Comprehensive medication guide to Analpram HC including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0–$30 copay for generic hydrocortisone-pramoxine on most commercial insurance plans (Tier 1–2); brand-name Analpram HC may require prior authorization or be placed on a higher tier depending on your plan.
Estimated Cash Pricing
$157–$390 retail for brand-name Analpram HC; generic hydrocortisone-pramoxine topical available for as low as $40–$41 with a GoodRx coupon or ~$130 with SingleCare for a 30g tube.
Medfinder Findability Score
80/100
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Analpram HC is a brand-name prescription topical medication manufactured by Sebela Pharmaceuticals (distributed by Legacy Pharma). It combines two active ingredients: hydrocortisone acetate (a low-potency corticosteroid) and pramoxine hydrochloride (a topical local anesthetic). The most common strength is 2.5%/1% cream, though 1%/1% formulations are also available in cream, lotion, and foam.
Analpram HC is primarily used to treat hemorrhoids, anal fissures, anorectal irritation, and other corticosteroid-responsive dermatoses including eczema, psoriasis, and contact dermatitis. It is not a controlled substance and is available in generic form as hydrocortisone-pramoxine topical.
Other brand names containing the same hydrocortisone/pramoxine combination include Pramosone, Epifoam, Proctofoam HC, ProCort, Analpram E, and PramCort. The generic (hydrocortisone-pramoxine topical) is widely available at most pharmacies.
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Analpram HC works through two distinct mechanisms. Hydrocortisone acetate is a corticosteroid that binds to glucocorticoid receptors in skin cells, suppressing the migration of inflammatory cells (PMNs), reversing increased capillary permeability, and inhibiting the release of inflammatory mediators (prostaglandins, histamine). This reduces swelling, redness, and itching. Hydrocortisone also has vasoconstrictive properties that help shrink engorged hemorrhoidal tissue.
Pramoxine hydrochloride is a topical local anesthetic with a unique morpholine structure. It stabilizes the neuronal membranes of sensory nerve endings by blocking sodium channels, preventing the transmission of pain and itch signals to the brain. Relief typically begins in 2–5 minutes after application.
Together, these two mechanisms provide rapid symptomatic relief (pramoxine) while addressing underlying inflammation (hydrocortisone). This dual-action approach is the key clinical advantage of combination products like Analpram HC over single-ingredient treatments.
2.5%/1% — cream
Brand Analpram HC 2.5%/1% cream; most common prescription strength; 1 oz tube with multi-port applicator
1%/1% — cream
Lower strength cream formulation; available in brand and generic
2.5%/1% — lotion
Lotion formulation; 2 fl oz bottle; Analpram HC Lotion
1%/1% — foam
Foam formulation (Epifoam/Proctofoam HC); pressurized canister for rectal use
Analpram HC is not on the FDA's official Drug Shortages Database as of 2026 — there is no national shortage. However, patients do occasionally experience localized stockouts at specific pharmacies due to low stocking priority for specialty topical combination products and variability in brand vs. generic ordering by different pharmacy chains.
The generic equivalent (hydrocortisone-pramoxine topical) is produced by multiple manufacturers and is generally more reliably and widely stocked than the brand-name product. Patients who can accept the generic typically have little difficulty filling their prescription.
If you're having trouble finding Analpram HC at your pharmacy, medfinder can help. Provide your medication details and location, and medfinder's team will call pharmacies near you to find which ones can fill your prescription, then text you the results.
Analpram HC is not a controlled substance and does not require any special DEA prescribing authority. Any licensed prescriber with standard prescriptive authority can write for this medication.
Primary Care Physicians (PCPs) and Family Medicine Doctors
Gastroenterologists
Colorectal Surgeons
Dermatologists
Nurse Practitioners (NPs) and Physician Assistants (PAs)
OB/GYN physicians and Certified Nurse-Midwives (CNMs)
Analpram HC can also be prescribed through telehealth services without federal restrictions, since it is not a controlled substance. Many telehealth platforms (including Teladoc, MDLive, and Sesame) can evaluate anorectal and skin conditions and send a prescription directly to your pharmacy.
No. Analpram HC is not a controlled substance. Neither hydrocortisone acetate nor pramoxine hydrochloride is scheduled under the DEA Controlled Substances Act. Analpram HC does not require any special DEA number to prescribe, and prescriptions can be written by any licensed prescriber with standard prescriptive authority.
Because it is not a controlled substance, Analpram HC can be prescribed via telemedicine without federal restrictions, transferred between pharmacies, and refilled according to the prescriber's instructions without the special limitations that apply to Schedule II–V medications.
Most patients tolerate Analpram HC well when used as directed. Common local reactions include:
Burning or stinging at the application site (usually brief)
Mild itching or irritation
Skin dryness or redness
Folliculitis (small red bumps around hair follicles)
Serious side effects are rare with proper use but can include:
HPA axis (adrenal) suppression — rare with low-potency hydrocortisone; risk increases with large-area or prolonged use
Skin atrophy or thinning — with long-term or high-dose use
Cushing's syndrome — very rare with topical low-potency corticosteroids
Allergic reactions — including contact dermatitis or systemic hypersensitivity
Secondary infections — topical steroids can mask signs of infection; avoid use on infected skin
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Pramosone / Pramosone E
Brand-name equivalent containing the same hydrocortisone/pramoxine combination; available as cream, lotion, and ointment
Proctofoam HC / Epifoam
Foam formulation of hydrocortisone 1%/pramoxine 1%; pressurized canister preferred by some patients for rectal application
Ana-Lex / Lidamantle HC
Hydrocortisone + lidocaine combination; appropriate alternative when pramoxine is unavailable or patient has pramoxine sensitivity
OTC Hydrocortisone 1% (Preparation H, Cortizone-10)
Available without prescription for mild symptoms; lacks pramoxine anesthetic component
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Desmopressin (DDAVP)
moderateHydrocortisone may reduce the antidiuretic effects of desmopressin. Inform your doctor if you take desmopressin for bleeding disorders, bedwetting, or diabetes insipidus.
Other topical corticosteroids
moderateCombining multiple topical steroid products increases total steroid absorption and risk of HPA axis suppression and skin thinning.
Oral/systemic corticosteroids (prednisone, dexamethasone)
moderateAdditive corticosteroid effects when combined with systemic steroids; monitor for signs of adrenal suppression with extended use.
Diabetes medications (insulin, metformin)
moderateHydrocortisone can raise blood glucose, potentially requiring adjustment of diabetes medications especially with large-area or prolonged use.
Immunosuppressants (tacrolimus, cyclosporine)
moderateAdditive immunosuppressive effects; increased risk of infections when combined.
Analpram HC is an effective, well-established prescription combination cream for hemorrhoids, anorectal irritation, and skin conditions. Its dual-action formula — combining the anti-inflammatory power of hydrocortisone with the rapid numbing effect of pramoxine — makes it a preferred choice for patients who need both inflammation control and immediate pain relief.
While brand-name Analpram HC can be expensive ($150–$390 retail), the generic equivalent is widely available for $40–$41 with a GoodRx coupon. For most patients, the generic is the most practical and cost-effective option. If you're prescribed brand-name Analpram HC, ask your doctor or pharmacist whether the generic is appropriate for your situation.
If you need help finding Analpram HC or its generic at a pharmacy near you, medfinder can help. Our team calls pharmacies in your area to find which ones have your prescription in stock and texts you the results — saving you time and the frustration of calling around yourself.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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