Comprehensive medication guide to Amoxicillin/Clavulanate including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
Most insurance plans cover generic Amoxicillin/Clavulanate as a Tier 1 drug with typical copays of $0 to $15.
Estimated Cash Pricing
Generic Amoxicillin/Clavulanate typically costs $15 to $60 without insurance, depending on strength and quantity, but discount cards can bring the price down to $10 to $25.
Medfinder Findability Score
75/100
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Amoxicillin/Clavulanate (brand name Augmentin) is a combination antibiotic used to treat a wide range of bacterial infections. It combines amoxicillin, a penicillin-type antibiotic, with clavulanate, a beta-lactamase inhibitor that helps amoxicillin work against bacteria that would otherwise resist it.
It is FDA-approved for:
Doctors also commonly prescribe it off-label for dental infections, animal and human bite wounds, diabetic foot infections, and COPD exacerbations.
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Amoxicillin kills bacteria by inhibiting cell wall synthesis — it binds to penicillin-binding proteins, preventing bacteria from building and maintaining their cell walls, which causes them to die. However, some bacteria produce enzymes called beta-lactamases that can destroy amoxicillin before it works.
That's where clavulanate comes in. Clavulanate is a beta-lactamase inhibitor that blocks these enzymes, protecting amoxicillin and extending its effectiveness against a broader range of bacteria. This combination makes Amoxicillin/Clavulanate effective against many infections that plain amoxicillin alone cannot treat.
Tablets
250/125 mg, 500/125 mg, 875/125 mg
Chewable Tablets
125/31.25 mg, 250/62.5 mg
Oral Suspension — suspension
125/31.25 mg, 200/28.5 mg, 250/62.5 mg, 400/57 mg per 5 mL
Extended-Release Tablets (Augmentin XR)
1000/62.5 mg
Amoxicillin/Clavulanate scores a 75 out of 100 on our findability scale, meaning it is generally available but may require some effort to locate depending on the formulation you need. Standard tablets (875/125 mg and 500/125 mg) are usually in stock at most pharmacies. However, oral suspensions and extended-release (XR) tablets have experienced ongoing intermittent shortages since late 2022, with multiple manufacturers reporting back-ordered products through 2025.
If your pharmacy is out of stock, try calling nearby locations or use Medfinder to check real-time availability. Suspensions for pediatric patients may be harder to find — ask your doctor about alternative formulations or compounded options if needed.
Amoxicillin/Clavulanate is one of the most widely prescribed antibiotics and is commonly prescribed by:
It is also widely available through telehealth platforms, which can prescribe it for appropriate indications without an in-person visit.
No. Amoxicillin/Clavulanate is not a controlled substance and does not have a DEA schedule. It is a prescription-only antibiotic with no potential for abuse or dependence. It can be prescribed by any licensed healthcare provider and is available through telehealth.
The most frequently reported side effects include:
Taking Amoxicillin/Clavulanate with food can help reduce gastrointestinal side effects.
Seek immediate medical attention if you experience severe diarrhea, yellowing of the skin or eyes, difficulty breathing, or a severe rash.
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Cefdinir (Omnicef)
A third-generation cephalosporin with a similar spectrum of activity. A good option for patients who can tolerate cephalosporins during Amoxicillin/Clavulanate shortages.
Cephalexin (Keflex)
A first-generation cephalosporin with a narrower spectrum, useful for skin infections and urinary tract infections.
Azithromycin (Zithromax/Z-Pack)
A macrolide antibiotic from a different drug class. Useful for respiratory infections in patients with penicillin allergies.
Doxycycline (Vibramycin)
A broad-spectrum tetracycline antibiotic that can substitute for respiratory and skin infections.
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Warfarin
moderatemay increase INR and bleeding risk; monitor closely
Methotrexate
moderatecan increase methotrexate levels, raising toxicity risk
Probenecid
moderateincreases amoxicillin blood levels
Oral contraceptives
moderatemay reduce effectiveness of birth control pills
Allopurinol
moderateincreased risk of skin rash when taken together
Mycophenolate
moderatemay reduce mycophenolate levels
Amoxicillin/Clavulanate remains one of the most important and widely prescribed antibiotics available. As a generic medication, it is generally affordable — $10 to $25 with a discount card and often $0 to $15 with insurance. While certain formulations like suspensions and extended-release tablets have experienced intermittent shortages since 2022, standard tablets are usually available at most pharmacies.
If you're having trouble finding Amoxicillin/Clavulanate in stock, use Medfinder to search real-time pharmacy availability near you. You can also ask your doctor about alternative strengths or formulations that may be easier to find, or consider one of the alternative antibiotics listed above.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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