Is Orilissa Actually in Shortage?

If you've been struggling to find Orilissa (Elagolix) at your pharmacy, you're probably wondering: is this drug actually in a shortage? The short answer is no — Orilissa is not currently listed on the FDA or ASHP drug shortage databases as of early 2026. But that doesn't mean it's easy to find.

The reality is more nuanced. Orilissa is a specialty brand-name medication made by a single company (AbbVie). Many retail pharmacies don't stock it because of low demand and high cost. So while the supply chain isn't officially disrupted, many patients experience what feels like a shortage every time they try to fill their prescription.

In this article, we'll break down what's really going on with Orilissa availability in 2026 and what you can do about it.

Is Orilissa Still Hard to Find in 2026?

Yes. Even without an official shortage, Orilissa remains difficult to locate at many pharmacies. Here's why:

• Single manufacturer: AbbVie is the only company that makes Orilissa. There is no generic version of Elagolix available.
• Low stocking rates: Many retail pharmacies (CVS, Walgreens, Rite Aid) don't routinely carry Orilissa because relatively few patients in any given area need it.
• Specialty pharmacy requirements: Some insurance plans require Orilissa to be filled at a designated specialty pharmacy, which may not be near you.
• Prior authorization delays: Insurance often requires prior authorization before Orilissa can be dispensed, adding days or weeks to the process.

Why Is Orilissa Hard to Find? A Quick Recap

We covered this in depth in our article on why Orilissa is so hard to find, but here's a summary:

1. Niche indication: It's only approved for endometriosis pain in premenopausal women.
2. No generic: A single-source brand-name drug is inherently less available than one with multiple generic manufacturers.
3. High cost: At $1,200–$1,700 per month, pharmacies are cautious about stocking it.
4. Insurance barriers: Prior authorization and step therapy requirements slow down the dispensing process.

How Much Does Orilissa Cost in 2026?

The cash price for a 28-day supply of Orilissa remains high:

• Orilissa 150 mg (28 tablets): Approximately $1,200–$1,700
• Orilissa 200 mg (56 tablets for twice-daily dosing): Approximately $2,400–$3,400

With insurance and the AbbVie savings card, eligible patients may pay as little as $5 per month. Without insurance, patient assistance programs through AbbVie (myAbbVie Assist) may cover the full cost for qualifying patients.

For a complete breakdown, read our guide on how to save money on Orilissa.

Are There New Options in 2026?

While Orilissa itself hasn't changed, the treatment landscape for endometriosis has expanded:

• Myfembree (Relugolix/Estradiol/Norethindrone acetate): An oral GnRH antagonist combination with built-in add-back therapy. May be easier to access for some patients.
• Lupron Depot (Leuprolide): Still widely used as a GnRH agonist injection for endometriosis.
• Norethindrone acetate: An affordable oral progestin (under $30/month) used off-label for endometriosis pain.

Talk to your doctor about whether any of these might be appropriate. For more details, see our article on alternatives to Orilissa.

How to Find Orilissa in Stock Right Now

If you need Orilissa and can't find it, here's what to do:

1. Search on Medfinder: Check real-time pharmacy inventory near your zip code.
2. Contact specialty pharmacies: They're more likely to stock Orilissa than retail chains.
3. Ask your pharmacy to order it: Most pharmacies can get it from their wholesaler in 1–3 business days.
4. Call AbbVie: The manufacturer (1-800-222-6885) can help locate pharmacies that carry Orilissa.

For a detailed walkthrough, read how to find Orilissa in stock near you.

Final Thoughts

Orilissa isn't in a formal shortage, but it's also not sitting on every pharmacy shelf. The combination of being a high-cost, single-manufacturer specialty drug means that finding it requires a more proactive approach than most medications. Use the tools and tips above to stay ahead of availability issues, and keep the lines of communication open with your doctor and pharmacist.

For more information about what Orilissa is and how it works, check out our detailed guide: What is Orilissa? Uses, dosage, and what you need to know.