What Is Amphetamine/Dextroamphetamine? Uses, Dosage, and What You Need to Know in 2026

Amphetamine/Dextroamphetamine is a prescription central nervous system (CNS) stimulant used to treat attention-deficit/hyperactivity disorder (ADHD) and narcolepsy in adults and children.

If you've heard of Adderall, you already know this medication — Amphetamine/Dextroamphetamine is the generic name for the same drug. It's one of the most widely prescribed ADHD medications in the United States, and it's been the subject of a prolonged national shortage that has affected millions of patients. Here's everything you need to know about it in 2026.

What Is Amphetamine/Dextroamphetamine?

Amphetamine/Dextroamphetamine is a combination of four amphetamine salts (75% dextroamphetamine and 25% levoamphetamine). It belongs to the amphetamine class of CNS stimulants. Here are the key facts:

• Brand names: Adderall (immediate-release), Adderall XR (extended-release), Mydayis (triple-bead extended-release)
• Drug class: CNS stimulant, amphetamine
• Manufacturers: Teva Pharmaceuticals (brand), plus multiple generic manufacturers including Sandoz, Mallinckrodt, Lannett, Sun Pharma, and Amneal
• FDA approval: Approved for ADHD and narcolepsy
• DEA schedule: Schedule II controlled substance — meaning it has accepted medical uses but carries a high potential for abuse and dependence

For a detailed explanation of how the medication works in your brain, see our guide: How Does Amphetamine/Dextroamphetamine Work?

What Is Amphetamine/Dextroamphetamine Used For?

ADHD (Attention-Deficit/Hyperactivity Disorder)

This is the primary use. Amphetamine/Dextroamphetamine is FDA-approved for ADHD in adults and children aged 3 and older. It helps improve focus, attention, and impulse control by increasing dopamine and norepinephrine activity in the brain.

Narcolepsy

The immediate-release formulation is also approved for narcolepsy, a sleep disorder that causes excessive daytime sleepiness and sudden sleep attacks.

Off-Label Uses

Some doctors may prescribe Amphetamine/Dextroamphetamine off-label for treatment-resistant depression (as an augmentation strategy), binge eating disorder, or excessive daytime sleepiness from other causes. These uses are not FDA-approved.

How Is Amphetamine/Dextroamphetamine Taken?

The medication comes in three main forms:

Immediate-Release (IR) Tablets

Available in 5mg, 7.5mg, 10mg, 12.5mg, 15mg, 20mg, and 30mg strengths. Taken 2-3 times per day, with doses spaced 4-6 hours apart. The first dose is taken in the morning upon waking. Typical daily dose range: 5-40mg.

Extended-Release (XR) Capsules

Available in 5mg, 10mg, 15mg, 20mg, 25mg, and 30mg strengths. Taken once daily in the morning. Capsules can be swallowed whole or opened and sprinkled on applesauce (do not chew the beads). Typical daily dose range: 10-30mg.

Mydayis (Triple-Bead Extended-Release)

Available in 12.5mg, 25mg, 37.5mg, and 50mg strengths. Designed for up to 16 hours of coverage. Taken once daily in the morning.

General tips:

• Take the first dose as early as possible to avoid insomnia
• Can be taken with or without food, but high-fat meals may delay absorption of XR formulations
• Avoid taking the immediate-release version after 2-3 PM
• Citrus juices and Vitamin C can decrease absorption — avoid them around dosing time

Who Should Not Take Amphetamine/Dextroamphetamine?

This medication is not safe for everyone. Do not take it if you have:

• A known allergy to amphetamines
• Taken an MAO inhibitor within the past 14 days (risk of hypertensive crisis)
• Glaucoma
• Moderate to severe high blood pressure
• Advanced arteriosclerosis (hardening of the arteries)
• Hyperthyroidism (overactive thyroid)
• Structural heart problems or serious heart conditions
• A history of drug abuse
• An agitated state

Your doctor should also evaluate your cardiovascular health before prescribing this medication. The FDA boxed warning notes the risk of sudden death, heart attack, and stroke, particularly in patients with pre-existing heart conditions.

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How Much Does Amphetamine/Dextroamphetamine Cost?

Cost varies significantly depending on whether you're buying brand or generic, and whether you have insurance:

• Brand Adderall IR: $350-$815/month
• Brand Adderall XR: $300-$450/month
• Generic IR (with coupons): $15-$40/month
• Generic XR (with coupons): $35-$80/month

Most insurance plans cover generic Amphetamine/Dextroamphetamine as a preferred generic, meaning your copay will be on the lowest tier. Brand versions may require prior authorization.

If you're paying out of pocket, coupon cards from GoodRx and SingleCare can significantly reduce costs. For a complete breakdown of savings options, check out our guide to saving money on Amphetamine/Dextroamphetamine.

Final Thoughts

Amphetamine/Dextroamphetamine remains one of the most effective treatments for ADHD, backed by decades of clinical use. While the ongoing shortage has made it harder to access, supply is gradually improving in 2026. If you need help finding a pharmacy with it in stock, Medfinder can help you search in seconds.