Updated: March 26, 2026
What Is Epaned? Uses, Dosage, and What You Need to Know in 2026
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Peter Daggett
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Overview
Epaned is the only FDA-approved enalapril oral solution, used to treat hypertension and heart failure. Here's everything patients need to know about it in 2026.
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Epaned is the brand name for enalapril maleate oral solution — an FDA-approved liquid blood pressure medication that belongs to a class of drugs called ACE inhibitors (angiotensin-converting enzyme inhibitors). It was first approved by the FDA on August 13, 2013, making it the first and, for a time, the only FDA-approved enalapril oral solution. It is manufactured by Azurity Pharmaceuticals.
Enalapril itself has been used for decades to treat hypertension and heart conditions. Epaned simply delivers that well-established drug in a liquid format — critical for infants, young children, and adults who cannot swallow tablets.
What Is Epaned Approved to Treat?
Epaned is FDA-approved for three indications:
Hypertension (high blood pressure) in adults and children older than one month. This is its most common use, particularly in the pediatric setting where weight-based liquid dosing is essential.
Symptomatic heart failure in adults, when used as part of a comprehensive treatment plan. Enalapril has been shown to reduce hospitalization and improve symptoms in patients with congestive heart failure.
Asymptomatic left ventricular dysfunction (ALVD) in adults, to decrease the rate of development of overt heart failure and reduce hospitalization. This is used in patients who show impaired heart function on imaging but have not yet developed symptoms.
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What Form Does Epaned Come In?
The current Epaned formulation is a ready-to-use oral solution containing 1 mg/mL of enalapril maleate. It has a mixed berry flavor and comes in a 150 mL bottle. Each bottle represents approximately a 30-day supply for most adult patients, though dose and quantity depend on your prescriber's instructions.
An earlier formulation was a powder that required mixing (reconstitution) with a diluent. The current ready-to-use solution eliminates this step, which reduces dosing errors and is more convenient for caregivers of young children.
What Are the Typical Doses for Epaned?
Always take Epaned exactly as prescribed by your doctor. Do not adjust your dose without consulting your healthcare provider. General dosing guidelines include:
Adults with hypertension: Typically start at 5 mg (5 mL) once daily. May be increased gradually up to a maximum of 40 mg per day. Patients with impaired kidney function (eGFR ≤30) start at 2.5 mg.
Adults with heart failure: Typically start at 2.5 mg (2.5 mL) twice daily. May be titrated up to a maximum of 10 mg twice daily as tolerated.
Children older than 1 month with hypertension: 0.08 mg/kg once daily, up to a maximum of 5 mg. Dosing is based on the child's weight and is calculated by the prescriber.
How Should You Take Epaned?
Take Epaned at the same time each day for best results.
It can be taken with or without food.
Use the measuring device provided with the bottle — never a household spoon, which does not measure accurately.
Store Epaned as directed on the label — the ready-to-use oral solution does not require refrigeration when stored at room temperature within the dispensed period.
Do not stop taking Epaned suddenly without talking to your doctor — stopping blood pressure medications abruptly can cause your blood pressure to rise rapidly.
Who Should NOT Take Epaned?
Epaned is contraindicated in patients who:
Are pregnant or may become pregnant (fetal toxicity boxed warning)
Have a history of angioedema related to ACE inhibitor use
Have hereditary or idiopathic angioedema
Are diabetic patients also taking aliskiren (Tekturna)
Are neonates or pediatric patients with an eGFR < 30 mL/min/1.73 m²
Is Epaned a Controlled Substance?
No. Epaned is not a controlled substance and has no DEA schedule. It is a standard prescription medication that can be prescribed by any licensed provider and refilled at any pharmacy that carries it.
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Why Is Epaned Hard to Find at the Pharmacy?
Epaned is a niche liquid medication that most pharmacies don't stock because demand is limited compared to enalapril tablets. For full details on why it's hard to find and how to locate it, see our guide: Why is Epaned hard to find? or visit medfinder to search for pharmacies near you that can fill your prescription.
Frequently Asked Questions
Epaned (enalapril maleate oral solution, 1 mg/mL) is FDA-approved to treat hypertension (high blood pressure) in adults and children older than one month, symptomatic heart failure in adults, and asymptomatic left ventricular dysfunction in adults. It is used when a liquid formulation is needed — such as for infants and young children or adults with difficulty swallowing tablets.
Epaned and enalapril contain the same active drug (enalapril maleate), but Epaned is a liquid oral solution (1 mg/mL) while regular enalapril comes as a tablet. Epaned allows weight-based dosing for children and is easier for patients who can't swallow tablets. Generic enalapril tablets are far less expensive and more widely available.
The ready-to-use Epaned oral solution can be stored at room temperature for a defined period after dispensing (up to 60 days at room temperature when stored in the original packaging, according to FDA guidance). Check the label or ask your pharmacist for the specific storage and expiration instructions for your bottle.
Epaned is FDA-approved for children older than one month of age. It is not recommended for neonates (newborns less than one month old) or for pediatric patients with a glomerular filtration rate (eGFR) less than 30 mL/min/1.73 m². For infants and very young children, dosing is prescribed by a specialist based on weight (0.08 mg/kg per day).
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