Orilissa Is Effective — But It's Also Expensive

If you've been prescribed Orilissa (Elagolix) for endometriosis pain, you already know it works. What you may not know is how much it costs — and that can be a shock. Without insurance, a single month's supply of Orilissa can cost $1,200 to $1,700 or more.

The good news? There are real ways to reduce what you pay. In this guide, we'll walk through the actual cost of Orilissa, the best savings programs available in 2026, and other strategies to bring your out-of-pocket cost down — in some cases, to as little as $5 per month.

How Much Does Orilissa Cost Without Insurance?

Here's what you can expect to pay at the pharmacy counter without insurance coverage:

• Orilissa 150 mg (28 tablets, once-daily dosing): Approximately $1,200–$1,700
• Orilissa 200 mg (56 tablets, twice-daily dosing): Approximately $2,400–$3,400

These prices vary by pharmacy. According to SingleCare, the average cash price for a 28-day supply of Orilissa 150 mg is approximately $1,697, with savings card prices starting around $1,194.

There is no generic version of Elagolix available as of 2026, which keeps prices high. Orilissa is made exclusively by AbbVie.

Option 1: AbbVie Orilissa Savings Card (Best for Commercially Insured Patients)

AbbVie offers an Orilissa Savings Card that can dramatically reduce your out-of-pocket cost if you have commercial (private) insurance.

Key details:

• Eligible patients may pay as little as $5 per month
• Available to patients with commercial insurance coverage for Orilissa
• Not valid for patients with government insurance (Medicare, Medicaid, Tricare, VA)
• Enroll online at orilissa.com or call 1-800-222-6885

This is typically the single best way to save on Orilissa if you have private insurance. The savings card covers the difference between your copay and $5, up to the program's maximum annual benefit.

Option 2: myAbbVie Assist (Best for Uninsured or Underinsured Patients)

If you don't have insurance or your insurance doesn't cover Orilissa, AbbVie's patient assistance program — myAbbVie Assist — may provide the medication at no cost.

Key details:

• For patients who are uninsured or whose insurance does not cover Orilissa
• Income eligibility requirements apply (based on household size and income)
• If approved, you may receive Orilissa free of charge
• Apply online at abbvie.com/myAbbVieAssist or call 1-800-222-6885

The application process typically takes 1–2 weeks. Your doctor's office may need to provide supporting documentation. If you're struggling to afford Orilissa, this program is absolutely worth applying to.

Option 3: Prescription Discount Cards

If you don't qualify for the AbbVie savings card or patient assistance, prescription discount cards can still provide some savings — though they won't bring the price as low as AbbVie's programs.

Popular discount card options:

• SingleCare: Prices around $1,194 for a 28-day supply of Orilissa 150 mg — a savings of approximately $500 off the average cash price.
• GoodRx: May offer comparable savings depending on pharmacy location.
• RxSaver, Optum Perks, BuzzRx: Also worth checking, as prices can vary by pharmacy.

Important: Discount cards cannot be combined with insurance. They function as an alternative to your insurance price, not a supplement. Always ask the pharmacist to compare the discount card price with your insurance copay to see which is lower.

Option 4: Other Ways to Save

Beyond the main programs, here are additional strategies to reduce your Orilissa costs:

Ask About Step Therapy Alternatives

If your insurance requires step therapy before approving Orilissa (meaning you must try cheaper medications first), ask your doctor to document any prior treatment failures. A well-documented appeal can sometimes get the step therapy requirement waived.

Use a Specialty Pharmacy

Specialty pharmacies often have dedicated access coordinators who can help you navigate insurance, apply for savings programs, and find the lowest price. Some specialty pharmacies also offer their own discount programs for eligible patients.

Compare Pharmacy Prices

Orilissa prices can vary significantly between pharmacies. Use tools like Medfinder to find pharmacies that stock Orilissa, then compare pricing at each location. Even small differences can add up over months of treatment.

Ask About Samples

Some OB/GYN offices may have Orilissa samples from AbbVie sales representatives. While this isn't a long-term solution, it can bridge the gap while you're waiting for insurance approval or patient assistance program enrollment.

Consider the 150 mg Dose

If clinically appropriate, the 150 mg once-daily dose is significantly less expensive than the 200 mg twice-daily dose (roughly half the cost). Discuss with your doctor whether the lower dose might be effective for your symptoms — it can be used for up to 24 months, versus only 6 months for the higher dose.

What About Medicare Patients?

Orilissa is typically not well covered by Medicare. Medicare Part D plans may not include it on their formulary, or may place it in a high-cost specialty tier with significant cost-sharing.

Options for Medicare patients:

• Check your plan's formulary to see if Orilissa is covered and at what tier.
• Apply for myAbbVie Assist if you meet income eligibility.
• Discuss less expensive alternatives with your doctor (such as Norethindrone acetate, which is under $30/month).
• Contact your state's pharmaceutical assistance program (SPAP) for additional support.

Final Thoughts

Orilissa is expensive, but you have options. The AbbVie Savings Card can bring your copay down to $5/month with commercial insurance, and myAbbVie Assist may cover the full cost if you're uninsured. Discount cards like SingleCare and GoodRx can also help shave hundreds off the cash price.

Don't let cost keep you from getting the endometriosis treatment you need. Start by contacting AbbVie at 1-800-222-6885 to explore your options, and use Medfinder to find pharmacies near you that stock Orilissa at the best price.

For more information about finding this medication, read how to find Orilissa in stock near you. And for a full overview of the medication itself, see What is Orilissa? Uses, dosage, and what you need to know.