Comprehensive medication guide to Qbrelis including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0–$50 copay with Azurity copay card; prior authorization often required since insurers prefer generic Lisinopril tablets.
Estimated Cash Pricing
$690–$800 retail for a 150 mL bottle; no widely available generic oral solution, though generic Lisinopril tablets cost $4–$15.
Medfinder Findability Score
40/100
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Qbrelis is a brand-name prescription medication containing Lisinopril in an oral solution form. It belongs to the angiotensin-converting enzyme (ACE) inhibitor drug class. Qbrelis is FDA-approved to treat hypertension (high blood pressure) in adults and children aged 6 and older, heart failure as adjunctive therapy, and to improve survival after a heart attack in hemodynamically stable patients. Originally approved by the FDA on April 29, 2016, Qbrelis was specifically developed as a liquid formulation for patients who cannot swallow tablets, including pediatric patients and adults with swallowing difficulties (dysphagia). It is manufactured by Azurity Pharmaceuticals.
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Qbrelis works by inhibiting angiotensin-converting enzyme (ACE), which prevents the conversion of angiotensin I to angiotensin II — a powerful vasoconstrictor. By blocking this conversion, Qbrelis causes blood vessels to relax and widen, which lowers blood pressure. It also reduces aldosterone secretion, decreasing sodium and water retention. The combined effect reduces cardiac workload, making it beneficial for patients with heart failure and those recovering from a heart attack. The liquid formulation provides the same mechanism of action as Lisinopril tablets but in an easier-to-take form.
Oral solution — solution
1 mg/mL (150 mL bottle)
Qbrelis (Lisinopril oral solution) scores a 40 out of 100 on our findability scale, meaning it can be quite difficult to locate. As a specialty oral solution manufactured solely by Azurity Pharmaceuticals, Qbrelis is not routinely stocked at most retail pharmacies. Patients may need to call multiple pharmacies or use a specialty pharmacy to obtain it. Intermittent supply disruptions have been reported due to its niche formulation and single-manufacturer status. Using Medfinder can save you significant time by identifying pharmacies that currently have Qbrelis in stock near you.
Qbrelis can be prescribed by a range of healthcare providers, including:
Qbrelis can also be prescribed via telehealth appointments, as ACE inhibitors are commonly managed remotely for blood pressure control.
No, Qbrelis is not a controlled substance. It has no DEA schedule classification and carries no risk of abuse or dependence. You do not need a special prescription to obtain it, though it does require a valid prescription from a licensed healthcare provider. Refills are straightforward and it can be prescribed via telehealth.
Serious side effects that require immediate medical attention include angioedema (swelling of the face, lips, tongue, or throat), hyperkalemia (high potassium levels), acute kidney injury, and severe hypotension. Qbrelis also carries an FDA boxed warning about fetal toxicity — it must be discontinued immediately if pregnancy is detected.
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Lisinopril tablets (Prinivil, Zestril)
The same active ingredient in tablet form at a fraction of the cost ($4–$15 for 30 tablets). Tablets can sometimes be crushed or compounded into a liquid if needed.
Enalapril / Epaned
Another ACE inhibitor that is also available as an FDA-approved oral solution (Epaned), making it a direct liquid alternative.
Captopril
An ACE inhibitor that can be compounded into an oral solution by specialty pharmacies.
Losartan oral suspension
An ARB (angiotensin receptor blocker) that can be compounded into a liquid form, suitable for patients who cannot tolerate ACE inhibitors due to cough or angioedema.
Prefer Qbrelis? We can find it.
Aliskiren (Tekturna)
moderatecontraindicated in patients with diabetes; increases risk of kidney problems and hyperkalemia
ARBs (Losartan, Valsartan, etc.)
moderatedual RAAS blockade increases risk of hypotension, hyperkalemia, and kidney injury
Sacubitril/Valsartan (Entresto)
moderatemust not be used within 36 hours of Qbrelis due to severe angioedema risk
Potassium-sparing diuretics (Spironolactone, Eplerenone)
moderateincreased hyperkalemia risk
NSAIDs (Ibuprofen, Naproxen)
moderatemay reduce Qbrelis effectiveness and increase kidney damage risk
Lithium
moderateQbrelis can increase lithium blood levels, leading to toxicity
Gold injections
moderaterisk of nitritoid reactions (flushing, nausea, low blood pressure)
Qbrelis fills an important niche as the only FDA-approved Lisinopril oral solution, making ACE inhibitor therapy accessible to children, elderly patients, and anyone who has difficulty swallowing tablets. However, its specialty status, single manufacturer (Azurity Pharmaceuticals), and high retail price ($690–$800) make it challenging to find and afford. If you have commercial insurance, the Azurity copay assistance card may bring your cost to as little as $0. For patients who can take tablets, generic Lisinopril at $4–$15 is a far more affordable and widely available option. If you're struggling to find Qbrelis in stock, Medfinder can help you locate pharmacies that have it available near you.
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