Dexmethylphenidate XR is a once-daily, extended-release stimulant medication used to treat Attention Deficit Hyperactivity Disorder (ADHD) in patients aged 6 and older.

What Is Dexmethylphenidate XR?

Dexmethylphenidate XR is the extended-release form of Dexmethylphenidate Hydrochloride, sold under the brand name Focalin XR. It was originally manufactured by Novartis Pharmaceuticals and is now available in both brand and generic versions.

Dexmethylphenidate is the purified, pharmacologically active form (the d-threo enantiomer) of Methylphenidate — the same active ingredient in Ritalin and Concerta. Because it uses only the active half of the molecule, it works at roughly half the dose of regular Methylphenidate.

It belongs to the drug class known as CNS (central nervous system) stimulants and is classified as a Schedule II controlled substance by the DEA, meaning it has medical uses but also a high potential for abuse and dependence.

What Is Dexmethylphenidate XR Used For?

FDA-Approved Use

Dexmethylphenidate XR is FDA-approved for the treatment of ADHD in patients aged 6 years and older, including children, adolescents, and adults. ADHD is characterized by persistent patterns of inattention, hyperactivity, and impulsivity that interfere with daily functioning.

Off-Label Uses

Some doctors may prescribe Dexmethylphenidate off-label for:

• Treatment-resistant depression (as an augmentation therapy)
• Fatigue in cancer patients
• Cognitive enhancement during brain injury recovery

Off-label use means the medication is prescribed for a purpose not specifically approved by the FDA, which is a common and legal practice in medicine.

How Is Dexmethylphenidate XR Taken?

Dexmethylphenidate XR comes as extended-release capsules in the following strengths: 5 mg, 10 mg, 15 mg, 20 mg, 25 mg, 30 mg, 35 mg, and 40 mg.

Dosing

• Adults: Starting dose is typically 10 mg once daily in the morning, increased by 10 mg per week as needed. Maximum dose is 40 mg/day.
• Children (age 6+): Starting dose is typically 5 mg once daily in the morning, increased by 5 mg per week as needed. Maximum dose is 30 mg/day.

How to Take It

• Take once daily in the morning, with or without food.
• Swallow the capsule whole.
• If you can't swallow capsules: Open the capsule and sprinkle the beads on a spoonful of applesauce. Swallow immediately without chewing. Do not save the mixture for later.
• Do not crush, chew, or divide the beads — this can release the entire dose at once and increase the risk of side effects.

For more details on how this medication works in your body, see our guide on how Dexmethylphenidate XR works.

Who Should Not Take Dexmethylphenidate XR?

Dexmethylphenidate XR is not safe for everyone. You should not take this medication if you have:

• Known allergy to Methylphenidate or Dexmethylphenidate
• Glaucoma
• Motor tics or a family history or diagnosis of Tourette's syndrome
• Pre-existing structural cardiac abnormalities or serious heart problems
• Marked anxiety, tension, or agitation (the medication can make these worse)
• Current use of an MAO inhibitor or use within the last 14 days

Your doctor should also use caution if you have:

• High blood pressure or other cardiovascular conditions
• A history of seizures
• Bipolar disorder or psychosis
• A history of substance abuse

For women who are pregnant or breastfeeding, Dexmethylphenidate XR is Pregnancy Category C and should only be used if the benefits clearly outweigh the risks. It is not recommended during breastfeeding.

What Are the Side Effects?

Common side effects include decreased appetite, headache, insomnia, stomach pain, nausea, anxiety, and dry mouth. Serious but rare side effects include cardiovascular events, psychiatric symptoms, and growth suppression in children.

For the full breakdown, read our detailed guide on Dexmethylphenidate XR side effects.

What About Drug Interactions?

Dexmethylphenidate XR can interact with several medications, including MAO inhibitors (contraindicated), blood pressure medications, anticoagulants like Warfarin, and antidepressants. For the complete list, see our guide on Dexmethylphenidate XR drug interactions.

How Much Does Dexmethylphenidate XR Cost?

Cost depends on whether you're getting the brand name or generic version:

• Brand-name Focalin XR: $250 to $490 per month (30 capsules) at cash price
• Generic Dexmethylphenidate ER: $40 to $150 per month (30 capsules) with a coupon from GoodRx or similar services

Insurance Coverage

Generic Dexmethylphenidate ER is generally covered on most insurance plans, often as a Tier 2 medication. Brand-name Focalin XR may require prior authorization or step therapy (trying generic first).

Ways to Save

• Novartis Savings Card: For commercially insured patients — pay as little as $10 per fill, with Novartis covering up to $60. Not valid for Medicare, Medicaid, or Tricare.
• Coupon cards: GoodRx, SingleCare, and other discount tools can significantly reduce the cost of generic Dexmethylphenidate ER.
• Patient assistance programs: The Novartis Patient Assistance Foundation provides free Focalin XR to eligible uninsured or underinsured patients.

For the complete savings guide, see how to save money on Dexmethylphenidate XR.

Availability in 2026

Dexmethylphenidate XR has been affected by the ongoing ADHD medication shortage that began in late 2022. Multiple strengths from various manufacturers are on back order as of early 2026.

If you're having trouble finding it, use Medfinder to check which pharmacies near you have it in stock. You can also read our guide on how to find Dexmethylphenidate XR in stock near you.

Final Thoughts

Dexmethylphenidate XR is a well-established, effective ADHD medication that provides all-day symptom control with a single morning dose. It's the purified active form of Methylphenidate, available in both brand (Focalin XR) and generic versions. While it's a powerful tool for managing ADHD, it's a Schedule II controlled substance that requires careful monitoring by your healthcare provider.

If you think Dexmethylphenidate XR might be right for you, start by talking to your doctor. And if you already have a prescription, Medfinder can help you find it in stock near you.