What Is Prolate? Uses, Dosage, and What You Need to Know in 2026

Prolate is a brand-name prescription pain medication that combines two different types of pain relievers in a single tablet. If you've been prescribed Prolate or are trying to understand what it is, this guide covers the essentials: what it treats, how it's used, what makes it different from other similar medications, and what you need to know to use it safely.

What Is Prolate?

Prolate is the brand name for oxycodone hydrochloride and acetaminophen tablets, manufactured by Forte Bio-Pharma LLC. Each tablet contains two active ingredients:

Oxycodone hydrochloride: A powerful opioid (narcotic) analgesic that acts on the brain and spinal cord to reduce the perception of pain

Acetaminophen (APAP): A widely used non-opioid pain reliever that works through a different mechanism and enhances the opioid's effect

Prolate is a Schedule II controlled substance (CII) under the DEA's Controlled Substances Act. This is the most restrictive category for drugs that have accepted medical uses — meaning oxycodone has a high potential for misuse and dependence.

What Is Prolate Used For?

Prolate is FDA-approved for the management of pain severe enough to require an opioid analgesic and for which non-opioid alternatives are inadequate. In practice, it is commonly prescribed for:

Post-surgical pain (after orthopedic surgery, major abdominal surgery, etc.)

Trauma-related pain (injuries, fractures)

Chronic pain conditions when other non-opioid medications have not provided adequate relief

Cancer-related pain (as part of a broader pain management plan)

What Makes Prolate Different from Percocet?

Prolate and Percocet are both brand names for oxycodone/acetaminophen combinations. The key clinical difference: Prolate tablets contain 300mg of acetaminophen, while Percocet and most generics contain 325mg per tablet. This 25mg reduction per tablet may seem small, but for patients taking 4–6 doses daily, it meaningfully reduces cumulative acetaminophen exposure — relevant for patients near the safety threshold for daily APAP intake.

Available Strengths and Dosing

Prolate comes in three strengths:

Prolate 5mg/300mg: 1 tablet every 6 hours as needed for pain (maximum 12 tablets per day)

Prolate 7.5mg/300mg: 1 tablet every 6 hours as needed (maximum 8 tablets per day)

Prolate 10mg/300mg: 1 tablet every 6 hours as needed (maximum 6 tablets per day)

The total daily dose of acetaminophen from Prolate should not push you over 4,000mg/day from all sources combined. Always take the lowest dose that provides adequate pain relief.

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How to Take Prolate

Take Prolate exactly as prescribed — do not adjust your dose without talking to your doctor

Swallow tablets whole — do not crush, chew, or dissolve them

You can take Prolate with or without food; food may reduce nausea

Do not drink alcohol while taking Prolate

Store securely, away from children and anyone who doesn't have a prescription for it

Important Rules for Schedule II Prescriptions

No refills. Each fill of Prolate requires a new prescription from your provider.

Cannot be transferred. Unlike some medications, Schedule II prescriptions cannot be transferred between pharmacies.

No mail-order. Schedule II drugs generally cannot be dispensed by mail-order pharmacies.

Finding Prolate in stock can be challenging. medfinder is a paid service that contacts pharmacies near you to find which ones can fill your prescription — saving you from calling every pharmacy yourself.

For a full review of Prolate's side effects and safety profile, see our post on Prolate side effects: what to expect and when to call your doctor.