Medications

Amoxicillin/Clavulanate

Amoxicillin/Clavulanate

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Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.

Estimated Insurance Pricing
Most insurance plans cover generic Amoxicillin/Clavulanate as a Tier 1 drug with typical copays of $0 to $15.
Estimated Cash Pricing
Generic Amoxicillin/Clavulanate typically costs $15 to $60 without insurance, depending on strength and quantity, but discount cards can bring the price down to $10 to $25.
Medfinder Findability Score
75
/100
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Post Author

Peter Daggett

Last Updated

February 14, 2026

Amoxicillin/Clavulanate 2026 Availability, Prices, and Tips to Find

What is Amoxicillin/Clavulanate and what does it do?

Amoxicillin/Clavulanate (brand name Augmentin) is a combination antibiotic used to treat a wide range of bacterial infections. It combines amoxicillin, a penicillin-type antibiotic, with clavulanate, a beta-lactamase inhibitor that helps amoxicillin work against bacteria that would otherwise resist it.

It is FDA-approved for:

  • Lower respiratory tract infections
  • Acute bacterial sinusitis
  • Otitis media (middle ear infections)
  • Skin and skin structure infections
  • Urinary tract infections
  • Community-acquired pneumonia (XR formulation)

Doctors also commonly prescribe it off-label for dental infections, animal and human bite wounds, diabetic foot infections, and COPD exacerbations.

How does Amoxicillin/Clavulanate work?

Amoxicillin kills bacteria by inhibiting cell wall synthesis — it binds to penicillin-binding proteins, preventing bacteria from building and maintaining their cell walls, which causes them to die. However, some bacteria produce enzymes called beta-lactamases that can destroy amoxicillin before it works.

That's where clavulanate comes in. Clavulanate is a beta-lactamase inhibitor that blocks these enzymes, protecting amoxicillin and extending its effectiveness against a broader range of bacteria. This combination makes Amoxicillin/Clavulanate effective against many infections that plain amoxicillin alone cannot treat.

What doses are available?

  • Tablets: 250/125 mg, 500/125 mg, 875/125 mg
  • Chewable Tablets: 125/31.25 mg, 250/62.5 mg
  • Oral Suspension: 125/31.25 mg, 200/28.5 mg, 250/62.5 mg, 400/57 mg per 5 mL
  • Extended-Release Tablets (Augmentin XR): 1000/62.5 mg

How hard is it to find Amoxicillin/Clavulanate in stock?

Amoxicillin/Clavulanate scores a 75 out of 100 on our findability scale, meaning it is generally available but may require some effort to locate depending on the formulation you need. Standard tablets (875/125 mg and 500/125 mg) are usually in stock at most pharmacies. However, oral suspensions and extended-release (XR) tablets have experienced ongoing intermittent shortages since late 2022, with multiple manufacturers reporting back-ordered products through 2025.

If your pharmacy is out of stock, try calling nearby locations or use Medfinder to check real-time availability. Suspensions for pediatric patients may be harder to find — ask your doctor about alternative formulations or compounded options if needed.

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What kinds of doctors prescribe Amoxicillin/Clavulanate?

Amoxicillin/Clavulanate is one of the most widely prescribed antibiotics and is commonly prescribed by:

  • Primary Care and Family Medicine physicians
  • Pediatricians (very commonly used in children)
  • Internal Medicine doctors
  • Urgent Care providers
  • Emergency Medicine physicians
  • Dentists (for dental infections and abscesses)
  • ENT (Otolaryngology) specialists

It is also widely available through telehealth platforms, which can prescribe it for appropriate indications without an in-person visit.

Is Amoxicillin/Clavulanate a controlled substance?

No. Amoxicillin/Clavulanate is not a controlled substance and does not have a DEA schedule. It is a prescription-only antibiotic with no potential for abuse or dependence. It can be prescribed by any licensed healthcare provider and is available through telehealth.

What are common side effects of Amoxicillin/Clavulanate?

The most frequently reported side effects include:

  • Diarrhea — the most common side effect, affecting up to 34% of patients
  • Nausea and vomiting
  • Skin rash
  • Abdominal pain
  • Vaginal yeast infections
  • Headache

Taking Amoxicillin/Clavulanate with food can help reduce gastrointestinal side effects.

Serious side effects (rare but important)

  • C. difficile-associated diarrhea
  • Cholestatic hepatitis or jaundice (may appear weeks after stopping)
  • Severe allergic reactions or anaphylaxis
  • Stevens-Johnson syndrome
  • Seizures (with high doses or in patients with kidney impairment)

Seek immediate medical attention if you experience severe diarrhea, yellowing of the skin or eyes, difficulty breathing, or a severe rash.

What are some alternative medications?

If you cannot find Amoxicillin/Clavulanate in stock or cannot take it due to allergies, your doctor may consider these alternatives:

  • Cefdinir (Omnicef) — A third-generation cephalosporin with a similar spectrum of activity. A good option for patients who can tolerate cephalosporins during Amoxicillin/Clavulanate shortages.
  • Cephalexin (Keflex) — A first-generation cephalosporin with a narrower spectrum, useful for skin infections and urinary tract infections.
  • Azithromycin (Zithromax/Z-Pack) — A macrolide antibiotic from a different drug class. Useful for respiratory infections in patients with penicillin allergies.
  • Doxycycline (Vibramycin) — A broad-spectrum tetracycline antibiotic that can substitute for respiratory and skin infections.

Always consult your doctor before switching medications — the right alternative depends on your specific infection and medical history.

Does Amoxicillin/Clavulanate interact with other drugs?

Yes. Important drug interactions include:

  • Warfarin — may increase INR and bleeding risk; monitor closely
  • Methotrexate — can increase methotrexate levels, raising toxicity risk
  • Probenecid — increases amoxicillin blood levels
  • Oral contraceptives — may reduce effectiveness of birth control pills
  • Allopurinol — increased risk of skin rash when taken together
  • Mycophenolate — may reduce mycophenolate levels

Always tell your doctor and pharmacist about all medications you're taking, including over-the-counter drugs and supplements.

Final thoughts on Amoxicillin/Clavulanate

Amoxicillin/Clavulanate remains one of the most important and widely prescribed antibiotics available. As a generic medication, it is generally affordable — $10 to $25 with a discount card and often $0 to $15 with insurance. While certain formulations like suspensions and extended-release tablets have experienced intermittent shortages since 2022, standard tablets are usually available at most pharmacies.

If you're having trouble finding Amoxicillin/Clavulanate in stock, use Medfinder to search real-time pharmacy availability near you. You can also ask your doctor about alternative strengths or formulations that may be easier to find, or consider one of the alternative antibiotics listed above.

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