Afirmelle 28 Day Is a Combination Oral Contraceptive Used to Prevent Pregnancy

Afirmelle 28 Day is a prescription combination birth control pill that contains two synthetic hormones — Levonorgestrel (a progestin) and Ethinyl Estradiol (an estrogen) — taken daily to prevent pregnancy.

Whether you've just been prescribed Afirmelle 28 Day or you're researching it before talking to your doctor, this guide covers everything you need to know: what it is, how to take it, who it's for, and how much it costs.

What Is Afirmelle 28 Day?

Afirmelle 28 Day is a generic combination oral contraceptive manufactured by Lupin Pharmaceuticals. It belongs to the same family of birth control pills as brand-name Alesse.

Here are the key facts:

• Generic name: Levonorgestrel 0.1 mg / Ethinyl Estradiol 0.02 mg
• Drug class: Combination oral contraceptive (estrogen/progestin)
• Manufacturer: Lupin Pharmaceuticals
• Controlled substance: No — Afirmelle 28 Day is not a controlled substance
• Available as generic: Yes — Afirmelle itself is a generic product

Each 28-day pack contains 21 active tablets (containing the hormones) and 7 inert (reminder) tablets (no active ingredients). The inert tablets help you maintain the daily habit of taking a pill while you have your withdrawal period.

Other brands that contain the same active ingredients include Aviane, Aubra, Vienva, Lutera, Falmina, Sronyx, Orsythia, and many others. For a full list, see our guide to Afirmelle 28 Day alternatives.

What Is Afirmelle 28 Day Used For?

Afirmelle 28 Day is FDA-approved for the prevention of pregnancy (oral contraception). That's its primary indicated use.

However, doctors also commonly prescribe it off-label for other conditions:

• Regulating menstrual cycles — Helps create a predictable, lighter period
• Treating dysmenorrhea (painful periods) — Reduces cramping and menstrual pain
• Managing acne — The hormonal balance can improve skin over time
• Reducing menstrual-related anemia — Lighter periods mean less blood loss
• Treating endometriosis symptoms — Can help manage pain associated with endometriosis
• Managing PCOS symptoms — Helps regulate cycles and reduce androgen-related symptoms in polycystic ovary syndrome

How Is Afirmelle 28 Day Taken?

Afirmelle 28 Day is taken as one tablet by mouth every day, at the same time each day. Here's how it works:

1. Start on the right day: Begin with the first active (white) tablet on the first day of your period or the first Sunday after your period begins (your doctor will tell you which start method to use).
2. Take one active tablet daily for 21 days: These contain the hormones that prevent pregnancy.
3. Take one inert tablet daily for 7 days: These are the green reminder tablets. You'll likely have your period during this week.
4. Start a new pack immediately: Begin a new 28-day pack the day after finishing the last inert tablet. Don't skip any days between packs.

Important tips:

• Take it at the same time every day — consistency matters for effectiveness
• If you start mid-cycle, use a backup method (like condoms) for the first 7 days
• If you miss a pill, take it as soon as you remember. If you miss two or more, check your pill pack instructions or call your doctor
• Vomiting or diarrhea within a few hours of taking the pill can reduce effectiveness — use a backup method if this happens

For details about how the pill works in your body, read our guide on how Afirmelle 28 Day works.

Who Should Not Take Afirmelle 28 Day?

Afirmelle 28 Day is not safe for everyone. You should not take it if you:

• Are pregnant or think you might be pregnant
• Smoke and are over 35 years old
• Have a history of blood clots (deep vein thrombosis or pulmonary embolism)
• Have had a stroke or heart attack
• Have coronary artery disease
• Have uncontrolled high blood pressure
• Have diabetes with vascular complications
• Have breast cancer or other estrogen/progestin-sensitive cancers
• Have liver disease or liver tumors
• Have undiagnosed abnormal uterine bleeding
• Get severe migraines with aura
• Have hereditary or acquired blood clotting disorders (thrombophilias)
• Are taking certain Hepatitis C medications (Ombitasvir/Paritaprevir/Ritonavir)

If you're breastfeeding, talk to your doctor before taking Afirmelle 28 Day, as it may reduce milk production. Your doctor should also know if you have diabetes, high cholesterol, obesity, or a family history of blood clotting problems.

For more on side effects and warning signs, see our side effects guide.

How Much Does Afirmelle 28 Day Cost?

Here's what you can expect to pay for Afirmelle 28 Day in 2026:

• With insurance: Most insurance plans cover Afirmelle 28 Day with no copay under the ACA contraceptive mandate. Some plans may require generic substitution.
• Without insurance (cash price): $25 to $50 per 28-day pack
• With a discount card: As low as $9 to $15 per pack using coupons from GoodRx, SingleCare, or other discount programs

Because Afirmelle 28 Day is already a generic product, there's no manufacturer copay card available. However, patient assistance programs like the Patient Access Network Foundation (PAN) offer help for qualifying patients with insurance. You can also check NeedyMeds and RxAssist for additional assistance programs.

For a complete breakdown of savings options, read our guide to saving money on Afirmelle 28 Day.

Final Thoughts

Afirmelle 28 Day is a safe, effective, and affordable birth control option for most people. It's been on the market for years, uses well-studied active ingredients, and is widely available as a generic.

If you've been prescribed Afirmelle 28 Day and need help finding it at a pharmacy, Medfinder can help you locate it in stock near you. And if you have questions about interactions with other medications, check our drug interactions guide.

Talk to your doctor or pharmacist if you have any questions about whether Afirmelle 28 Day is right for you.