD Medications

There are many ADHD medications on the market. Here's how Quillichew ER compares:

• vs. Concerta — Concerta is also extended-release methylphenidate, but it's a tablet that must be swallowed whole. Quillichew ER is chewable.
• vs. Ritalin LA — Ritalin LA is a capsule that can be opened and sprinkled on food. Quillichew ER is chewed directly.
• vs. Quillivant XR — Quillivant XR is a liquid (oral suspension) form of extended-release methylphenidate, also made by Tris Pharma. Good for patients who can't chew tablets either.
• vs. Vyvanse — Vyvanse is a different stimulant altogether (lisdexamfetamine, an amphetamine prodrug) and works through a different mechanism.

For a complete comparison, read our guide on alternatives to Quillichew ER.

Important Safety Information

Boxed Warning

Quillichew ER carries a boxed warning — the most serious type of FDA warning. It states that CNS stimulants, including Quillichew ER, have a high potential for abuse and dependence. Your doctor should assess your risk before prescribing and monitor you throughout treatment.

Who Should NOT Take Quillichew ER

Do not take Quillichew ER if you:

• Are allergic to methylphenidate or any of its ingredients
• Are currently taking or have taken a monoamine oxidase inhibitor (MAOI) within the past 14 days — this combination can cause a dangerous spike in blood pressure

Phenylalanine Warning

Quillichew ER contains phenylalanine:

• 20 mg tablet: 3 mg phenylalanine
• 30 mg tablet: 4.5 mg phenylalanine
• 40 mg tablet: 6 mg phenylalanine

If you or your child has phenylketonuria (PKU), discuss this with your doctor before starting Quillichew ER.

Pregnancy and Breastfeeding

There is limited data on Quillichew ER use during pregnancy. Methylphenidate is present in breast milk. Talk to your doctor about the risks and benefits if you are pregnant, planning to become pregnant, or breastfeeding.

Common Side Effects

The most common side effects include:

• Decreased appetite
• Nausea and stomach pain
• Insomnia
• Headache
• Weight loss
• Irritability

For a complete breakdown of what to watch for, read our detailed guide on Quillichew ER side effects.

Drug Interactions

Quillichew ER can interact with other medications, including MAOIs, blood pressure medications, blood thinners, and certain antidepressants. Always tell your doctor about every medication and supplement you take. See our full article on Quillichew ER drug interactions.

Cost and Availability in 2026

Quillichew ER costs approximately $300–$450 for 30 tablets without insurance. There is currently no generic version available.

Insurance coverage varies. Many plans require prior authorization, and some don't cover it at all. However, savings programs can significantly reduce your out-of-pocket cost:

• Tris Pharma Co-pay Savings Program — Pay as little as $25/prescription for commercially insured patients (coupon.trisadhd.com)
• Pfizer RxPathways — Free medication for eligible uninsured patients (pfizerrxpathways.com)

For more cost-saving strategies, see our guide on how to save money on Quillichew ER.

Finding Quillichew ER in stock can also be a challenge due to the ongoing stimulant shortage. Use MedFinder to locate pharmacies with availability near you, or read our tips on finding Quillichew ER in stock.

Key Takeaways

• Quillichew ER is a chewable, cherry-flavored, extended-release methylphenidate tablet for ADHD
• It's approved for patients aged 6 and older, with doses from 20 mg to 60 mg daily
• Take it in the morning, chew completely, and never combine with MAOIs
• It's a Schedule II controlled substance — expect regular doctor visits and no automatic refills
• No generic is available; retail cost is $300–$450, but savings programs can bring it as low as $25