Theophylline Shortage in 2026: What's Going On?

If you take Theophylline for asthma or COPD, you've probably felt the impact of ongoing supply disruptions. The Theophylline shortage has been a frustrating reality for patients since it first appeared on the FDA's Drug Shortage list around 2022 — and heading into 2026, the situation remains uneven.

Here's what you need to know right now: where things stand, why the shortage continues, what it's costing patients, and how to find Theophylline in stock.

Is Theophylline Still in Shortage?

As of early 2026, Theophylline extended-release tablets remain intermittently available. Some strengths and formulations are easier to find than others. Here's the general picture:

• 100 mg and 200 mg ER tablets: Generally more available, though spot shortages still occur
• 300 mg and 400 mg ER tablets: More frequently affected by supply gaps
• Oral solution (Elixophyllin): Has been particularly hard to find since 2023
• Extended-release capsules (Theo-24): Limited availability — mostly replaced by generic ER tablets

The FDA continues to monitor the situation and work with manufacturers to restore supply. But "intermittent shortage" means your experience depends on where you live and which pharmacy you use.

Why Is Theophylline Still Hard to Find?

The shortage comes down to a combination of factors we've covered in our deep dive on why Theophylline is so hard to find. In short:

• Limited manufacturers: Only a handful of companies still produce generic Theophylline, and when one has a production issue, supply drops significantly.
• Raw material constraints: The active ingredient supply chain has faced disruptions.
• Low profit margins: Theophylline is cheap — which is great for patients but discourages new manufacturers from entering the market.
• Regulatory hurdles: Bringing a new generic to market or restarting production at a facility takes time, even with FDA encouragement.

What Does Theophylline Cost in 2026?

The good news: Theophylline remains one of the more affordable respiratory medications when you can find it.

• Generic ER tablets (cash price): $10-$40 per month for most strengths
• With a discount card: As low as $4-$15 per month at some pharmacies
• With insurance: Typically covered as a Tier 1 generic with a $0-$10 copay

However, during active shortages, some pharmacies charge a premium or may only have more expensive formulations available. If cost is a concern, read our guide on how to save money on Theophylline.

Are There New Options for Theophylline Patients?

While no new Theophylline formulations have launched recently, there are a few developments worth knowing about:

• Additional generic manufacturers: The FDA has been encouraging more companies to produce Theophylline. Any new entrants to the market would help stabilize supply.
• Alternative medications: If you've been unable to find Theophylline consistently, your doctor may suggest switching to a different medication class. Options include Tiotropium (Spiriva), Montelukast (Singulair), or long-acting beta-agonist inhalers. See our full list of Theophylline alternatives.
• Compounding pharmacies: Some compounding pharmacies can prepare Theophylline capsules in custom doses if standard formulations are unavailable. Ask your doctor if this is appropriate for you.

How to Find Theophylline in Stock Right Now

Here's your action plan:

1. Check Medfinder: Visit Medfinder.com and search for Theophylline to see real-time pharmacy availability in your area.
2. Call independent pharmacies: They often have access to different suppliers than chain pharmacies.
3. Ask your pharmacist to order it: If your pharmacy can get it from their distributor within a few days, a special order may be the simplest solution.
4. Try mail-order: Your insurance plan's mail-order pharmacy may have more consistent stock for a 90-day supply.
5. Don't wait until you're out: Refill 7-10 days early to give yourself time to search if needed.

For more strategies, see our detailed guide: How to find Theophylline in stock near you.

Final Thoughts

The Theophylline shortage in 2026 isn't a crisis — but it is an ongoing inconvenience that requires patients to be proactive. The drug is still being manufactured, and supply is slowly improving. But until production fully catches up with demand, you may need to put in some extra effort to keep your prescription filled.

Stay ahead of your refills, use tools like Medfinder, and keep your doctor in the loop. If Theophylline becomes consistently unavailable in your area, don't hesitate to discuss alternative treatment options with your healthcare team.