What You Should Know About Proctofoam-Hc Side Effects

If your doctor has prescribed Proctofoam-Hc for hemorrhoids, anal fissures, or another anorectal condition, you probably want to know what side effects to expect. The good news: most people tolerate Proctofoam-Hc well, and serious side effects are rare — especially with short-term use. But it's still important to know what to watch for.

This guide covers the common and serious side effects of Proctofoam-Hc, who's at higher risk, and when you should contact your doctor.

What Is Proctofoam-Hc?

Proctofoam-Hc is a prescription rectal foam containing two active ingredients: Hydrocortisone Acetate 1% (a corticosteroid that reduces inflammation) and Pramoxine Hydrochloride 1% (a local anesthetic that numbs pain and itching). It's manufactured by Mylan Specialty L.P., a Viatris company.

For a deeper look at how these ingredients work together, see our article on how Proctofoam-Hc works. For full prescribing details, read What Is Proctofoam-Hc?

Common Side Effects

These side effects are relatively mild and usually go away on their own as your body adjusts to the medication. They include:

• Burning or stinging at the application site — This is the most commonly reported side effect. It typically lasts a few minutes after application and fades quickly.
• Redness at the application site — Temporary redness or warmth around the treated area.
• Skin dryness or peeling — The skin around the application site may become dry or flaky.
• Mild itching — Some people experience temporary itching, which can be frustrating since itching is often why the medication was prescribed in the first place.
• Acne — Topical corticosteroids can occasionally cause acne-like breakouts near the treated area.
• Changes in skin color — The treated area may become slightly lighter or darker. This is usually temporary.

Most of these side effects are mild and resolve within a few days of starting treatment. If they persist or worsen, let your doctor know.

Serious Side Effects

Serious side effects from Proctofoam-Hc are uncommon, especially when the medication is used as directed for short periods. However, you should be aware of the following:

Allergic Reaction

Though rare, some people may have an allergic reaction to Hydrocortisone, Pramoxine, or another ingredient in the formulation. Seek immediate medical attention if you experience:

• Hives or widespread rash
• Difficulty breathing or swallowing
• Swelling of the face, lips, tongue, or throat

Skin Thinning (Atrophy)

Prolonged use of topical corticosteroids like Hydrocortisone can cause the skin to become thin and fragile. Signs include:

• Skin that bruises easily
• Visible blood vessels under the skin
• Stretch marks (striae)

This is why doctors typically recommend using Proctofoam-Hc for limited periods — usually no longer than 2 to 3 weeks unless directed otherwise.

Secondary Skin Infections

Corticosteroids suppress the local immune response, which can make the treated area more susceptible to bacterial, fungal, or viral infections. If you notice increased redness, pus, warmth, or worsening symptoms, contact your doctor.

Systemic Corticosteroid Effects

With excessive or prolonged use, Hydrocortisone can be absorbed into your bloodstream and cause systemic effects. These are rare with topical rectal use but may include:

• Mood changes or irritability
• Insomnia
• Weight gain
• Increased thirst and urination
• Muscle weakness
• Blurred vision or eye pain

HPA Axis Suppression

In extreme cases of prolonged use, topical corticosteroids can suppress your body's natural cortisol production (known as HPA axis suppression). This is very unlikely with standard Proctofoam-Hc use but is a reason not to use the medication longer than prescribed.

Side Effects in Specific Populations

Pregnant Women

Proctofoam-Hc should be used during pregnancy only when clearly needed. Prolonged use or application over large areas should be avoided. If you're pregnant or planning to become pregnant, discuss the risks and benefits with your doctor.

Breastfeeding Women

It's not known whether the ingredients in Proctofoam-Hc are excreted in breast milk. Talk to your doctor before using this medication while breastfeeding.

Children

Children may be more susceptible to systemic effects from topical corticosteroids because they have a higher body-surface-area-to-weight ratio. Proctofoam-Hc should be used with caution in pediatric patients and only under close medical supervision.

Older Adults

Elderly patients may have thinner skin, which could increase the risk of skin atrophy and bruising. Lower frequency of application or shorter treatment duration may be appropriate.

How to Manage Common Side Effects

If you experience mild side effects from Proctofoam-Hc, here are some practical tips:

• Burning or stinging: This usually resolves within minutes. If it's bothersome, try applying a thin layer of plain petroleum jelly to the perianal area before using the foam.
• Dryness or peeling: Keep the area clean and dry. Avoid using harsh soaps or wipes. Fragrance-free, alcohol-free wipes are gentler on sensitive skin.
• Itching: Resist the urge to scratch, which can worsen irritation. Cool compresses or sitz baths can provide temporary relief between applications.
• Skin color changes: These typically resolve after you stop using the medication. No specific treatment is needed.

If side effects don't improve within a few days, or if they're affecting your quality of life, contact your doctor. They may adjust your treatment plan or suggest an alternative medication.

When to Call Your Doctor

Contact your doctor promptly if you experience any of the following while using Proctofoam-Hc:

• Signs of an allergic reaction (hives, difficulty breathing, facial swelling)
• Worsening symptoms or no improvement after 2 to 3 weeks of use
• Signs of skin infection (increased pain, pus, warmth, spreading redness)
• Blurred vision or eye pain
• Unusual mood changes, weight gain, or muscle weakness
• Stretch marks or noticeably thinner skin in the treated area

If you experience severe difficulty breathing or swelling of the throat, call 911 or go to your nearest emergency room immediately.

Final Thoughts

Proctofoam-Hc is generally well-tolerated, and most side effects are mild and temporary. The key to minimizing risks is using the medication exactly as prescribed — at the recommended dose, for the recommended duration.

If you have concerns about side effects, talk to your doctor before starting treatment. And if you need help finding Proctofoam-Hc at a pharmacy near you, use Medfinder to check availability.

For more information about this medication, see our complete guides on what Proctofoam-Hc is, drug interactions to watch for, and how to save money on your prescription.