How to Save Money on Entresto (Sacubitril/Valsartan) in 2026: Coupons, Discounts, and Patient Assistance

Entresto is one of the most expensive heart failure medications on the market — brand-name Entresto can cost $600–$700 per month without insurance. The good news is that in 2026, there are more ways than ever to reduce that cost, from manufacturer savings cards to FDA-approved generics to Medicare price negotiations. Here is a complete guide to saving money on sacubitril/valsartan.

How Much Does Entresto Cost Without Insurance?

Here is the 2025–2026 pricing landscape for sacubitril/valsartan:

Brand-name Entresto: ~$600–$700 per 30-day supply (60 tablets of 97/103 mg) without insurance

Generic sacubitril/valsartan: ~$45–$255 per 30-day supply without insurance, depending on pharmacy and discount card

With GoodRx or SingleCare: Generic can be as low as $45–$52 per 30-day supply at CVS

Medicare Part D (IRA negotiated price): ~$295 per 30-day supply starting in 2026, with the $2,000 annual OOP cap

Option 1: Switch to Generic Sacubitril/Valsartan

The single most impactful way to lower your Entresto cost is to switch to the generic. FDA-approved generic sacubitril/valsartan — approved in May 2024 and now available from multiple manufacturers — is bioequivalent to brand-name Entresto. The same active ingredients, the same dose, the same effectiveness. Talk to your cardiologist or pharmacist about switching — it may require a new prescription or just a call to authorize generic substitution.

Option 2: Use the Novartis Entresto Copay Savings Card

If you have commercial (private) insurance, Novartis offers a copay savings card that can reduce your Entresto cost to as little as $10 per month. The program includes a Co-pay Offer, Payment Card, and Rebate with a combined annual limit of $4,100. Key conditions:

Valid only for commercially insured patients (not Medicare, Medicaid, TRICARE, VA, or other government programs)

Valid only in the United States and Puerto Rico

Cannot be combined with other coupons or third-party rebates

Patient is responsible for costs once the $4,100 annual limit is reached

Option 3: GoodRx and SingleCare Discount Cards

Free prescription savings cards from GoodRx and SingleCare can significantly reduce the cash price of generic sacubitril/valsartan when not using insurance. A 30-day supply of generic sacubitril/valsartan costs approximately $50 at CVS with a SingleCare card — versus $255+ without any discount. Compare prices across pharmacies using these apps since prices vary significantly by location.

Option 4: Medicare Patients — Know Your 2026 Benefits

Entresto was selected in the first round of Medicare Drug Price Negotiation under the Inflation Reduction Act. Starting in 2026, Medicare Part D beneficiaries pay a maximum fair price of approximately $295 per 30-day supply. Combined with the new $2,000 annual out-of-pocket cap under Part D (effective 2025), Medicare patients have significantly more protection from high Entresto costs than in previous years.

Note that Novartis's manufacturer copay card is not available to Medicare patients. However, extra help (Low Income Subsidy) programs may reduce out-of-pocket costs for qualifying Medicare beneficiaries.

Option 5: PAN Foundation Patient Assistance

The Patient Access Network (PAN) Foundation offers grants of up to $1,200 initially, with up to $2,400 per year in total, for patients with heart failure facing out-of-pocket cost barriers for Entresto. Grants are subject to funding availability — check the PAN Foundation website regularly or sign up for availability notifications since the fund opens at different times throughout the year.

Option 6: Novartis Patient Assistance Program

For patients who are uninsured or underinsured and meet income criteria, Novartis offers a Patient Assistance Program that may provide Entresto at no cost. Contact Novartis directly or visit the Entresto.com website for current eligibility requirements and to apply.

Option 7: Get a 90-Day Supply

Many insurance plans offer discounts for 90-day supplies versus 30-day fills. Mail-order pharmacies often pass on additional savings. If your dose is stable, ask your prescriber for a 90-day prescription and switch to mail order to reduce both cost and the frequency of refill-search hassles.

Finding the Cheapest Pharmacy Near You

Prices for sacubitril/valsartan vary significantly between pharmacies. Use GoodRx or SingleCare to compare prices, and use medfinder to find the pharmacies near you that have it in stock. Check out our full guide on how to find Entresto near you for more tips.