Updated: March 26, 2026
What Is Lymepak? Uses, Dosage, and What You Need to Know in 2026
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Peter Daggett
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Overview
Lymepak is a doxycycline hyclate antibiotic FDA-approved for early Lyme disease. Learn about its uses, dosage, who can take it, and its current availability status in 2026.
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Lymepak is a brand-name prescription antibiotic that was specifically developed and marketed for the treatment of early Lyme disease. Here's a comprehensive overview of what Lymepak is, how it works, who it's for, and what you need to know about its current availability in 2026.
What Is Lymepak?
Lymepak is the brand name for doxycycline hyclate 100 mg film-coated oral tablets. It was manufactured by Chartwell RX, LLC and received FDA approval in 2018 (NDA 209844). Lymepak belongs to the tetracycline class of antibiotics and was the only brand-name drug specifically FDA-approved and packaged for early Lyme disease treatment.
Lymepak was supplied as a distinctive green, round, film-coated tablet engraved with "LP-1" on one side. It was packaged in child-resistant blister cards of 14 tablets (one week's supply) or a carton of three blister cards (42 tablets — a complete 21-day course).
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What Is Lymepak Used For?
Lymepak is FDA-approved for one specific use: the treatment of early Lyme disease (as evidenced by erythema migrans — the characteristic bull's-eye rash) due to the bacterium Borrelia burgdorferi. It is approved for:
Adults
Pediatric patients 8 years of age and older who weigh at least 45 kg (99 lbs)
Lyme disease is a spirochetal infection transmitted by the bite of infected Ixodid (black-legged) ticks. It is caused by Borrelia burgdorferi and is one of the most common tick-borne illnesses in the United States, particularly in the Northeast, Mid-Atlantic, Upper Midwest, and Pacific Coast regions.
What Is the Lymepak Dosage?
The FDA-approved dosing for Lymepak is:
Dose: One 100 mg tablet taken by mouth every 12 hours (twice daily)
Duration: 21 days (the complete course)
Total tablets: 42 tablets
Important: Do not skip doses or stop early even if you feel better. Completing the full 21-day course is essential to ensure that the infection is fully cleared and to reduce the risk of antibiotic resistance. Take each dose approximately 12 hours apart (e.g., 8 AM and 8 PM).
How to Take Lymepak Correctly
Take with food to reduce nausea (a small snack or meal is sufficient)
Swallow with a full glass of water (8 oz.) — do NOT crush or split the tablets
Remain upright for at least 30 minutes after taking to prevent esophageal irritation
Avoid antacids, calcium supplements, dairy, and iron supplements within 2 hours of your dose — they significantly reduce absorption
Wear sunscreen (SPF 30+) and protect your skin from sun exposure for the full 21-day course
Who Should NOT Take Lymepak?
Children under 8 years old or weighing less than 45 kg (permanent tooth discoloration and bone growth risk)
Pregnant women in the second or third trimester (fetal risk)
Breastfeeding women (risk to infant; breastfeeding should be avoided during treatment and for 5 days after the last dose)
Anyone with a known allergy to doxycycline or other tetracycline-class antibiotics
Is Lymepak a Controlled Substance?
No. Lymepak (doxycycline hyclate) is not a controlled substance. It is a prescription-only antibiotic but does not require any special DEA scheduling or prescribing restrictions beyond a standard prescription. It can be prescribed by any licensed healthcare provider including PCPs, NPs, and PAs.
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Lymepak Availability in 2026: What You Need to Know
The Lymepak brand has been discontinued by Chartwell RX, LLC. Patients prescribed Lymepak should ask their pharmacist for generic doxycycline hyclate 100 mg tablets — it is the same drug, same dose, and covered by most insurance plans at Tier 1 (typically $0–$15 copay). See our article on why Lymepak is hard to find for more information. If you're having trouble locating the generic at a local pharmacy, medfinder can help identify pharmacies near you that have it in stock.
Frequently Asked Questions
Lymepak (doxycycline hyclate 100 mg) is FDA-approved specifically for the treatment of early Lyme disease (as evidenced by erythema migrans, the bull's-eye rash) due to Borrelia burgdorferi. It is approved for adults and children 8 years and older who weigh at least 45 kg.
The FDA-approved Lymepak dose is one 100 mg tablet taken by mouth every 12 hours for 21 days — a total of 42 tablets. The same regimen applies to generic doxycycline hyclate, which is the direct equivalent now that the Lymepak brand has been discontinued.
The Lymepak brand was discontinued by its manufacturer, Chartwell RX, LLC. However, the equivalent generic — doxycycline hyclate 100 mg tablets — is widely available at most pharmacies nationwide. Ask your pharmacist for the generic by name.
Lymepak treats early Lyme disease caused by the bacterium Borrelia burgdorferi, specifically when erythema migrans (the characteristic expanding bull's-eye rash) is present. It is not FDA-approved for later stages of Lyme disease with neurologic, cardiac, or joint manifestations, which may require different antibiotics or IV treatment.
The standard Lymepak course is 21 days — one 100 mg tablet every 12 hours. Do not stop early even if symptoms improve. Completing the full course is important to clear the infection and reduce the risk of Lyme disease progressing to later stages.
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